14.36.39.47：建立内容为“{{PBB|geneid=5728}} PTEN蛋白（蓝色）与[[酒石酸（棕色）复合的空间结构模型…”的新页面

2021-07-21T18:26:45Z

建立内容为“{{PBB|geneid=5728}} right|thumbnail|270px|PTEN蛋白（蓝色）与[[酒石酸（棕色）复合的空间结构模型<ref name="pmid10555148"/>…”的新页面

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{{PBB|geneid=5728}}
[[File:PTEN.png|right|thumbnail|270px|PTEN蛋白（蓝色）与[[酒石酸]]（棕色）复合的空间结构模型<ref name="pmid10555148"/>。]]

'''[[磷酸酯酶]]与张力[[蛋白]][[同源]]物'''（{{lang-en|Phosphatase and tensin homolog}}，简称为'''PTEN'''）是一种在人体中由''PTEN''[[基因]]编码的[[蛋白质]]<ref name="pmid9090379">{{Cite journal| author = Steck PA, Pershouse MA, Jasser SA, Yung WK, Lin H, Ligon AH, Langford LA, Baumgard ML, Hattier T, Davis T, Frye C, Hu R, Swedlund B, Teng DH, Tavtigian SV | title = Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers | journal = Nat. Genet. | volume = 15 | issue = 4 | pages = 356–62 | year = 1997 | month = April | pmid = 9090379 | doi = 10.1038/ng0497-356 | url = }}</ref>。该基因的[[突变]]是多种[[癌症]]进展过程的环节之一。

''PTEN''通过其[[磷酸酯]][[酶蛋白]]产物而行使一种[[抑癌基因]]的作用。这一磷酸酯酶参与了[[细胞周期]]的调节，阻止[[细胞]]过快地生长与分裂<ref name="pmid15448614">{{Cite journal| author = Chu EC, Tarnawski AS | title = PTEN regulatory functions in tumor suppression and cell biology | journal = Med. Sci. Monit. | volume = 10 | issue = 10 | pages = RA235–41 | year = 2004 | month = October | pmid = 15448614 | doi = | url = http://www.medscimonit.com/fulltxt.php?ICID=11797 }}</ref>。其为癌微RNAMIRN21的靶之一。

该基因被鉴定为一种[[肿瘤]]抑制物，在多种癌症中往往处于[[变异]]状态。该基因编码的蛋白质是一种[[磷脂酰肌醇]]-3,4,5-三[[磷酸]]3-磷酸酯酶。该蛋白同时含有一[[TNS1|张力蛋白]]样[[结构域]]及一[[催化]]结构域，这与双特异性蛋白[[酪氨酸]][[磷酸酶]]很相似。但与大部分蛋白质酪氨酸磷酸酶不同的是，该蛋白偏好脱去[[磷酸肌醇]][[底物]]上的磷酸。该蛋白负性调控胞内[[磷脂酰肌醇(3,4,5)-三磷酸|磷脂酰肌醇-3,4,5-三磷酸]]的水平，并通过负性调控Akt/PKB信号通道发挥抑癌基因的作用<ref>{{Cite web| title = Entrez Gene: PTEN phosphatase and tensin homolog (mutated in multiple advanced cancers 1)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5728| accessdate = }}</ref>。

== 参考文献 ==

{{Reflist|35em}}

==深入阅读==

{{Refbegin|35em}}
* {{Cite journal| author=Li J, Yen C, Liaw D, Podsypanina K, Bose S, Wang SI, Puc J, Miliaresis C, Rodgers L, McCombie R, Bigner SH, Giovanella BC, Ittmann M, Tycko B, Hibshoosh H, Wigler MH, Parsons R | title=PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer | journal=Science | year=1997 | pages=1943–1947 | volume=275 | issue=5308 | pmid=9072974 | doi=10.1126/science.275.5308.1943}}
* {{Cite journal| author=Simpson L, Parsons R | title=PTEN: life as a tumor suppressor
| journal=Exp Cell Res | year=2001 | pages=29–41 | volume=264 | issue=1 | pmid=11237521 | doi=10.1006/excr.2000.5130}}
* {{Cite journal| author=Chu EC, Tarnawski AS | title=PTEN regulatory functions in tumor suppression and cell biology | journal=Med Sci Monit | year=2004 | pages=RA235–41 | volume=10 | issue=10 | pmid=15448614}}
* {{Cite journal| author=Eng C | title=PTEN: one gene, many syndromes | journal=Hum Mutat | year=2003 | pages=183–98 | volume=22 | issue=3 | pmid=12938083 | doi=10.1002/humu.10257}}
* {{Cite journal| author=Hamada K, Sasaki T, Koni PA, Natsui M, Kishimoto H, Sasaki J, Yajima N, Horie Y, Hasegawa G, Naito M, Miyazaki J, Suda T, Itoh H, Nakao K, Mak TW, Nakano T, Suzuki A | title=The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis | journal=Genes Dev | year=2005 | pages=2054–65 | volume=19 | issue=17 | pmid=16107612 | doi=10.1101/gad.1308805 | pmc=1199575}}
* {{Cite journal| author=Leslie NR, Downes CP | title=PTEN function: how normal cells control it and tumour cells lose it | journal=Biochem J | year=2004 | pages=1–11 | volume=382 | issue=Pt 1 | pmid=15193142 | doi=10.1042/BJ20040825 | pmc=1133909}}
* {{Cite journal| author=Pilarski R, Eng C | title=Will the real Cowden syndrome please stand up (again)? Expanding mutational and clinical spectra of the PTEN hamartoma tumour syndrome | journal=J Med Genet | year=2004 | pages=323–6 | volume=41 | issue=5 | pmid=15121767 | doi=10.1136/jmg.2004.018036 | pmc=1735782}}
* {{Cite journal| author=Sansal I, Sellers WR | title=The biology and clinical relevance of the PTEN tumor suppressor pathway | journal=J Clin Oncol | year=2004 | pages=2954–63 | volume=22 | issue=14 | pmid=15254063 | doi=10.1200/JCO.2004.02.141}}
* {{Cite journal| author=Waite KA, Eng C | title=Protean PTEN: Form and Function | journal=Am J Hum Genet | year=2002 | pages=829–44 | volume=70 | issue=4 | pmid=11875759 | doi=10.1086/340026 | pmc=379112}}
* {{Cite journal| author=Zhou XP, Waite KA, Pilarski R, Hampel H, Fernandez MJ, Bos C, Dasouki M, Feldman GL, Greenberg LA, Ivanovich J, Matloff E, Patterson A, Pierpont ME, Russo D, Nassif NT, Eng C | title=Germline PTEN Promoter Mutations and Deletions in Cowden/Bannayan-Riley-Ruvalcaba Syndrome Result in Aberrant PTEN Protein and Dysregulation of the Phosphoinositol-3-Kinase/Akt Pathway | journal=Am J Hum Genet | year=2003 | pages=404–11 | volume=73 | issue=2 | pmid=12844284 | doi=10.1086/377109 | pmc=1180378}}
* {{Cite journal| author=Ji S-P, Zhang Y, Cleemput JV, Jiang W, Liao M, Li L, Wan Q, Backstrom JR, Zhang X | title=Disruption of PTEN coupling with 5-HT2C receptors suppresses behavioral responses induced by drugs of abuse | journal=Nature Medicine | year=2006 | pages=324–9 | volume=12 | issue=3 | pmid=16474401 | doi=10.1038/nm1349}}
{{Refend}}

==外部链接==
* [http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=phts GeneReviews/NCBI/NIH/UW entry on PTEN Hamartoma Tumor Syndrome (PHTS)]
* {{MeshName|PTEN+Protein}}
* {{UMichOPM|protein|pdbid|1d5r}}
* {{Cite web| url = http://www.genecards.org/cgi-bin/carddisp.pl?gene=PTEN | title = PTEN Gene - phosphatase and tensin homolog | author = | authorlink = | coauthors = | date = | format = | work = GeneCards | publisher = The Weizmann Institute of Science | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2009-03-12}}
* {{Cite web| url = http://www.alzforum.org/res/com/gen/alzgene/geneoverview.asp?geneid=351 | title = Gene overview of all published AD-association studies for PTEN | author = | authorlink = | coauthors = | date = | format = | work = Alzforum: AlzGene | publisher = Alzheimer Research Forum | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2009-03-12}}
*[http://www.ucdmc.ucdavis.edu/publish/news/mindinstitute/6866 Research shows gene defect's role in autism-like behavior]
{{NLM content}}
{{PDB Gallery|geneid=5728}}
{{蛋白酪氨酸磷酸酶类}}
{{磷酸酯酶类}}
{{抑癌基因}}

[[Category:人类蛋白质]]

[[Category:肿瘤抑制基因]] [[Category:外周膜蛋白]] [[Category:EC 3.1.3]]
==参考来源==
*[http://zh.wikipedia.org/wiki/PTEN_%28%E5%9F%BA%E5%9B%A0%29 维基百科-PTEN (基因)]

PTEN (基因) - 版本历史

14.36.39.47：建立内容为“{{PBB|geneid=5728}} PTEN蛋白（蓝色）与[[酒石酸（棕色）复合的空间结构模型…”的新页面