https://www.yiliao.com/index.php?action=history&feed=atom&title=P40 2026-04-18T16:36:41Z 本wiki的该页面的版本历史 MediaWiki 1.35.1 https://www.yiliao.com/index.php?title=P40&diff=315703&oldid=prev 2026-01-26T02:18:19Z

<p></p> <table class="diff diff-contentalign-left diff-editfont-monospace" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="zh-Hans-CN"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2026年1月26日 (一) 02:18的版本</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l11" >第11行：</td> <td colspan="2" class="diff-lineno">第11行：</td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                 &lt;div&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                 &lt;div&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;h2 style=&quot;margin: 0 0 8px 0; font-size: 1.4em; color: #1e40af;&quot;&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;h2 style=&quot;margin: 0 0 8px 0; font-size: 1.4em; color: #1e40af;&quot;&gt;</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>                         &lt;<del class="diffchange diffchange-inline">a href=&quot;wiki/P40_(Pathology)&quot; style=&quot;text-decoration: none; color: inherit;&quot;</del>&gt;[[P40 (病理学)]]&lt;/<del class="diffchange diffchange-inline">a</del>&gt;</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>                         &lt;<ins class="diffchange diffchange-inline">strong</ins>&gt;[[P40 (病理学)]]&lt;/<ins class="diffchange diffchange-inline">strong</ins>&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;/h2&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;/h2&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;span style=&quot;display: inline-block; background-color: #dbeafe; color: #1e40af; padding: 2px 8px; border-radius: 4px; font-size: 0.8em; font-weight: 600; margin-bottom: 8px;&quot;&gt;&amp;Delta;Np63 蛋白&lt;/span&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;span style=&quot;display: inline-block; background-color: #dbeafe; color: #1e40af; padding: 2px 8px; border-radius: 4px; font-size: 0.8em; font-weight: 600; margin-bottom: 8px;&quot;&gt;&amp;Delta;Np63 蛋白&lt;/span&gt;</div></td></tr> <tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l29" >第29行：</td> <td colspan="2" class="diff-lineno">第29行：</td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                 &lt;div&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                 &lt;div&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;h2 style=&quot;margin: 0 0 8px 0; font-size: 1.4em; color: #065f46;&quot;&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;h2 style=&quot;margin: 0 0 8px 0; font-size: 1.4em; color: #065f46;&quot;&gt;</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>                         &lt;<del class="diffchange diffchange-inline">a href=&quot;wiki/P40_(Immunology)&quot; style=&quot;text-decoration: none; color: inherit;&quot;</del>&gt;[[P40 (免疫学)]]&lt;/<del class="diffchange diffchange-inline">a</del>&gt;</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>                         &lt;<ins class="diffchange diffchange-inline">strong</ins>&gt;[[P40 (免疫学)]]&lt;/<ins class="diffchange diffchange-inline">strong</ins>&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;/h2&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;/h2&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;span style=&quot;display: inline-block; background-color: #d1fae5; color: #065f46; padding: 2px 8px; border-radius: 4px; font-size: 0.8em; font-weight: 600; margin-bottom: 8px;&quot;&gt;IL-12B / 细胞因子亚基&lt;/span&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;span style=&quot;display: inline-block; background-color: #d1fae5; color: #065f46; padding: 2px 8px; border-radius: 4px; font-size: 0.8em; font-weight: 600; margin-bottom: 8px;&quot;&gt;IL-12B / 细胞因子亚基&lt;/span&gt;</div></td></tr> </table>

77921020 https://www.yiliao.com/index.php?title=P40&diff=315700&oldid=prev 2026-01-26T02:15:56Z

<p></p> <table class="diff diff-contentalign-left diff-editfont-monospace" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="zh-Hans-CN"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2026年1月26日 (一) 02:15的版本</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l3" >第3行：</td> <td colspan="2" class="diff-lineno">第3行：</td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>     &lt;div style=&quot;margin-bottom: 40px; border-bottom: 1.2px solid #e2e8f0; padding-bottom: 20px; text-align: center;&quot;&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>     &lt;div style=&quot;margin-bottom: 40px; border-bottom: 1.2px solid #e2e8f0; padding-bottom: 20px; text-align: center;&quot;&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>         &lt;h1 style=&quot;font-size: 2.2em; color: #1e40af; margin-bottom: 10px; font-weight: bold;&quot;&gt;P40&lt;/h1&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>         &lt;h1 style=&quot;font-size: 2.2em; color: #1e40af; margin-bottom: 10px; font-weight: bold;&quot;&gt;P40&lt;/h1&gt;</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>         &lt;p style=&quot;font-size: 1.1em; color: #64748b; margin: 0;&quot;&gt;这是一个&lt;span style=&quot;color: #0f172a; font-weight: 600;&quot;&gt;消歧义&lt;/span&gt;页面。P40 <del class="diffchange diffchange-inline">在医学中可能指代以下不同的分子或概念：</del>&lt;/p&gt;</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>         &lt;p style=&quot;font-size: 1.1em; color: #64748b; margin: 0;&quot;&gt;这是一个&lt;span style=&quot;color: #0f172a; font-weight: 600;&quot;&gt;消歧义&lt;/span&gt;页面。P40 <ins class="diffchange diffchange-inline">在医学中可能指代以下不同的分子：</ins>&lt;/p&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>     &lt;/div&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>     &lt;/div&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>     &lt;div style=&quot;margin-bottom: 20px; border: 1px solid #cbd5e1; border-radius: 12px; overflow: hidden<del class="diffchange diffchange-inline">; transition: all 0.3s ease</del>; box-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.05);&quot;&gt;</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>     &lt;div style=&quot;margin-bottom: 20px; border: 1px solid #cbd5e1; border-radius: 12px; overflow: hidden; box-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.05);&quot;&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>         &lt;div style=&quot;padding: 20px 25px; background: linear-gradient(to right, #eff6ff, #ffffff); border-left: 6px solid #1e40af;&quot;&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>         &lt;div style=&quot;padding: 20px 25px; background: linear-gradient(to right, #eff6ff, #ffffff); border-left: 6px solid #1e40af;&quot;&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>             &lt;div style=&quot;display: flex; align-items: center; justify-content: space-between;&quot;&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>             &lt;div style=&quot;display: flex; align-items: center; justify-content: space-between;&quot;&gt;</div></td></tr> <tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l13" >第13行：</td> <td colspan="2" class="diff-lineno">第13行：</td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                         &lt;a href=&quot;wiki/P40_(Pathology)&quot; style=&quot;text-decoration: none; color: inherit;&quot;&gt;[[P40 (病理学)]]&lt;/a&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                         &lt;a href=&quot;wiki/P40_(Pathology)&quot; style=&quot;text-decoration: none; color: inherit;&quot;&gt;[[P40 (病理学)]]&lt;/a&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;/h2&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;/h2&gt;</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;span style=&quot;display: inline-block; background-color: #dbeafe; color: #1e40af; padding: 2px 8px; border-radius: 4px; font-size: 0.8em; font-weight: 600; margin-bottom: 8px;&quot;&gt;<del class="diffchange diffchange-inline">ΔNp63 </del>蛋白&lt;/span&gt;</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;span style=&quot;display: inline-block; background-color: #dbeafe; color: #1e40af; padding: 2px 8px; border-radius: 4px; font-size: 0.8em; font-weight: 600; margin-bottom: 8px;&quot;&gt;<ins class="diffchange diffchange-inline">&amp;Delta;Np63 </ins>蛋白&lt;/span&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;p style=&quot;margin: 5px 0 0 0; color: #475569; font-size: 0.95em;&quot;&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;p style=&quot;margin: 5px 0 0 0; color: #475569; font-size: 0.95em;&quot;&gt;</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>                         即 &lt;strong&gt;<del class="diffchange diffchange-inline">ΔNp63</del>&lt;/strong&gt;。一种核转录因子，&lt;strong&gt;[[TP63]]&lt;/strong&gt; 基因的异构体。</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>                         即 &lt;strong&gt;<ins class="diffchange diffchange-inline">&amp;Delta;Np63</ins>&lt;/strong&gt; <ins class="diffchange diffchange-inline">(Delta-N p63)</ins>。一种核转录因子，&lt;strong&gt;[[TP63]]&lt;/strong&gt; 基因的异构体。</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                         &lt;br&gt;&lt;strong&gt;临床用途：&lt;/strong&gt; 作为免疫组化（IHC）标志物，是诊断&lt;strong&gt;[[肺鳞癌]]&lt;/strong&gt;的金标准，用于区分肺腺癌（阴性）和鳞癌（阳性）。</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                         &lt;br&gt;&lt;strong&gt;临床用途：&lt;/strong&gt; 作为免疫组化（IHC）标志物，是诊断&lt;strong&gt;[[肺鳞癌]]&lt;/strong&gt;的金标准，用于区分肺腺癌（阴性）和鳞癌（阳性）。</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;/p&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;/p&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                 &lt;/div&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                 &lt;/div&gt;</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>                 &lt;div style=&quot;font-size: <del class="diffchange diffchange-inline">2.5em</del>; <del class="diffchange diffchange-inline">opacity</del>: <del class="diffchange diffchange-inline">0.2</del>; margin-left: 20px;&quot;&gt;<del class="diffchange diffchange-inline">🔬</del>&lt;/div&gt;</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>                 &lt;div style=&quot;font-size: <ins class="diffchange diffchange-inline">2em</ins>; <ins class="diffchange diffchange-inline">color</ins>: <ins class="diffchange diffchange-inline">#cbd5e1</ins>; margin-left: 20px;&quot;&gt;<ins class="diffchange diffchange-inline">[病理]</ins>&lt;/div&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>             &lt;/div&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>             &lt;/div&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>         &lt;/div&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>         &lt;/div&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>     &lt;/div&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>     &lt;/div&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>     &lt;div style=&quot;margin-bottom: 20px; border: 1px solid #cbd5e1; border-radius: 12px; overflow: hidden<del class="diffchange diffchange-inline">; transition: all 0.3s ease</del>; box-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.05);&quot;&gt;</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>     &lt;div style=&quot;margin-bottom: 20px; border: 1px solid #cbd5e1; border-radius: 12px; overflow: hidden; box-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.05);&quot;&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>         &lt;div style=&quot;padding: 20px 25px; background: linear-gradient(to right, #f0fdf4, #ffffff); border-left: 6px solid #059669;&quot;&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>         &lt;div style=&quot;padding: 20px 25px; background: linear-gradient(to right, #f0fdf4, #ffffff); border-left: 6px solid #059669;&quot;&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>             &lt;div style=&quot;display: flex; align-items: center; justify-content: space-between;&quot;&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>             &lt;div style=&quot;display: flex; align-items: center; justify-content: space-between;&quot;&gt;</div></td></tr> <tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l37" >第37行：</td> <td colspan="2" class="diff-lineno">第37行：</td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;/p&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                     &lt;/p&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                 &lt;/div&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>                 &lt;/div&gt;</div></td></tr> <tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>                 &lt;div style=&quot;font-size: <del class="diffchange diffchange-inline">2.5em</del>; <del class="diffchange diffchange-inline">opacity</del>: <del class="diffchange diffchange-inline">0.2</del>; margin-left: 20px;&quot;&gt;<del class="diffchange diffchange-inline">🛡️</del>&lt;/div&gt;</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>                 &lt;div style=&quot;font-size: <ins class="diffchange diffchange-inline">2em</ins>; <ins class="diffchange diffchange-inline">color</ins>: <ins class="diffchange diffchange-inline">#cbd5e1</ins>; margin-left: 20px;&quot;&gt;<ins class="diffchange diffchange-inline">[免疫]</ins>&lt;/div&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>             &lt;/div&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>             &lt;/div&gt;</div></td></tr> <tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>         &lt;/div&gt;</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>         &lt;/div&gt;</div></td></tr> </table>

77921020 https://www.yiliao.com/index.php?title=P40&diff=315698&oldid=prev 2026-01-26T02:13:37Z

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218.108.119.226 https://www.yiliao.com/index.php?title=P40&diff=314741&oldid=prev 2026-01-17T21:04:37Z

<p>建立内容为“&lt;div style=&quot;padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: &#039;Helvetica Neue&#039;, Helvetica, &#039;PingFang SC&#039;, Arial, sans-serif; background-color: #ffffff…”的新页面</p> <p><b>新页面</b></p><div>&lt;div style=&quot;padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff; max-width: 1200px; margin: auto;&quot;&gt;<br /> <br /> &lt;div style=&quot;margin-bottom: 30px; border-bottom: 1.2px solid #e2e8f0; padding-bottom: 25px;&quot;&gt;<br /> &lt;p style=&quot;font-size: 1.1em; margin: 10px 0; color: #334155; text-align: justify;&quot;&gt;<br /> &lt;strong&gt;IL-12&lt;/strong&gt;（Interleukin-12，白细胞介素-12）是免疫学中至关重要的促炎细胞因子，被誉为连接先天免疫与适应性免疫的&lt;strong&gt;“指挥官”&lt;/strong&gt;。它主要由抗原提呈细胞（如[[树突状细胞]]、巨噬细胞）产生，核心功能是诱导初始 CD4+ T 细胞分化为 &lt;strong&gt;[[Th1细胞]]&lt;/strong&gt;，并刺激 T 细胞和 NK 细胞大量分泌 &lt;strong&gt;[[IFN-γ]]&lt;/strong&gt;（干扰素-γ），从而启动针对胞内病原体（如结核杆菌、病毒）和肿瘤的细胞免疫反应。在结构上，IL-12 是独特的&lt;strong&gt;异源二聚体&lt;/strong&gt;，由 &lt;strong&gt;p35&lt;/strong&gt; (IL12A) 和 &lt;strong&gt;p40&lt;/strong&gt; (IL12B) 两个亚基组成。值得注意的是，p40 亚基也被另一种致炎因子 &lt;strong&gt;[[IL-23]]&lt;/strong&gt; 所共用，这一发现彻底重塑了自身免疫病的药物开发策略。<br /> &lt;/p&gt;<br /> &lt;/div&gt;<br /> <br /> &lt;div class=&quot;medical-infobox mw-collapsible mw-collapsed&quot; style=&quot;width: 320px; float: right; margin: 0 0 25px 25px; border: 1.2px solid #bae6fd; border-radius: 12px; background-color: #ffffff; box-shadow: 0 8px 20px rgba(0,0,0,0.05); overflow: hidden;&quot;&gt;<br /> <br /> &lt;div style=&quot;padding: 15px; color: #1e40af; background: linear-gradient(135deg, #e0f2fe 0%, #ffffff 100%); text-align: center; cursor: pointer;&quot;&gt;<br /> &lt;div style=&quot;font-size: 1.2em; font-weight: bold; letter-spacing: 1.2px;&quot;&gt;IL-12 (p70)&lt;/div&gt;<br /> &lt;div style=&quot;font-size: 0.75em; opacity: 0.85; margin-top: 4px;&quot;&gt;Key Th1 Cytokine Profile · 点击展开&lt;/div&gt;<br /> &lt;/div&gt;<br /> <br /> &lt;div class=&quot;mw-collapsible-content&quot;&gt;<br /> &lt;div style=&quot;padding: 20px; text-align: center; background-color: #f8fafc;&quot;&gt;<br /> &lt;div style=&quot;padding: 12px; border: 1px solid #e2e8f0; border-radius: 8px; background: #fff; display: inline-block;&quot;&gt;<br /> &lt;div style=&quot;width: 140px; height: 90px; background-color: #f1f5f9; display: flex; align-items: center; justify-content: center; color: #94a3b8; font-size: 0.8em; padding: 10px; text-align: center;&quot;&gt;&lt;/div&gt;<br /> &lt;/div&gt;<br /> &lt;div style=&quot;font-size: 0.8em; color: #64748b; margin-top: 12px; font-weight: 600;&quot;&gt;Th1 诱导剂 / 异源二聚体&lt;/div&gt;<br /> &lt;/div&gt;<br /> <br /> &lt;table style=&quot;width: 100%; border-spacing: 0; border-collapse: collapse; font-size: 0.85em;&quot;&gt;<br /> &lt;tr&gt;<br /> &lt;th style=&quot;text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; width: 45%;&quot;&gt;基因符号&lt;/th&gt;<br /> &lt;td style=&quot;padding: 8px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;&quot;&gt;&lt;strong&gt;IL12A&lt;/strong&gt; (p35) / &lt;strong&gt;IL12B&lt;/strong&gt; (p40)&lt;/td&gt;<br /> &lt;/tr&gt;<br /> &lt;tr&gt;<br /> &lt;th style=&quot;text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;&quot;&gt;蛋白类型&lt;/th&gt;<br /> &lt;td style=&quot;padding: 8px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;&quot;&gt;I型细胞因子 (异源二聚体)&lt;/td&gt;<br /> &lt;/tr&gt;<br /> &lt;tr&gt;<br /> &lt;th style=&quot;text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;&quot;&gt;染色体位置&lt;/th&gt;<br /> &lt;td style=&quot;padding: 8px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;&quot;&gt;3q25.33 (p35) / 5q31.1 (p40)&lt;/td&gt;<br /> &lt;/tr&gt;<br /> &lt;tr&gt;<br /> &lt;th style=&quot;text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;&quot;&gt;Entrez ID&lt;/th&gt;<br /> &lt;td style=&quot;padding: 8px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;&quot;&gt;3592 (A) / 3593 (B)&lt;/td&gt;<br /> &lt;/tr&gt;<br /> &lt;tr&gt;<br /> &lt;th style=&quot;text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;&quot;&gt;OMIM ID&lt;/th&gt;<br /> &lt;td style=&quot;padding: 8px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;&quot;&gt;614891 (缺陷症)&lt;/td&gt;<br /> &lt;/tr&gt;<br /> &lt;tr&gt;<br /> &lt;th style=&quot;text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;&quot;&gt;主要来源&lt;/th&gt;<br /> &lt;td style=&quot;padding: 8px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;&quot;&gt;[[树突状细胞]] (DC), 巨噬细胞&lt;/td&gt;<br /> &lt;/tr&gt;<br /> &lt;tr&gt;<br /> &lt;th style=&quot;text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;&quot;&gt;信号通路&lt;/th&gt;<br /> &lt;td style=&quot;padding: 8px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;&quot;&gt;JAK2/TYK2 -&gt; [[STAT4]]&lt;/td&gt;<br /> &lt;/tr&gt;<br /> &lt;tr&gt;<br /> &lt;th style=&quot;text-align: left; padding: 8px 12px; background-color: #f1f5f9; color: #475569;&quot;&gt;抑制药物&lt;/th&gt;<br /> &lt;td style=&quot;padding: 12px; color: #0f172a;&quot;&gt;[[乌司奴单抗]], [[Briakinumab]]&lt;/td&gt;<br /> &lt;/tr&gt;<br /> &lt;/table&gt;<br /> &lt;/div&gt;<br /> &lt;/div&gt;<br /> <br /> &lt;h2 style=&quot;background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;&quot;&gt;分子机制：JAK-STAT 与 Th1 定型&lt;/h2&gt;<br /> <br /> &lt;p style=&quot;margin: 15px 0; text-align: justify;&quot;&gt;<br /> IL-12 是决定免疫系统“细胞杀伤”战略的关键决策分子：<br /> &lt;/p&gt;<br /> &lt;ul style=&quot;padding-left: 25px; color: #334155;&quot;&gt;<br /> &lt;li style=&quot;margin-bottom: 12px;&quot;&gt;&lt;strong&gt;异源二聚体结构：&lt;/strong&gt;<br /> &lt;br&gt;IL-12 是由两个共价连接的亚基组成的 70 kDa 蛋白质 (p70)。<br /> &lt;br&gt;&lt;strong&gt;p35 (IL12A)：&lt;/strong&gt; 结构上类似 IL-6，在大多数细胞中不单独分泌。<br /> &lt;br&gt;&lt;strong&gt;p40 (IL12B)：&lt;/strong&gt; 结构上类似受体，可过量分泌。它不仅是 IL-12 的一部分，也是 &lt;strong&gt;[[IL-23]]&lt;/strong&gt; (p40 + p19) 的组成部分。&lt;/li&gt;<br /> &lt;li style=&quot;margin-bottom: 12px;&quot;&gt;&lt;strong&gt;JAK-STAT 信号传导：&lt;/strong&gt;<br /> &lt;br&gt;IL-12 结合高亲和力受体复合物（IL-12Rβ1 和 IL-12Rβ2）。<br /> &lt;br&gt;&lt;em&gt;激活级联：&lt;/em&gt; 受体偶联的 JAK2 和 TYK2 激酶发生磷酸化 -&gt; 招募并磷酸化 &lt;strong&gt;[[STAT4]]&lt;/strong&gt; -&gt; STAT4 二聚体入核。<br /> <br /> &lt;br&gt;&lt;em&gt;效应：&lt;/em&gt; 强力诱导 &lt;strong&gt;[[IFN-γ]]&lt;/strong&gt; 的转录，同时促进 T-bet 表达，使 T 细胞向 &lt;strong&gt;[[Th1]]&lt;/strong&gt; 亚群定型。&lt;/li&gt;<br /> &lt;/ul&gt;<br /> <br /> &lt;h2 style=&quot;background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;&quot;&gt;前沿应用：局部免疫激活与装甲 CAR-T&lt;/h2&gt;<br /> &lt;p style=&quot;margin: 15px 0; text-align: justify;&quot;&gt;<br /> 鉴于全身给药 IL-12 的毒性，目前的研究热点集中在&lt;strong&gt;“局部递送”&lt;/strong&gt;策略，旨在将“冷肿瘤”转化为“热肿瘤”而不引起细胞因子风暴。<br /> &lt;/p&gt;<br /> <br /> &lt;ul style=&quot;padding-left: 25px; color: #334155;&quot;&gt;<br /> &lt;li style=&quot;margin-bottom: 12px;&quot;&gt;&lt;strong&gt;装甲型 CAR-T (Armored CAR-T / TRUCKs)：&lt;/strong&gt;<br /> &lt;br&gt;即第四代 CAR-T 细胞，被基因工程改造以在肿瘤微环境中诱导分泌 IL-12。<br /> &lt;br&gt;&lt;em&gt;逻辑：&lt;/em&gt; 当 CAR 识别肿瘤抗原后，启动 NFAT 信号通路合成 IL-12。<br /> &lt;br&gt;&lt;em&gt;效应：&lt;/em&gt; 局部高浓度的 IL-12 能够：1. 逆转肿瘤微环境中的免疫抑制（将 M2 型巨噬细胞重极化为 M1 型）；2. 招募内源性 NK 细胞和巨噬细胞杀伤&lt;strong&gt;抗原阴性&lt;/strong&gt;的肿瘤细胞。&lt;/li&gt;<br /> &lt;li style=&quot;margin-bottom: 12px;&quot;&gt;&lt;strong&gt;溶瘤病毒与疫苗：&lt;/strong&gt;<br /> &lt;br&gt;利用溶瘤病毒（如 HSV-1）或 mRNA/DNA 电转导（如 [[TAVO]]）在肿瘤局部表达 IL-12。&lt;/li&gt;<br /> &lt;/ul&gt;<br /> <br /> &lt;h2 style=&quot;background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;&quot;&gt;临床景观：双刃剑效应&lt;/h2&gt;<br /> <br /> &lt;div style=&quot;overflow-x: auto; margin: 25px auto; width: 95%;&quot;&gt;<br /> &lt;table style=&quot;width: 100%; border-collapse: collapse; border: 1.2px solid #cbd5e1; font-size: 0.9em; text-align: left;&quot;&gt;<br /> &lt;tr style=&quot;background-color: #f8fafc; border-bottom: 2px solid #0f172a;&quot;&gt;<br /> &lt;th style=&quot;padding: 10px; border: 1px solid #cbd5e1; color: #0f172a; width: 25%;&quot;&gt;领域&lt;/th&gt;<br /> &lt;th style=&quot;padding: 10px; border: 1px solid #cbd5e1; color: #475569;&quot;&gt;病理机制/现象&lt;/th&gt;<br /> &lt;th style=&quot;padding: 10px; border: 1px solid #cbd5e1; color: #1e40af;&quot;&gt;临床意义&lt;/th&gt;<br /> &lt;/tr&gt;<br /> &lt;tr&gt;<br /> &lt;td style=&quot;padding: 8px; border: 1px solid #cbd5e1; font-weight: 600;&quot;&gt;[[银屑病]] / [[克罗恩病]]&lt;/td&gt;<br /> &lt;td style=&quot;padding: 8px; border: 1px solid #cbd5e1;&quot;&gt;IL-12/IL-23 轴过度激活&lt;/td&gt;<br /> &lt;td style=&quot;padding: 8px; border: 1px solid #cbd5e1;&quot;&gt;抗 p40 单抗（&lt;strong&gt;[[乌司奴单抗]]&lt;/strong&gt;）通过同时阻断两者，成为治疗中重度银屑病和克罗恩病的“金标准”生物制剂。&lt;/td&gt;<br /> &lt;/tr&gt;<br /> &lt;tr&gt;<br /> &lt;td style=&quot;padding: 8px; border: 1px solid #cbd5e1; font-weight: 600;&quot;&gt;[[肿瘤免疫]]&lt;/td&gt;<br /> &lt;td style=&quot;padding: 8px; border: 1px solid #cbd5e1;&quot;&gt;抗肿瘤 vs 毒性&lt;/td&gt;<br /> &lt;td style=&quot;padding: 8px; border: 1px solid #cbd5e1;&quot;&gt;IL-12 能极强地激活 NK 和 CTL 清除肿瘤。然而，全身给药会导致致命的&lt;strong&gt;细胞因子风暴&lt;/strong&gt;样毒性。目前的策略转向“瘤内注射”。&lt;/td&gt;<br /> &lt;/tr&gt;<br /> &lt;tr&gt;<br /> &lt;td style=&quot;padding: 8px; border: 1px solid #cbd5e1; font-weight: 600;&quot;&gt;孟德尔遗传易感性 (MSMD)&lt;/td&gt;<br /> &lt;td style=&quot;padding: 8px; border: 1px solid #cbd5e1;&quot;&gt;IL-12Rβ1 或 p40 缺失&lt;/td&gt;<br /> &lt;td style=&quot;padding: 8px; border: 1px solid #cbd5e1;&quot;&gt;患者对常见的病毒和细菌有抵抗力，但&lt;strong&gt;特异性地易感&lt;/strong&gt;于弱毒力的分枝杆菌（如 [[卡介苗]] BCG）和沙门氏菌。&lt;/td&gt;<br /> &lt;/tr&gt;<br /> &lt;/table&gt;<br /> &lt;/div&gt;<br /> <br /> &lt;div style=&quot;font-size: 0.92em; line-height: 1.6; color: #1e293b; margin-top: 50px; border-top: 2.2px solid #0f172a; padding: 15px 25px; background-color: #f8fafc; border-radius: 0 0 10px 10px;&quot;&gt;<br /> &lt;span style=&quot;color: #0f172a; font-weight: bold; font-size: 1.05em; display: inline-block; margin-bottom: 15px;&quot;&gt;学术参考文献与权威点评&lt;/span&gt;<br /> <br /> &lt;p style=&quot;margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;&quot;&gt;<br /> [1] &lt;strong&gt;Kobayashi M, et al. (1989).&lt;/strong&gt; &lt;em&gt;Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes.&lt;/em&gt; &lt;strong&gt;[[Journal of Experimental Medicine]]&lt;/strong&gt;. &lt;br&gt;<br /> &lt;span style=&quot;color: #475569;&quot;&gt;[学术点评]：发现之源。首次纯化并鉴定了 NKSF（后来命名为 IL-12），揭示了其作为 NK 细胞强效激活剂的功能。&lt;/span&gt;<br /> &lt;/p&gt;<br /> <br /> &lt;p style=&quot;margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;&quot;&gt;<br /> [2] &lt;strong&gt;Hsieh CS, et al. (1993).&lt;/strong&gt; &lt;em&gt;Development of Th1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages.&lt;/em&gt; &lt;strong&gt;[[Science]]&lt;/strong&gt;. &lt;br&gt;<br /> &lt;span style=&quot;color: #475569;&quot;&gt;[核心价值]：明确了 IL-12 是诱导 CD4+ T 细胞向 Th1 亚群分化的关键因子，建立了“抗原提呈细胞-IL12-Th1”的经典免疫调节模型。&lt;/span&gt;<br /> &lt;/p&gt;<br /> <br /> &lt;p style=&quot;margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;&quot;&gt;<br /> [3] &lt;strong&gt;Pegram HJ, et al. (2012).&lt;/strong&gt; &lt;em&gt;Tumor-targeted T cells modified to secrete IL-12 eradicate systemic tumors without need for prior conditioning.&lt;/em&gt; &lt;strong&gt;[[Blood]]&lt;/strong&gt;. &lt;br&gt;<br /> &lt;span style=&quot;color: #475569;&quot;&gt;[前沿应用]：证明了分泌 IL-12 的 CAR-T 细胞（Armored CAR-T）能够通过重塑肿瘤微环境，清除抗原阴性的肿瘤细胞。&lt;/span&gt;<br /> &lt;/p&gt;<br /> &lt;/div&gt;<br /> <br /> &lt;div style=&quot;margin: 40px 0; border: 1px solid #e2e8f0; border-radius: 8px; overflow: hidden; font-family: 'Helvetica Neue', Arial, sans-serif; font-size: 0.9em;&quot;&gt;<br /> &lt;div style=&quot;background-color: #eff6ff; color: #1e40af; padding: 8px 15px; font-weight: bold; text-align: center; border-bottom: 1px solid #dbeafe;&quot;&gt;<br /> [[IL-12]] (p70) 免疫调控生态 · 知识图谱<br /> &lt;/div&gt;<br /> &lt;table style=&quot;width: 100%; border-collapse: collapse; background-color: #ffffff;&quot;&gt;<br /> &lt;tr style=&quot;border-bottom: 1px solid #f1f5f9;&quot;&gt;<br /> &lt;td style=&quot;width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;&quot;&gt;关联分子&lt;/td&gt;<br /> &lt;td style=&quot;padding: 10px 15px; color: #334155;&quot;&gt;[[IL-23]]•[[p40亚基]]•[[STAT4]]•[[IFN-γ]]•[[IL-12Rβ1]]&lt;/td&gt;<br /> &lt;/tr&gt;<br /> &lt;tr style=&quot;border-bottom: 1px solid #f1f5f9;&quot;&gt;<br /> &lt;td style=&quot;width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;&quot;&gt;药物靶向&lt;/td&gt;<br /> &lt;td style=&quot;padding: 10px 15px; color: #334155;&quot;&gt;[[乌司奴单抗]] (Stelara)•[[Briakinumab]]•[[TAVO]] (Tavokinogene)&lt;/td&gt;<br /> &lt;/tr&gt;<br /> &lt;tr style=&quot;border-bottom: 1px solid #f1f5f9;&quot;&gt;<br /> &lt;td style=&quot;width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;&quot;&gt;临床病理&lt;/td&gt;<br /> &lt;td style=&quot;padding: 10px 15px; color: #334155;&quot;&gt;[[银屑病]]•[[克罗恩病]]•[[MSMD]] (孟德尔遗传易感性)•[[肿瘤微环境]]&lt;/td&gt;<br /> &lt;/tr&gt;<br /> &lt;tr&gt;<br /> &lt;td style=&quot;width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;&quot;&gt;前沿技术&lt;/td&gt;<br /> &lt;td style=&quot;padding: 10px 15px; color: #334155;&quot;&gt;[[装甲型CAR-T]] (TRUCKs)•[[瘤内注射]]•[[mRNA疗法]]•[[免疫细胞因子]]&lt;/td&gt;<br /> &lt;/tr&gt;<br /> &lt;/table&gt;<br /> &lt;/div&gt;<br /> <br /> &lt;/div&gt;</div>

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