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UGT1A - 版本历史
2026-04-18T13:26:07Z
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2025年12月31日 (三) 14:55 77921020
2025-12-31T14:55:00Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2025年12月31日 (三) 14:55的版本</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l11" >第11行：</td>
<td colspan="2" class="diff-lineno">第11行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="padding: 15px; color: #1e40af; background: linear-gradient(135deg, #e0f2fe 0%, #bae6fd 100%); text-align: center; cursor: pointer;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="padding: 15px; color: #1e40af; background: linear-gradient(135deg, #e0f2fe 0%, #bae6fd 100%); text-align: center; cursor: pointer;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="font-size: 1.2em; font-weight: bold; letter-spacing: 1.2px;">UGT1A (Focus: UGT1A1)</div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="font-size: 1.2em; font-weight: bold; letter-spacing: 1.2px;">UGT1A (Focus: UGT1A1)</div></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="font-size: 0.7em; opacity: 0.85; margin-top: 4px; white-space: nowrap;">Gene Complex <del class="diffchange diffchange-inline">Profile </del>(点击展开)</div></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="font-size: 0.7em; opacity: 0.85; margin-top: 4px; white-space: nowrap;">Gene Complex <ins class="diffchange diffchange-inline">& Enzyme </ins>(点击展开)</div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
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<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l24" >第24行：</td>
<td colspan="2" class="diff-lineno">第24行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <table style="width: 100%; border-spacing: 0; border-collapse: collapse; font-size: 0.85em;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <table style="width: 100%; border-spacing: 0; border-collapse: collapse; font-size: 0.85em;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: <del class="diffchange diffchange-inline">8px </del>12px; <del class="diffchange diffchange-inline">border</del>-<del class="diffchange diffchange-inline">bottom</del>: <del class="diffchange diffchange-inline">1px solid </del>#f1f5f9; color: #475569; <del class="diffchange diffchange-inline">background</del>-<del class="diffchange diffchange-inline">color</del>: #<del class="diffchange diffchange-inline">f8fafc</del>; width: 40%;">基因座位</th></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: <ins class="diffchange diffchange-inline">6px </ins>12px; <ins class="diffchange diffchange-inline">background</ins>-<ins class="diffchange diffchange-inline">color</ins>: #f1f5f9; color: #475569; <ins class="diffchange diffchange-inline">border</ins>-<ins class="diffchange diffchange-inline">bottom</ins>: <ins class="diffchange diffchange-inline">1px solid </ins>#<ins class="diffchange diffchange-inline">e2e8f0</ins>; width: 40%;">基因座位</th></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">8px </del>12px; border-bottom: 1px solid #<del class="diffchange diffchange-inline">f1f5f9</del>; color: #0f172a;"><strong>UGT1A Complex</strong></td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">6px </ins>12px; border-bottom: 1px solid #<ins class="diffchange diffchange-inline">e2e8f0</ins>; color: #0f172a;"><strong>UGT1A Complex</strong></td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: <del class="diffchange diffchange-inline">8px </del>12px; <del class="diffchange diffchange-inline">border</del>-<del class="diffchange diffchange-inline">bottom</del>: <del class="diffchange diffchange-inline">1px solid </del>#f1f5f9; color: #475569; <del class="diffchange diffchange-inline">background</del>-<del class="diffchange diffchange-inline">color</del>: #<del class="diffchange diffchange-inline">f8fafc</del>;">核心成员</th></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: <ins class="diffchange diffchange-inline">6px </ins>12px; <ins class="diffchange diffchange-inline">background</ins>-<ins class="diffchange diffchange-inline">color</ins>: #f1f5f9; color: #475569; <ins class="diffchange diffchange-inline">border</ins>-<ins class="diffchange diffchange-inline">bottom</ins>: <ins class="diffchange diffchange-inline">1px solid </ins>#<ins class="diffchange diffchange-inline">e2e8f0</ins>;">核心成员</th></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">8px </del>12px; border-bottom: 1px solid #<del class="diffchange diffchange-inline">f1f5f9</del>; color: #0f172a;"><strong>UGT1A1</strong> (主要), UGT1A9</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">6px </ins>12px; border-bottom: 1px solid #<ins class="diffchange diffchange-inline">e2e8f0</ins>; color: #0f172a;"><strong>UGT1A1</strong> (主要), UGT1A9</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: <del class="diffchange diffchange-inline">8px </del>12px; <del class="diffchange diffchange-inline">border</del>-<del class="diffchange diffchange-inline">bottom</del>: <del class="diffchange diffchange-inline">1px solid </del>#f1f5f9; color: #475569; <del class="diffchange diffchange-inline">background</del>-<del class="diffchange diffchange-inline">color</del>: #<del class="diffchange diffchange-inline">f8fafc</del>;">染色体位置</th></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: <ins class="diffchange diffchange-inline">6px </ins>12px; <ins class="diffchange diffchange-inline">background</ins>-<ins class="diffchange diffchange-inline">color</ins>: #f1f5f9; color: #475569; <ins class="diffchange diffchange-inline">border</ins>-<ins class="diffchange diffchange-inline">bottom</ins>: <ins class="diffchange diffchange-inline">1px solid </ins>#<ins class="diffchange diffchange-inline">e2e8f0</ins>;">染色体位置</th></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">8px </del>12px; border-bottom: 1px solid #<del class="diffchange diffchange-inline">f1f5f9</del>; color: #0f172a;">2q37.1</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">6px </ins>12px; border-bottom: 1px solid #<ins class="diffchange diffchange-inline">e2e8f0</ins>; color: #0f172a;">2q37.1</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: <del class="diffchange diffchange-inline">8px </del>12px; <del class="diffchange diffchange-inline">border</del>-<del class="diffchange diffchange-inline">bottom</del>: <del class="diffchange diffchange-inline">1px solid </del>#f1f5f9; color: #475569; <del class="diffchange diffchange-inline">background</del>-<del class="diffchange diffchange-inline">color</del>: #<del class="diffchange diffchange-inline">f8fafc</del>;">Entrez ID</th></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: <ins class="diffchange diffchange-inline">6px </ins>12px; <ins class="diffchange diffchange-inline">background</ins>-<ins class="diffchange diffchange-inline">color</ins>: #f1f5f9; color: #475569; <ins class="diffchange diffchange-inline">border</ins>-<ins class="diffchange diffchange-inline">bottom</ins>: <ins class="diffchange diffchange-inline">1px solid </ins>#<ins class="diffchange diffchange-inline">e2e8f0</ins>;">Entrez ID</th></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">8px </del>12px; border-bottom: 1px solid #<del class="diffchange diffchange-inline">f1f5f9</del>; color: #1e40af;">54658 (UGT1A1)</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">6px </ins>12px; border-bottom: 1px solid #<ins class="diffchange diffchange-inline">e2e8f0</ins>; color: #1e40af;">54658 (UGT1A1)</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: <del class="diffchange diffchange-inline">8px </del>12px; <del class="diffchange diffchange-inline">border</del>-<del class="diffchange diffchange-inline">bottom</del>: <del class="diffchange diffchange-inline">1px solid </del>#f1f5f9; color: #475569; <del class="diffchange diffchange-inline">background</del>-<del class="diffchange diffchange-inline">color</del>: #<del class="diffchange diffchange-inline">f8fafc</del>;"><del class="diffchange diffchange-inline">UniProt</del></th></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: <ins class="diffchange diffchange-inline">6px </ins>12px; <ins class="diffchange diffchange-inline">background</ins>-<ins class="diffchange diffchange-inline">color</ins>: #f1f5f9; color: #475569; <ins class="diffchange diffchange-inline">border</ins>-<ins class="diffchange diffchange-inline">bottom</ins>: <ins class="diffchange diffchange-inline">1px solid </ins>#<ins class="diffchange diffchange-inline">e2e8f0</ins>;"><ins class="diffchange diffchange-inline">OMIM ID</ins></th></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">8px </del>12px; border-bottom: 1px solid #<del class="diffchange diffchange-inline">f1f5f9</del>; color: #1e40af;"><del class="diffchange diffchange-inline">P22309</del></td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">6px </ins>12px; border-bottom: 1px solid #<ins class="diffchange diffchange-inline">e2e8f0</ins>; color: #1e40af;"><ins class="diffchange diffchange-inline">191740 (Gene) / 218800 (CN-I)</ins></td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: <del class="diffchange diffchange-inline">8px </del>12px; <del class="diffchange diffchange-inline">border</del>-<del class="diffchange diffchange-inline">bottom</del>: <del class="diffchange diffchange-inline">1px solid </del>#f1f5f9; color: #475569; <del class="diffchange diffchange-inline">background</del>-<del class="diffchange diffchange-inline">color</del>: #<del class="diffchange diffchange-inline">f8fafc</del>;"><del class="diffchange diffchange-inline">反应类型</del></th></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: <ins class="diffchange diffchange-inline">6px </ins>12px; <ins class="diffchange diffchange-inline">background</ins>-<ins class="diffchange diffchange-inline">color</ins>: #f1f5f9; color: #475569; <ins class="diffchange diffchange-inline">border</ins>-<ins class="diffchange diffchange-inline">bottom</ins>: <ins class="diffchange diffchange-inline">1px solid </ins>#<ins class="diffchange diffchange-inline">e2e8f0</ins>;"><ins class="diffchange diffchange-inline">UniProt</ins></th></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">8px </del>12px; border-bottom: 1px solid #<del class="diffchange diffchange-inline">f1f5f9</del>; color: #<del class="diffchange diffchange-inline">0f172a</del>;"><del class="diffchange diffchange-inline">葡萄糖醛酸化 (Glucuronidation)</del></td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">6px </ins>12px; border-bottom: 1px solid #<ins class="diffchange diffchange-inline">e2e8f0</ins>; color: #<ins class="diffchange diffchange-inline">1e40af</ins>;"><ins class="diffchange diffchange-inline">P22309</ins></td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: <del class="diffchange diffchange-inline">8px </del>12px; color: #475569; background-color: #<del class="diffchange diffchange-inline">f8fafc</del>;">关键底物</th></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: <ins class="diffchange diffchange-inline">6px </ins>12px<ins class="diffchange diffchange-inline">; background-color: #f1f5f9</ins>; color: #475569<ins class="diffchange diffchange-inline">; border-bottom: 1px solid #e2e8f0;">蛋白长度</th></ins></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">8px </del>12px; color: #0f172a;">[[胆红素]], [[SN-38]], [[<del class="diffchange diffchange-inline">酚类]], [[雌激素</del>]]</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">533 AA (UGT1A1)</td></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <th style="text-align: left; padding: 6px 12px</ins>; background-color: #<ins class="diffchange diffchange-inline">f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">分子量</th></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">~59.6 kDa (糖基化后更大)</td></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">亚细胞定位</th></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">内质网膜 (ER Membrane)</td></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">反应类型</th></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">葡萄糖醛酸化 (II相代谢)</td></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <tr></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569</ins>;">关键底物</th></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">6px </ins>12px; color: #0f172a;">[[胆红素]], [[SN-38]], [[<ins class="diffchange diffchange-inline">雌二醇</ins>]]</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </table></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </table></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l63" >第63行：</td>
<td colspan="2" class="diff-lineno">第79行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <ul style="padding-left: 25px; color: #334155;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <ul style="padding-left: 25px; color: #334155;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 12px;"><strong>独特的基因结构 (Exon Sharing)：</strong></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 12px;"><strong>独特的基因结构 (Exon Sharing)：</strong></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <br>UGT1A 基因座全长约 200 kb。它包含多个独特的<strong>第一外显子</strong>（Exon 1），每个 Exon 1 拥有独立的启动子。这些 Exon 1 均与下游共享的 Exon 2-5 拼接。[[Image:UGT1A_gene_locus_splicing.png|UGT1A 基因座位剪接模式]]</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <br>UGT1A 基因座全长约 200 kb。它包含多个独特的<strong>第一外显子</strong>（Exon 1），每个 Exon 1 拥有独立的启动子。这些 Exon 1 均与下游共享的 Exon 2-5 拼接。[[Image:UGT1A_gene_locus_splicing.png<ins class="diffchange diffchange-inline">|100px</ins>|UGT1A 基因座位剪接模式]]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <br><em>意义：</em> 这种结构使得同一个基因座可以通过选择不同的 Exon 1，产生底物特异性完全不同的酶（如 UGT1A1 专攻胆红素，UGT1A9 专攻酚类药物）。</li></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <br><em>意义：</em> 这种结构使得同一个基因座可以通过选择不同的 Exon 1，产生底物特异性完全不同的酶（如 UGT1A1 专攻胆红素，UGT1A9 专攻酚类药物）。</li></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 12px;"><strong>胆红素的“解毒剂”：</strong></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 12px;"><strong>胆红素的“解毒剂”：</strong></div></td></tr>
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77921020
https://www.yiliao.com/index.php?title=UGT1A&diff=312226&oldid=prev
77921020：建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面
2025-12-31T14:45:07Z
<p>建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面</p>
<p><b>新页面</b></p><div><div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff; max-width: 1200px; margin: auto;"><br />
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<strong>UGT1A</strong>（UDP-Glucuronosyltransferase 1A）并非指代单一基因，而是一个位于 2 号染色体上的庞大<strong>基因复合物</strong>（Gene Complex）。该座位通过独特的“可变外显子”剪接机制，编码了 9 种具有功能的酶异构体（如 UGT1A1, UGT1A3, UGT1A9 等）。其中，<strong>[[UGT1A1]]</strong> 是临床上最重要的一员，因为它是人体内唯一负责<strong>[[胆红素]]</strong>葡萄糖醛酸化的酶。UGT1A1 的功能缺陷直接导致胆红素代谢障碍，引发从良性的<strong>[[吉尔伯特综合征]]</strong>到致死性的<strong>[[克里格勒-纳贾尔综合征]]</strong>等一系列疾病。此外，UGT1A1 也是化疗药物<strong>[[依立替康]]</strong> (Irinotecan) 的关键代谢酶，其基因多态性（如 *28 等位基因）是预测化疗毒性的“金标准”。<br />
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<div style="font-size: 1.2em; font-weight: bold; letter-spacing: 1.2px;">UGT1A (Focus: UGT1A1)</div><br />
<div style="font-size: 0.7em; opacity: 0.85; margin-top: 4px; white-space: nowrap;">Gene Complex Profile (点击展开)</div><br />
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[[Image:Bilirubin_metabolism_pathway.png|100px|胆红素代谢途径]]<br />
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<div style="font-size: 0.8em; color: #64748b; margin-top: 12px; font-weight: 600;">二相代谢酶 / 胆红素清除</div><br />
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<th style="text-align: left; padding: 8px 12px; border-bottom: 1px solid #f1f5f9; color: #475569; background-color: #f8fafc; width: 40%;">基因座位</th><br />
<td style="padding: 8px 12px; border-bottom: 1px solid #f1f5f9; color: #0f172a;"><strong>UGT1A Complex</strong></td><br />
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<th style="text-align: left; padding: 8px 12px; border-bottom: 1px solid #f1f5f9; color: #475569; background-color: #f8fafc;">核心成员</th><br />
<td style="padding: 8px 12px; border-bottom: 1px solid #f1f5f9; color: #0f172a;"><strong>UGT1A1</strong> (主要), UGT1A9</td><br />
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<th style="text-align: left; padding: 8px 12px; border-bottom: 1px solid #f1f5f9; color: #475569; background-color: #f8fafc;">染色体位置</th><br />
<td style="padding: 8px 12px; border-bottom: 1px solid #f1f5f9; color: #0f172a;">2q37.1</td><br />
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<th style="text-align: left; padding: 8px 12px; border-bottom: 1px solid #f1f5f9; color: #475569; background-color: #f8fafc;">Entrez ID</th><br />
<td style="padding: 8px 12px; border-bottom: 1px solid #f1f5f9; color: #1e40af;">54658 (UGT1A1)</td><br />
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<td style="padding: 8px 12px; border-bottom: 1px solid #f1f5f9; color: #1e40af;">P22309</td><br />
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<th style="text-align: left; padding: 8px 12px; border-bottom: 1px solid #f1f5f9; color: #475569; background-color: #f8fafc;">反应类型</th><br />
<td style="padding: 8px 12px; border-bottom: 1px solid #f1f5f9; color: #0f172a;">葡萄糖醛酸化 (Glucuronidation)</td><br />
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<th style="text-align: left; padding: 8px 12px; color: #475569; background-color: #f8fafc;">关键底物</th><br />
<td style="padding: 8px 12px; color: #0f172a;">[[胆红素]], [[SN-38]], [[酚类]], [[雌激素]]</td><br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">分子机制：二相代谢与基因共享</h2><br />
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UGT1A 家族属于体内最重要的<strong>II相代谢酶</strong>（Phase II Enzymes），负责将葡萄糖醛酸（Glucuronic acid）转移到疏水性毒素或药物上，使其变为水溶性以便通过胆汁或尿液排出。<br />
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<li style="margin-bottom: 12px;"><strong>独特的基因结构 (Exon Sharing)：</strong><br />
<br>UGT1A 基因座全长约 200 kb。它包含多个独特的<strong>第一外显子</strong>（Exon 1），每个 Exon 1 拥有独立的启动子。这些 Exon 1 均与下游共享的 Exon 2-5 拼接。[[Image:UGT1A_gene_locus_splicing.png|UGT1A 基因座位剪接模式]]<br />
<br><em>意义：</em> 这种结构使得同一个基因座可以通过选择不同的 Exon 1，产生底物特异性完全不同的酶（如 UGT1A1 专攻胆红素，UGT1A9 专攻酚类药物）。</li><br />
<li style="margin-bottom: 12px;"><strong>胆红素的“解毒剂”：</strong><br />
<br>衰老红细胞释放的非结合胆红素（Unconjugated Bilirubin）具有神经毒性且难溶于水。<strong>UGT1A1</strong> 是体内唯一能将其转化为结合胆红素（Conjugated Bilirubin）的酶，这是胆红素排泄的限速步骤。</li><br />
<li style="margin-bottom: 12px;"><strong>依立替康代谢 (SN-38 Inactivation)：</strong><br />
<br>化疗药依立替康在体内被激活为剧毒的 SN-38（杀灭肿瘤的活性形式）。UGT1A1 负责将 SN-38 葡萄糖醛酸化为无活性的 SN-38G 并排出。若 UGT1A1 活性低，剧毒的 SN-38 会在体内蓄积，导致严重腹泻和骨髓抑制。</li><br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">临床景观：黄疸与药物毒性</h2><br />
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UGT1A1 的功能状态直接决定了黄疸的严重程度和特定的化疗风险。<br />
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<th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 25%;">疾病/状态</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569;">UGT1A1 活性水平</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af;">临床特征</th><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">[[吉尔伯特综合征]] (Gilbert Syndrome)</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">下降至正常值的 ~30%</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">非常常见（人群 5-10%）。通常无症状，仅在压力、禁食或感染时出现轻度非结合性高胆红素血症。基因型常为启动子区 <strong>UGT1A1*28</strong> (TA重复序列增加)。通常良性，无需治疗。</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">[[克里格勒-纳贾尔综合征]] II型 (CN-II)</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">极低 (<10%)</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">严重黄疸，但对苯巴比妥（酶诱导剂）治疗有反应。通常生活质量尚可，但需警惕。</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">克里格勒-纳贾尔综合征 I型 (CN-I)</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;"><strong>完全缺失 (0%)</strong></td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">致死性。出生即出现极重度黄疸，面临极高的<strong>[[核黄疸]]</strong> (Kernicterus) 风险，导致脑损伤。对苯巴比妥无效，需光疗或肝移植。</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">[[依立替康毒性]]</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">因基因型而异 (*28/*6)</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">携带 *28 等位基因（纯合子 UGT1A1*28/*28）的患者，代谢 SN-38 能力差。使用常规剂量依立替康极易发生<strong>4级中性粒细胞减少</strong>和迟发性严重腹泻。</td><br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">药物基因组学与治疗策略</h2><br />
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<li style="margin-bottom: 12px;"><strong>依立替康剂量调整：</strong><br />
<br>FDA 标签建议：对于 <strong>UGT1A1*28</strong> 纯合子患者，应降低依立替康的起始剂量（通常降低一级），以预防致命毒性。在亚洲人群中，<strong>UGT1A1*6</strong> 变异同样重要且常见。</li><br />
<li style="margin-bottom: 12px;"><strong>新生儿黄疸管理：</strong><br />
<br>对于 CN-I 型患者，目前的标准治疗是每日长时间的蓝光照射（光疗）和血浆置换，终极治疗是肝移植。基因治疗（补充正常的 UGT1A1）正在临床试验中。</li><br />
<li style="margin-bottom: 12px;"><strong>Atazanavir 黄疸：</strong><br />
<br>抗 HIV 药物 Atazanavir 是一种 UGT1A1 抑制剂。吉尔伯特综合征患者服用该药极易出现黄疸，虽无毒性但影响美观，常导致患者自行停药。</li><br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">关键关联概念</h2><br />
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<li style="margin-bottom: 12px;"><strong>[[葡萄糖醛酸化]]：</strong> II 相代谢中最主要的解毒反应。</li><br />
<li style="margin-bottom: 12px;"><strong>[[核黄疸]] (Kernicterus)：</strong> 游离胆红素穿过血脑屏障沉积于基底节，造成不可逆脑损伤。</li><br />
<li style="margin-bottom: 12px;"><strong>[[SN-38]]：</strong> 依立替康的活性代谢物，毒性极大，依赖 UGT1A1 清除。</li><br />
<li style="margin-bottom: 12px;"><strong>[[UGT1A1*28]]：</strong> 启动子区 TA 重复序列由 6 个变为 7 个 ((TA)7TAA)，导致转录效率下降。</li><br />
<li style="margin-bottom: 12px;"><strong>[[苯巴比妥]]：</strong> 能够诱导 UGT1A1 表达的药物，用于鉴别 CN-I 和 CN-II 型。</li><br />
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<span style="color: #0f172a; font-weight: bold; font-size: 1.05em; display: inline-block; margin-bottom: 15px;">学术参考文献与权威点评</span><br />
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[1] <strong>Bosma PJ, et al. (1995).</strong> <em>The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome.</em> <strong>[[New England Journal of Medicine]] (NEJM)</strong>. <br><br />
<span style="color: #475569;">[学术点评]：吉尔伯特综合征的解密。该研究首次发现 UGT1A1 启动子区的 A(TA)6TAA 序列插入额外的 TA 导致 A(TA)7TAA（即 *28 等位基因），是吉尔伯特综合征的主要分子病因。</span><br />
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[2] <strong>Iyer L, et al. (1998).</strong> <em>UGT1A1*28 polymorphism as a determinant of irinotecan disposition and toxicity.</em> <strong>[[Journal of Clinical Investigation]] (JCI)</strong>. <br><br />
<span style="color: #475569;">[学术点评]：药物基因组学里程碑。建立了 UGT1A1 基因型与依立替康代谢（SN-38葡萄糖醛酸化）之间的直接联系，奠定了依立替康个体化给药的理论基础。</span><br />
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[3] <strong>Kadakol A, et al. (2000).</strong> <em>Genetic lesions of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) causing Crigler-Najjar and Gilbert syndromes.</em> <strong>[[Human Mutation]]</strong>. <br><br />
<span style="color: #475569;">[学术点评]：突变谱系。系统总结了导致致死性 CN-I 型和较轻 CN-II 型的各类 UGT1A1 突变（点突变、截短等），提供了基因型-表型相关性的完整图谱。</span><br />
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<div style="background-color: #0f172a; color: #ffffff; text-align: center; font-weight: bold; padding: 10px; letter-spacing: 1px;">UGT1A (UGT1A1) · 知识图谱关联</div><br />
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[[胆红素]] • [[依立替康]] • [[吉尔伯特综合征]] • [[克里格勒-纳贾尔综合征]] • [[核黄疸]] • [[SN-38]] • [[药物基因组学]] • [[II相代谢]] • [[UGT1A9]] • [[苯巴比妥]]<br />
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