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NKT细胞 - 版本历史
2026-04-18T11:46:19Z
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2026年1月27日 (二) 11:43 77921020
2026-01-27T11:43:13Z
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2026年1月27日 (二) 11:28 77921020
2026-01-27T11:28:51Z
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2025年12月28日 (日) 14:02 77921020
2025-12-28T14:02:16Z
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<table class="diff diff-contentalign-left diff-editfont-monospace" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2025年12月28日 (日) 14:02的版本</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l3" >第3行：</td>
<td colspan="2" class="diff-lineno">第3行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><div style="margin-bottom: 25px; border-bottom: 1.2px solid #e2e8f0; padding-bottom: 20px;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><div style="margin-bottom: 25px; border-bottom: 1.2px solid #e2e8f0; padding-bottom: 20px;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="font-size: 1.15em; margin: 10px 0; color: #0f172a; font-weight: 500;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="font-size: 1.15em; margin: 10px 0; color: #0f172a; font-weight: 500;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <strong>NKT细胞</strong>（Natural Killer T Cell）系一类兼具 T 淋巴细胞（表达 [[TCR]]）与 NK 细胞（表达 CD56/CD161）表面标志物的独特免疫细胞亚群。其核心特征在于识别由非多态性 **[[CD1d]]** 分子呈递的脂质或糖脂抗原。作为免疫系统的“极化中枢”，NKT <del class="diffchange diffchange-inline">细胞在抗肿瘤免疫、调节</del>[[肿瘤微环境]]及募集多种免疫效应细胞中发挥着不可替代的作用。</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <strong>NKT细胞</strong>（Natural Killer T Cell）系一类兼具 T 淋巴细胞（表达 [[TCR]]）与 NK 细胞（表达 CD56/CD161）表面标志物的独特免疫细胞亚群。其核心特征在于识别由非多态性 **[[CD1d]]** 分子呈递的脂质或糖脂抗原。作为免疫系统的“极化中枢”，NKT <ins class="diffchange diffchange-inline">细胞在抗肿瘤免疫、重塑</ins>[[肿瘤微环境]]及募集多种免疫效应细胞中发挥着不可替代的作用。</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></div></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l9" >第9行：</td>
<td colspan="2" class="diff-lineno">第9行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><div class="medical-infobox mw-collapsible mw-collapsed" style="float: right; width: 320px; margin: 0 0 25px 25px; border: 1.5px solid #94a3b8; border-radius: 12px; background-color: #ffffff; box-shadow: 0 10px 25px rgba(0,0,0,0.08); overflow: hidden;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><div class="medical-infobox mw-collapsible mw-collapsed" style="float: right; width: 320px; margin: 0 0 25px 25px; border: 1.5px solid #94a3b8; border-radius: 12px; background-color: #ffffff; box-shadow: 0 10px 25px rgba(0,0,0,0.08); overflow: hidden;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="padding: 18px 15px; color: #ffffff; background: linear-gradient(135deg, #0f172a 0%, #1e40af 100%); text-align: center; cursor: pointer; text-decoration: none;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="padding: 18px 15px; color: #ffffff; background: linear-gradient(135deg, #0f172a 0%, #1e40af 100%); text-align: center; cursor: pointer; text-decoration<ins class="diffchange diffchange-inline">: none; border-bottom</ins>: none;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="font-size: 1.25em; font-weight: bold; letter-spacing: 1.5px; text-decoration: none;">NKT细胞 · 生物图谱</div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="font-size: 1.25em; font-weight: bold; letter-spacing: 1.5px; text-decoration: none;">NKT细胞 · 生物图谱</div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="font-size: 0.75em; opacity: 0.9; margin-top: 5px; white-space: nowrap; text-decoration: none;">Cellular Profile (点击展开)</div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="font-size: 0.75em; opacity: 0.9; margin-top: 5px; white-space: nowrap; text-decoration: none;">Cellular Profile (点击展开)</div></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l17" >第17行：</td>
<td colspan="2" class="diff-lineno">第17行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="padding: 30px; text-align: center; background-color: #f8fafc;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="padding: 30px; text-align: center; background-color: #f8fafc;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="display: inline-block; background: #ffffff; border: 1px solid #cbd5e1; border-radius: 8px; padding: 25px; box-shadow: 0 4px 6px rgba(0,0,0,0.05);"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="display: inline-block; background: #ffffff; border: 1px solid #cbd5e1; border-radius: 8px; padding: 25px; box-shadow: 0 4px 6px rgba(0,0,0,0.05);"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <del class="diffchange diffchange-inline">[[文件:NKT_Cell_CD1d_Recognition.png|200px|NKT识别机制]]</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="font-size: 0.85em; color: #475569; margin-top: 15px; font-weight: 600;">TCR 与 CD1d 之脂质抗原识别</div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="font-size: 0.85em; color: #475569; margin-top: 15px; font-weight: 600;">TCR 与 CD1d 之脂质抗原识别</div></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l39" >第39行：</td>
<td colspan="2" class="diff-lineno">第39行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><h2 style="background: linear-gradient(to right, #0f172a, #3b82f6); color: #ffffff; padding: 10px 18px; border-radius: 4px; font-size: 1.25em; margin-top: 35px; border-left: 6px solid #1e3a8a; text-decoration: none;">生物学机制：脂质抗原的非经典识别</h2></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><h2 style="background: linear-gradient(to right, #0f172a, #3b82f6); color: #ffffff; padding: 10px 18px; border-radius: 4px; font-size: 1.25em; margin-top: 35px; border-left: 6px solid #1e3a8a<ins class="diffchange diffchange-inline">; border-bottom: none</ins>; text-decoration: none;">生物学机制：脂质抗原的非经典识别</h2></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">[Image comparing T cell, NK cell and NKT cell receptors]</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p style="margin: 15px 0;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p style="margin: 15px 0;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> NKT 细胞通过其高度保守的 [[TCR]] 链，实现对 CD1d 分子呈递抗原的精准扫描。与传统 T 细胞识别蛋白质肽段不同，NKT 识别的是由 [[CD1d]] 分子（一种非多态性类 MHC-I 分子）提呈的[[糖脂]]。这种机制赋予了 NKT <del class="diffchange diffchange-inline">细胞识别肿瘤脂质代谢异常的独特能力。</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> NKT 细胞通过其高度保守的 [[TCR]] 链，实现对 CD1d 分子呈递抗原的精准扫描。与传统 T 细胞识别蛋白质肽段不同，NKT 识别的是由 [[CD1d]] 分子（一种非多态性类 MHC-I 分子）提呈的[[糖脂]]。这种机制赋予了 NKT <ins class="diffchange diffchange-inline">细胞识别肿瘤脂质代谢异常的独特能力。激活后的 NKT 细胞能迅速分泌大量 $IFN-\gamma$ 和 $IL-4$，作为“免疫开关”动员全身免疫应答。</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></p></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><h2 style="background: linear-gradient(to right, #0f172a, #3b82f6); color: #ffffff; padding: 10px 18px; border-radius: 4px; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #1e3a8a; text-decoration: none;">细胞类型横向对比</h2></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><h2 style="background: linear-gradient(to right, #0f172a, #3b82f6); color: #ffffff; padding: 10px 18px; border-radius: 4px; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #1e3a8a<ins class="diffchange diffchange-inline">; border-bottom: none</ins>; text-decoration: none;">细胞类型横向对比</h2></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><div style="overflow-x: auto; margin: 30px 0;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><div style="overflow-x: auto; margin: 30px 0;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <table style="width: 85%; max-width: 600px; border-collapse: collapse; border: 1px solid #cbd5e1; font-size: 0.95em; text-align: left;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <table style="width: 85%; max-width: 600px; border-collapse: collapse; border: 1px solid #cbd5e1; font-size: 0.95em; text-align: left;"></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l64" >第64行：</td>
<td colspan="2" class="diff-lineno">第64行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: bold;"><del class="diffchange diffchange-inline">免疫应答</del></td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: bold;"><ins class="diffchange diffchange-inline">应答速度</ins></td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1;"><del class="diffchange diffchange-inline">一线杀伤</del></td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1;"><ins class="diffchange diffchange-inline">即时</ins></td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; color: #1e40af; font-weight: bold;"><del class="diffchange diffchange-inline">调节 + 杀伤</del></td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; color: #1e40af; font-weight: bold;"><ins class="diffchange diffchange-inline">极快（数小时）</ins></td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </table></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </table></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><h2 style="background: linear-gradient(to right, #0f172a, #3b82f6); color: #ffffff; padding: 10px 18px; border-radius: 4px; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #1e3a8a; text-decoration: none;">参考文献</h2></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><h2 style="background: linear-gradient(to right, #0f172a, #3b82f6); color: #ffffff; padding: 10px 18px; border-radius: 4px; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #1e3a8a<ins class="diffchange diffchange-inline">; border-bottom: none</ins>; text-decoration: none;">参考文献</h2></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><div style="font-size: 0.9em; line-height: 1.6; color: #1e293b; margin-top: 15px; background-color: #f8fafc; padding: 20px; border-radius: 8px; border-top: 3px solid #0f172a;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><div style="font-size: 0.9em; line-height: 1.6; color: #1e293b; margin-top: 15px; background-color: #f8fafc; padding: 20px; border-radius: 8px; border-top: 3px solid #0f172a;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="margin: 10px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="margin: 10px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> [1] <strong>Godfrey D I, et al. (2018).</strong> <em>The biology and functional diversity of NKT cells.</em> <strong>Nature Reviews Immunology</strong>. <br></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> [1] <strong>Godfrey D I, et al. (2018).</strong> <em>The biology and functional diversity of NKT cells.</em> <strong>Nature Reviews Immunology</strong>. <br></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <span style="color: #1e40af; font-weight: 500;">[学术点评]<del class="diffchange diffchange-inline">：该领域最具影响力的综述之一，系统界定了 </del>iNKT <del class="diffchange diffchange-inline">在肿瘤免疫监视与平衡中的多面性。</del></span></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <span style="color: #1e40af; font-weight: 500;">[学术点评]<ins class="diffchange diffchange-inline">：该领域最具权威性的综述之一，系统界定了 </ins>iNKT <ins class="diffchange diffchange-inline">在肿瘤免疫监视中的核心枢纽地位。</ins></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="margin: 10px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="margin: 10px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> [2] <strong><del class="diffchange diffchange-inline">Brennan P J</del>, et al. (<del class="diffchange diffchange-inline">2013</del>).</strong> <em><del class="diffchange diffchange-inline">Invariant natural killer T </del>cells<del class="diffchange diffchange-inline">: an innate activation scheme based on self-lipid recognition</del>.</em> <strong>Nature <del class="diffchange diffchange-inline">Reviews Immunology</del></strong>. <br></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> [2] <strong><ins class="diffchange diffchange-inline">Heczey A</ins>, et al. (<ins class="diffchange diffchange-inline">2020</ins>).</strong> <em><ins class="diffchange diffchange-inline">Anti-GD2 CAR-NKT </ins>cells <ins class="diffchange diffchange-inline">in patients with relapsed or refractory neuroblastoma</ins>.</em> <strong>Nature <ins class="diffchange diffchange-inline">Medicine</ins></strong>. <br></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <span style="color: #1e40af; font-weight: 500;">[学术点评]<del class="diffchange diffchange-inline">：详尽阐明了 </del>NKT <del class="diffchange diffchange-inline">细胞通过识别内源性脂质激活免疫反应的机制，为理解自身免疫应答奠定了基础。</del></span></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <span style="color: #1e40af; font-weight: 500;">[学术点评]<ins class="diffchange diffchange-inline">：里程碑式的临床研究，首次证实了工程化 </ins>NKT <ins class="diffchange diffchange-inline">细胞在处理实体瘤及调控抑制性微环境中的安全性。</ins></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="margin: 10px 0;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="margin: 10px 0;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> [3] <strong><del class="diffchange diffchange-inline">Xu X</del>, et al. (<del class="diffchange diffchange-inline">2022</del>).</strong> <em><del class="diffchange diffchange-inline">CAR-NKT </del>cells: <del class="diffchange diffchange-inline">a promising next</del>-<del class="diffchange diffchange-inline">generation of cancer immunotherapy</del>.</em> <strong><del class="diffchange diffchange-inline">Journal of Hematology & Oncology</del></strong>. <br></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> [3] <strong><ins class="diffchange diffchange-inline">Brennan P J</ins>, et al. (<ins class="diffchange diffchange-inline">2013</ins>).</strong> <em><ins class="diffchange diffchange-inline">Invariant natural killer T </ins>cells: <ins class="diffchange diffchange-inline">an innate activation scheme based on self</ins>-<ins class="diffchange diffchange-inline">lipid recognition</ins>.</em> <strong><ins class="diffchange diffchange-inline">Nature Reviews Immunology</ins></strong>. <br></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <span style="color: #1e40af; font-weight: 500;">[学术点评]<del class="diffchange diffchange-inline">：探讨了 </del>NKT <del class="diffchange diffchange-inline">细胞在基因工程修饰后的临床转化潜力，特别是作为通用型 CAR 平台的优势。</del></span></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <span style="color: #1e40af; font-weight: 500;">[学术点评]<ins class="diffchange diffchange-inline">：详述了 </ins>NKT <ins class="diffchange diffchange-inline">识别内源性脂质抗原的分子逻辑，为理解自身免疫应答提供了重要理论支柱。</ins></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><div style="margin: 45px 0; border: 1.5px solid #0f172a; border-radius: 8px; overflow: hidden; font-size: 0.95em;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><div style="margin: 45px 0; border: 1.5px solid #0f172a; border-radius: 8px; overflow: hidden; font-size: 0.95em;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="background-color: #0f172a; color: #ffffff; text-align: center; font-weight: bold; padding: 12px; letter-spacing: 2px; text-decoration: none;"><del class="diffchange diffchange-inline">关联知识导航</del></div></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="background-color: #0f172a; color: #ffffff; text-align: center; font-weight: bold; padding: 12px; letter-spacing: 2px; text-decoration: none;"><ins class="diffchange diffchange-inline">相关知识导航</ins></div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="padding: 20px; background: #ffffff; line-height: 2.2; text-align: center;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="padding: 20px; background: #ffffff; line-height: 2.2; text-align: center;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> [[CD1d限制性识别]] • [[CAR-NKT]] • [[alpha-GalCer]] • [[通用型细胞治疗]] • [[肿瘤浸润淋巴细胞]]</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> [[CD1d限制性识别]] • [[CAR-NKT]] • [[alpha-GalCer]] • [[通用型细胞治疗]] • [[肿瘤浸润淋巴细胞]]</div></td></tr>
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77921020
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2025年12月28日 (日) 14:00 77921020
2025-12-28T14:00:23Z
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77921020：建立内容为“<div style="padding: 0 2%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面
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<p>建立内容为“<div style="padding: 0 2%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面</p>
<p><b>新页面</b></p><div><div style="padding: 0 2%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff;"><br />
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<strong>NKT细胞</strong>（Natural Killer T Cell）系一类兼具 T 淋巴细胞（表达 [[TCR]]）与 NK 细胞（表达 CD56/CD161）表面标志物的独特免疫细胞亚群。其核心特征在于识别由非多态性 **[[CD1d]]** 分子呈递的脂质或糖脂抗原，而非传统的 MHC 限制性肽抗原。作为免疫系统的“轴心调节者”，NKT 细胞在抗肿瘤免疫、自身免疫疾病及感染性疾病的病理生理过程中发挥着关键的跨系统协同作用。<br />
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<div style="font-size: 1.25em; font-weight: bold; letter-spacing: 1.5px;">NKT细胞 · 生物图谱</div><br />
<div style="font-size: 0.75em; opacity: 0.9; margin-top: 5px; white-space: nowrap;">NKT Cell Biological Atlas (点击展开)</div><br />
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<div style="font-size: 0.85em; color: #475569; margin-top: 15px; font-weight: 600;">TCR 与 CD1d-糖脂复合物之交互视阈</div><br />
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<td style="padding: 12px 18px; border-bottom: 1px solid #f1f5f9; color: #0f172a;">$\alpha$-GalCer</td><br />
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NKT 细胞（主要指 I 型不变型 NKT，iNKT）通过其半恒定（Semi-invariant）的 [[TCR]] 链实现对抗原的高效扫描：<br />
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<li style="margin-bottom: 12px;"><strong>CD1d 限制性识别：</strong> 不同于识别 MHC 肽段的传统 T 细胞，NKT 识别的是由非多态性 CD1d 分子提呈的[[糖脂]]抗原。</li><br />
<li style="margin-bottom: 12px;"><strong>爆发式细胞因子分泌：</strong> 激活后能迅速分泌大量 [[IFN-γ]]（Th1 型）及 IL-4（Th2 型），产生瀑布式免疫应答。</li><br />
<li style="margin-bottom: 12px;"><strong>直接细胞毒性：</strong> 通过[[穿孔素]]与[[颗粒酶]]路径，诱导肿瘤细胞凋亡。</li><br />
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<h2 style="background: linear-gradient(to right, #0f172a, #3b82f6); color: #ffffff; padding: 10px 18px; border-radius: 4px; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #1e3a8a;">NKT 细胞与传统免疫细胞对比</h2><br />
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<th style="padding: 12px; border: 1px solid #cbd5e1;">特性</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1;">[[CD8+ T细胞]]</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1;">NKT 细胞</th><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: bold;">识别分子</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">MHC-I</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1; color: #16a34a; font-weight: bold;">CD1d</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: bold;">抗原类型</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: bold;">反应速度</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">数日</td><br />
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<h2 style="background: linear-gradient(to right, #0f172a, #3b82f6); color: #ffffff; padding: 10px 18px; border-radius: 4px; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #1e3a8a;">参考文献</h2><br />
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[1] <strong>Godfrey D I, et al. (2018).</strong> <em>The biology and functional diversity of NKT cells.</em> <strong>Nature Reviews Immunology</strong>. <br><br />
<span style="color: #1e40af; font-weight: 500;">[学术点评]：该综述系统界定了 iNKT 在肿瘤监测中的枢纽作用，是研究先天-适应性免疫交汇点的纲领性文献。</span><br />
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[2] <strong>Brennan P J, et al. (2013).</strong> <em>Invariant natural killer T cells: an innate activation scheme based on self-lipid recognition.</em> <strong>Nature Reviews Immunology</strong>. <br><br />
<span style="color: #1e40af; font-weight: 500;">[学术点评]：详述了 NKT 细胞识别内源性脂质抗原的分子机制，阐明了其在维持机体稳态中的基础地位。</span><br />
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[3] <strong>Van Kaer L, et al. (2013).</strong> <em>NKT cells as targets for immunotherapy.</em> <strong>Expert Opinion on Therapeutic Targets</strong>. <br><br />
<span style="color: #1e40af; font-weight: 500;">[学术点评]：深入探讨了利用脂质配体激活 NKT 以调节全局免疫应答的转化医学策略，为后续 CAR-NKT 研发提供了理论支持。</span><br />
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<div style="background-color: #0f172a; color: #ffffff; text-align: center; font-weight: bold; padding: 12px; letter-spacing: 2px;">相关知识导航</div><br />
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[[CD1d限制性识别]] • [[CAR-NKT]] • [[alpha-GalCer]] • [[通用型细胞治疗]] • [[肿瘤浸润淋巴细胞]]<br />
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