https://www.yiliao.com/index.php?action=history&feed=atom&title=Molecular_Cell
Molecular Cell - 版本历史
2026-04-18T11:00:34Z
本wiki的该页面的版本历史
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https://www.yiliao.com/index.php?title=Molecular_Cell&diff=312541&oldid=prev
2026年1月3日 (六) 16:03 77921020
2026-01-03T16:03:20Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2026年1月3日 (六) 16:03的版本</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l33" >第33行：</td>
<td colspan="2" class="diff-lineno">第33行：</td></tr>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">影响因子</th></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">影响因子</th></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #b91c1c; font-weight: bold;"><del class="diffchange diffchange-inline">16</del>.0 (2023 JCR)</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #b91c1c; font-weight: bold;"><ins class="diffchange diffchange-inline">14</ins>.0 (2023 JCR)</td></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l64" >第64行：</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 25%;">期刊</th></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 25%;">期刊</th></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569;">出版商</th></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569;">出版商</th></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af;"><del class="diffchange diffchange-inline">侧重点</del></th></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af;"><ins class="diffchange diffchange-inline">IF (2023)</ins></th></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a;"><del class="diffchange diffchange-inline">核心气质</del></th></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a;"><ins class="diffchange diffchange-inline">核心气质与差异</ins></th></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #ffffff;">[[Molecular Cell]]</td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #ffffff;">[[Molecular Cell]]</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 8px; border: 1px solid #cbd5e1;">Cell Press</td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 8px; border: 1px solid #cbd5e1;">Cell Press</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 8px; border: 1px solid #cbd5e1;"><del class="diffchange diffchange-inline"><strong>功能性机制。</strong> 强调生化功能与细胞生理的结合。</del></td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 8px; border: 1px solid #cbd5e1<ins class="diffchange diffchange-inline">; color: #b91c1c; font-weight:bold</ins>;"><ins class="diffchange diffchange-inline">14.0</ins></td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 8px; border: 1px solid #cbd5e1;"><strong><del class="diffchange diffchange-inline">“动态”。</del></strong> <del class="diffchange diffchange-inline">关注酶的动力学、蛋白质复合物的动态组装。是 </del><strong>[[RNA剪接]]</strong> 和 <strong>[[DNA损伤修复]]</strong> 领域的首选。</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 8px; border: 1px solid #cbd5e1;"><strong><ins class="diffchange diffchange-inline">“动态机制”。</ins></strong> <ins class="diffchange diffchange-inline">强调生化功能。关注酶的动力学、蛋白质复合物的动态组装。是 </ins><strong>[[RNA剪接]]</strong> 和 <strong>[[DNA损伤修复]]</strong> 领域的首选。</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #f8fafc;">[[Nature Structural & Molecular Biology]]</td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #f8fafc;">[[Nature Structural & Molecular Biology]]</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 8px; border: 1px solid #cbd5e1;">Nature Portfolio</td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 8px; border: 1px solid #cbd5e1;">Nature Portfolio</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 8px; border: 1px solid #cbd5e1;"><del class="diffchange diffchange-inline"><strong>结构细节。</strong> 强调原子分辨率的结构解析。</del></td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 8px; border: 1px solid #cbd5e1<ins class="diffchange diffchange-inline">; color: #b91c1c; font-weight:bold</ins>;"><ins class="diffchange diffchange-inline">12.5</ins></td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 8px; border: 1px solid #cbd5e1;"><strong><del class="diffchange diffchange-inline">“静态”。</del></strong> <del class="diffchange diffchange-inline">历史上更偏向 </del><strong>[[X射线晶体学]]</strong> 和 <strong>[[冷冻电镜]]</strong> (Cryo-EM) 的技术突破，对纯结构文章更友好。</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 8px; border: 1px solid #cbd5e1;"><strong><ins class="diffchange diffchange-inline">“静态结构”。</ins></strong> <ins class="diffchange diffchange-inline">强调原子分辨率。历史上更偏向 </ins><strong>[[X射线晶体学]]</strong> 和 <strong>[[冷冻电镜]]</strong> (Cryo-EM) 的技术突破，对纯结构文章更友好。</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #ffffff;">[[Genes & Development]]</td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #ffffff;">[[Genes & Development]]</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 8px; border: 1px solid #cbd5e1;">CSHL Press</td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 8px; border: 1px solid #cbd5e1;">CSHL Press</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 8px; border: 1px solid #cbd5e1;"><del class="diffchange diffchange-inline"><strong>遗传学途径。</strong> 强调体内遗传学证据。</del></td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 8px; border: 1px solid #cbd5e1<ins class="diffchange diffchange-inline">; color: #64748b</ins>;"><ins class="diffchange diffchange-inline">7.5</ins></td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 8px; border: 1px solid #cbd5e1;"><strong><del class="diffchange diffchange-inline">“经典”。</del></strong> <del class="diffchange diffchange-inline">冷泉港出版。历史上是转录调控的圣地，风格较为传统稳重，近年来IF有所下滑但口碑极佳。</del></td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 8px; border: 1px solid #cbd5e1;"><strong><ins class="diffchange diffchange-inline">“遗传经典”。</ins></strong> <ins class="diffchange diffchange-inline">冷泉港出版。历史上是转录调控的圣地，强调体内遗传学证据。风格稳重，近年来 IF 有所下滑但学术口碑极佳。</ins></td></div></td></tr>
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2026-01-03T16:00:22Z
<p>建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面</p>
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<strong>Molecular Cell</strong> 是 <strong>[[Cell Press]]</strong>（细胞出版社）旗下的顶级月刊，创刊于 1997 年。作为分子生物学领域的旗舰期刊，它专注于从<strong>原子</strong>和<strong>分子</strong>水平解析细胞功能。与侧重于细胞行为和命运的 <strong>[[Nature Cell Biology]]</strong> 不同，Molecular Cell 更偏好“硬核”的 <strong>[[生物化学]]</strong>（Biochemistry）和 <strong>[[结构生物学]]</strong>（Structural Biology）。它是 <strong>[[中心法则]]</strong>（DNA复制、转录、翻译）以及基因表达调控、RNA 加工和 DNA 修复领域最权威的研究阵地。<br />
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<div style="font-size: 1.2em; font-weight: bold; letter-spacing: 1.2px;">Molecular Cell</div><br />
<div style="font-size: 0.7em; opacity: 0.85; margin-top: 4px; white-space: nowrap;">Mol. Cell (点击展开)</div><br />
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[[Image:Molecular_Cell_Logo.png|100px|Molecular Cell 封面标识]]<br />
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<div style="font-size: 0.8em; color: #64748b; margin-top: 12px; font-weight: 600;">分子机制的终极解析</div><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; width: 40%;">创刊年份</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">1997年</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">出版机构</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;">[[Cell Press]]</td><br />
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<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #b91c1c; font-weight: bold;">16.0 (2023 JCR)</td><br />
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<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">体外重组, 结构解析</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569;">核心标签</th><br />
<td style="padding: 6px 12px; color: #1e40af;">[[RNA生物学]], [[染色质]]</td><br />
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如果说 <strong>[[Cell]]</strong> 关注的是整个生物学故事，那么 Molecular Cell 关注的就是故事背后的“语法规则”。它极度推崇通过<strong>体外重组</strong>（In vitro reconstitution）实验来证明因果关系，要求作者精确描述蛋白质机器（Protein Machines）是如何组装、催化和解离的。在这里，仅仅敲除一个基因并观察表型往往是不够的，你必须解释清楚该基因产物具体的生化活性。<br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">横向测评：分子生物学顶刊</h2><br />
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在分子与结构生物学领域，Molecular Cell 与 Nature 旗下的 NSMB 形成了直接竞争。<br />
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<th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 25%;">期刊</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569;">出版商</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af;">侧重点</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a;">核心气质</th><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #ffffff;">[[Molecular Cell]]</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;">Cell Press</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;"><strong>功能性机制。</strong> 强调生化功能与细胞生理的结合。</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;"><strong>“动态”。</strong> 关注酶的动力学、蛋白质复合物的动态组装。是 <strong>[[RNA剪接]]</strong> 和 <strong>[[DNA损伤修复]]</strong> 领域的首选。</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #f8fafc;">[[Nature Structural & Molecular Biology]]</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;">Nature Portfolio</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;"><strong>结构细节。</strong> 强调原子分辨率的结构解析。</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;"><strong>“静态”。</strong> 历史上更偏向 <strong>[[X射线晶体学]]</strong> 和 <strong>[[冷冻电镜]]</strong> (Cryo-EM) 的技术突破，对纯结构文章更友好。</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #ffffff;">[[Genes & Development]]</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;">CSHL Press</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;"><strong>遗传学途径。</strong> 强调体内遗传学证据。</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;"><strong>“经典”。</strong> 冷泉港出版。历史上是转录调控的圣地，风格较为传统稳重，近年来IF有所下滑但口碑极佳。</td><br />
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Molecular Cell 非常鼓励发表能推动社区发展的资源，例如高通量的 <strong>[[蛋白质相互作用组]]</strong> 数据、全基因组的 <strong>[[CRISPR筛选]]</strong> 数据集或新型生化工具箱。这类文章通常具有极高的引用率。<br />
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<span style="color: #0f172a; font-weight: bold; font-size: 1.05em; display: inline-block; margin-bottom: 15px;">关键参考文献</span><br />
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[1] <strong>Doudna JA, Charpentier E. (2014).</strong> <em>The new frontier of genome engineering with CRISPR-Cas9.</em> <strong>[[Science]]</strong> (Review).<br><br />
<span style="color: #475569;">[领域关联]：虽然综述发在Science，但大量关于 <strong>[[Cas9]]</strong> 酶学机制、结构构象变化和脱靶机制的原始论文发表在 Molecular Cell 上。</span><br />
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[2] <strong>Heintzman ND, et al. (2007).</strong> <em>Distinct and predictive chromatin signatures...</em> <strong>[[Nat Genet]]</strong> (Comparison).<br><br />
<span style="color: #475569;">[表观遗传]：Molecular Cell 是 <strong>[[组蛋白修饰]]</strong> 和 <strong>[[染色质重塑]]</strong> 研究的核心阵地，发表了大量关于“组蛋白密码”如何被读写器（Readers/Writers）识别的机制研究。</span><br />
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Molecular Cell · 知识图谱<br />
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<td style="padding: 10px 15px; color: #334155;">[[Cell Press]] (Elsevier)</td><br />
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<td style="padding: 10px 15px; color: #334155;">[[基因表达]] • [[DNA修复]] • [[非编码RNA]] • [[蛋白稳态]]</td><br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">竞争对手</td><br />
<td style="padding: 10px 15px; color: #334155;">[[NSMB]] • [[EMBO Journal]] • [[Genes & Development]]</td><br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">方法学</td><br />
<td style="padding: 10px 15px; color: #334155;">[[Cryo-EM]] • [[ChIP-seq]] • [[质谱]] (Mass Spec)</td><br />
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