https://www.yiliao.com/index.php?action=history&feed=atom&title=II%E7%9B%B8%E4%BB%A3%E8%B0%A2
II相代谢 - 版本历史
2026-04-21T16:37:18Z
本wiki的该页面的版本历史
MediaWiki 1.35.1
https://www.yiliao.com/index.php?title=II%E7%9B%B8%E4%BB%A3%E8%B0%A2&diff=315621&oldid=prev
2026年1月25日 (日) 00:49 77921020
2026-01-25T00:49:04Z
<p></p>
<table class="diff diff-contentalign-left diff-editfont-monospace" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="zh-Hans-CN">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2026年1月25日 (日) 00:49的版本</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l114" >第114行：</td>
<td colspan="2" class="diff-lineno">第114行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"> [[Image:Enterohepatic_circulation_diagram.png|100px|肠肝循环示意图]]</del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <ul style="padding-left: 25px; color: #334155;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <ul style="padding-left: 25px; color: #334155;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 12px;"><strong>细菌水解：</strong> 肠道菌群分泌的 <strong><del class="diffchange diffchange-inline">$\beta$</del>-葡萄糖醛酸酶</strong> <del class="diffchange diffchange-inline">可以将结合物“拆解”，释放出脂溶性的原药。</del></li></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 12px;"><strong>细菌水解：</strong> 肠道菌群分泌的 <strong><ins class="diffchange diffchange-inline">β</ins>-葡萄糖醛酸酶</strong><ins class="diffchange diffchange-inline">（Beta-glucuronidase）可以将结合物“拆解”，释放出脂溶性的原药。</ins></li></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 12px;"><strong>重吸收：</strong> 释放出的原药再次被肠壁吸收进入血液，回到肝脏。</li></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 12px;"><strong>重吸收：</strong> 释放出的原药再次被肠壁吸收进入血液，回到肝脏。</li></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 12px;"><strong>临床影响：</strong> 延长了药物的半衰期（如麦考酚酯、伊立替康），但也可能导致肠道毒性（如 SN-38 在肠道蓄积导致迟发性腹泻）。</li></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 12px;"><strong>临床影响：</strong> 延长了药物的半衰期（如麦考酚酯、伊立替康），但也可能导致肠道毒性（如 SN-38 在肠道蓄积导致迟发性腹泻）。</li></div></td></tr>
</table>
77921020
https://www.yiliao.com/index.php?title=II%E7%9B%B8%E4%BB%A3%E8%B0%A2&diff=315620&oldid=prev
77921020：建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面
2026-01-25T00:46:49Z
<p>建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面</p>
<p><b>新页面</b></p><div><div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff; max-width: 1200px; margin: auto;"><br />
<br />
<div style="margin-bottom: 30px; border-bottom: 1.2px solid #e2e8f0; padding-bottom: 25px;"><br />
<p style="font-size: 1.1em; margin: 10px 0; color: #334155; text-align: justify;"><br />
<strong>II 相代谢</strong>（Phase II Metabolism），又称<strong>结合反应</strong>（Conjugation Reaction），是药物生物转化的最后一道工序（通常继 I 相代谢之后，也可直接发生）。在此过程中，药物原形或其 I 相代谢产物与内源性小分子（如葡萄糖醛酸、硫酸、谷胱甘肽、乙酸等）在转移酶的催化下发生共价结合。这一反应的最终目的是通过大幅增加药物分子的<strong>极性</strong>和<strong>水溶性</strong>，使其无法再穿过生物膜被重吸收，从而通过肾脏（尿液）或胆汁（粪便）被强制排出体外。临床上，II 相代谢酶的基因多态性（如 <strong>[[UGT1A1]]</strong>）常导致严重的药物毒性（如伊立替康腹泻）。<br />
</p><br />
</div><br />
<br />
<div class="medical-infobox mw-collapsible mw-collapsed" style="width: 100%; max-width: 320px; margin: 0 auto 35px auto; border: 1.2px solid #bae6fd; border-radius: 12px; background-color: #ffffff; box-shadow: 0 8px 20px rgba(0,0,0,0.05); overflow: hidden;"><br />
<br />
<div style="padding: 15px; color: #1e40af; background: linear-gradient(135deg, #e0f2fe 0%, #bae6fd 100%); text-align: center; cursor: pointer;"><br />
<div style="font-size: 1.2em; font-weight: bold; letter-spacing: 1.2px;">Phase II Metabolism</div><br />
<div style="font-size: 0.7em; opacity: 0.85; margin-top: 4px; white-space: nowrap;">Conjugation / Synthetic (点击展开)</div><br />
</div><br />
<br />
<div class="mw-collapsible-content"><br />
<div style="padding: 25px; text-align: center; background-color: #f8fafc;"><br />
<div style="display: inline-block; background: #ffffff; border: 1px solid #e2e8f0; border-radius: 12px; padding: 20px; box-shadow: 0 4px 10px rgba(0,0,0,0.04);"><br />
[[Image:Phase_II_conjugation_reaction_diagram.png|100px|II 相结合反应示意图]]<br />
</div><br />
<div style="font-size: 0.8em; color: #64748b; margin-top: 12px; font-weight: 600;">大分子结合 • 彻底排泄</div><br />
</div><br />
<br />
<table style="width: 100%; border-spacing: 0; border-collapse: collapse; font-size: 0.85em;"><br />
<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; width: 40%;">别称</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">合成反应 (Synthetic)</td><br />
</tr><br />
<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">主要场所</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;"><strong>胞质溶胶</strong> (大多数)<br>微粒体 (仅 UGTs)</td><br />
</tr><br />
<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">核心酶系</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #b91c1c;"><strong>[[UGT]]</strong> (最主要)<br>SULT, GST, NAT</td><br />
</tr><br />
<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">反应结果</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">分子量剧增, 极性剧增</td><br />
</tr><br />
<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">药理活性</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #166534;">通常<strong>完全失活</strong><br>(除吗啡-6-葡糖醛酸苷等)</td><br />
</tr><br />
<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">辅因子</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">UDPGA, PAPS, 谷胱甘肽</td><br />
</tr><br />
<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569;">相关疾病</th><br />
<td style="padding: 6px 12px; color: #0f172a;">灰婴综合征 (UGT缺乏)<br>吉尔伯特综合征</td><br />
</tr><br />
</table><br />
</div><br />
</div><br />
<br />
<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">四大核心反应类型</h2><br />
<br />
<p style="margin: 15px 0; text-align: justify;"><br />
与 I 相代谢（CYP450 独大）不同，II 相代谢由多种酶系共同完成。<br />
</p><br />
<br />
<div style="overflow-x: auto; margin: 30px auto; max-width: 95%;"><br />
<table style="width: 100%; border-collapse: collapse; border: 1.2px solid #cbd5e1; font-size: 0.95em; text-align: left;"><br />
<tr style="background-color: #f8fafc; border-bottom: 2px solid #0f172a;"><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 15%;">反应类型</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af; width: 20%;">关键酶系</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569; width: 65%;">机制与临床案例</th><br />
</tr><br />
<tr><br />
<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;"><strong>葡萄糖醛酸结合</strong></td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;"><strong>[[UGT]]</strong></td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;"><br />
<strong>最重要</strong>（占 II 相反应的 40%-70%）。<br><br />
• <strong>机制：</strong> 将葡萄糖醛酸转移到药物上。<br><br />
• <strong>案例：</strong> 胆红素、<strong>[[伊立替康]]</strong> (SN-38)、氯霉素。<br><br />
• <strong>新生儿：</strong> 酶发育不全导致“灰婴综合征”。<br />
</td><br />
</tr><br />
<tr><br />
<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">硫酸结合</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">SULT</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;"><br />
主要处理酚类、醇类药物及激素。<br><br />
• <strong>特点：</strong> 亲和力高但容量低（辅因子 PAPS 易耗尽）。<br><br />
• <strong>案例：</strong> 对乙酰氨基酚（部分）、类固醇激素。<br />
</td><br />
</tr><br />
<tr><br />
<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;"><strong>乙酰化</strong></td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">NAT</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;"><br />
<strong>遗传多态性极强</strong>。<br><br />
• <strong>快代谢者：</strong> 易发生肝毒性。<br><br />
• <strong>慢代谢者：</strong> 易发生神经毒性（如<strong>[[异烟肼]]</strong>）。<br />
</td><br />
</tr><br />
<tr><br />
<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; color: #b91c1c;">谷胱甘肽结合</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;"><strong>[[GST]]</strong></td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;"><br />
<strong>终极解毒机制</strong>。清除亲电性毒物。<br><br />
• <strong>案例：</strong> 结合对乙酰氨基酚的毒性代谢物 NAPQI。若谷胱甘肽耗尽，则发生肝坏死。<br />
</td><br />
</tr><br />
</table><br />
</div><br />
<br />
<h2 style="background: #fff1f2; color: #9f1239; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #9f1239; font-weight: bold;">特殊机制：肠肝循环</h2><br />
<div style="background-color: #fff5f5; border-left: 5px solid #e11d48; padding: 15px 20px; margin: 20px 0; border-radius: 4px;"><br />
<h3 style="margin-top: 0; color: #be123c; font-size: 1.1em;">排出去又回来的“回旋镖”</h3><br />
<p style="margin-bottom: 0; text-align: justify; font-size: 0.95em; color: #334155;"><br />
经 II 相代谢生成的葡萄糖醛酸结合物（Glucuronides）通过胆汁排入肠道后，并不总是直接排出体外。<br />
</p><br />
</div><br />
[[Image:Enterohepatic_circulation_diagram.png|100px|肠肝循环示意图]]<br />
<br />
<ul style="padding-left: 25px; color: #334155;"><br />
<li style="margin-bottom: 12px;"><strong>细菌水解：</strong> 肠道菌群分泌的 <strong>$\beta$-葡萄糖醛酸酶</strong> 可以将结合物“拆解”，释放出脂溶性的原药。</li><br />
<li style="margin-bottom: 12px;"><strong>重吸收：</strong> 释放出的原药再次被肠壁吸收进入血液，回到肝脏。</li><br />
<li style="margin-bottom: 12px;"><strong>临床影响：</strong> 延长了药物的半衰期（如麦考酚酯、伊立替康），但也可能导致肠道毒性（如 SN-38 在肠道蓄积导致迟发性腹泻）。</li><br />
</ul><br />
<br />
<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">与 I 相代谢的对比</h2><br />
<br />
<table style="width: 100%; border-collapse: collapse; border: 1.2px solid #cbd5e1; font-size: 0.95em; text-align: left; margin-top: 15px;"><br />
<tr style="background-color: #f8fafc; border-bottom: 2px solid #0f172a;"><br />
<th style="padding: 10px; width: 20%;">特征</th><br />
<th style="padding: 10px; width: 40%;">I 相代谢 (Phase I)</th><br />
<th style="padding: 10px; width: 40%;">II 相代谢 (Phase II)</th><br />
</tr><br />
<tr><br />
<td style="padding: 10px; border-bottom: 1px solid #e2e8f0; font-weight: bold;">本质</td><br />
<td style="padding: 10px; border-bottom: 1px solid #e2e8f0;">官能团化 (暴露基团)</td><br />
<td style="padding: 10px; border-bottom: 1px solid #e2e8f0;">合成/结合 (连接大分子)</td><br />
</tr><br />
<tr><br />
<td style="padding: 10px; border-bottom: 1px solid #e2e8f0; font-weight: bold;">分子量变化</td><br />
<td style="padding: 10px; border-bottom: 1px solid #e2e8f0;">微小变化</td><br />
<td style="padding: 10px; border-bottom: 1px solid #e2e8f0;"><strong>显著增加</strong></td><br />
</tr><br />
<tr><br />
<td style="padding: 10px; border-bottom: 1px solid #e2e8f0; font-weight: bold;">产物活性</td><br />
<td style="padding: 10px; border-bottom: 1px solid #e2e8f0;">可能保留或增强</td><br />
<td style="padding: 10px; border-bottom: 1px solid #e2e8f0;">通常完全失活 (易排泄)</td><br />
</tr><br />
<tr><br />
<td style="padding: 10px; font-weight: bold;">主要酶</td><br />
<td style="padding: 10px;">CYP450</td><br />
<td style="padding: 10px;">转移酶 (UGT, GST等)</td><br />
</tr><br />
</table><br />
<br />
<div style="font-size: 0.92em; line-height: 1.6; color: #1e293b; margin-top: 50px; border-top: 2px solid #0f172a; padding: 15px 25px; background-color: #f8fafc; border-radius: 0 0 10px 10px;"><br />
<span style="color: #0f172a; font-weight: bold; font-size: 1.05em; display: inline-block; margin-bottom: 15px;">学术参考文献与权威点评</span><br />
<br />
<p style="margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;"><br />
[1] <strong>Jancova P, et al. (2010).</strong> <em>Phase II drug metabolizing enzymes.</em> <strong>[[Biomedical Papers]]</strong>.<br><br />
<span style="color: #475569;">[综述]：全面总结了 UGT、SULT、GST 等酶的结构、功能、组织分布及临床意义。</span><br />
</p><br />
<br />
<p style="margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;"><br />
[2] <strong>Guillemette C. (2003).</strong> <em>Pharmacogenomics of human UDP-glucuronosyltransferase enzymes.</em> <strong>[[Pharmacogenomics Journal]]</strong>.<br><br />
<span style="color: #475569;">[遗传学]：详细阐述了 UGT1A1*28 多态性（吉尔伯特综合征）如何影响伊立替康等药物的代谢和毒性。</span><br />
</p><br />
<br />
<p style="margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;"><br />
[3] <strong>Goodman & Gilman's: The Pharmacological Basis of Therapeutics.</strong> <em>13th Edition.</em><br><br />
<span style="color: #475569;">[教科书]：权威定义了 II 相反应为“解毒”途径，并解释了“肠肝循环”对药物半衰期的延长作用。</span><br />
</p><br />
</div><br />
<br />
<div style="margin: 40px 0; border: 1px solid #e2e8f0; border-radius: 8px; overflow: hidden; font-family: 'Helvetica Neue', Arial, sans-serif; font-size: 0.9em;"><br />
<div style="background-color: #eff6ff; color: #1e40af; padding: 8px 15px; font-weight: bold; text-align: center; border-bottom: 1px solid #dbeafe;"><br />
II 相代谢 · 知识图谱<br />
</div><br />
<table style="width: 100%; border-collapse: collapse; background-color: #ffffff;"><br />
<tr style="border-bottom: 1px solid #f1f5f9;"><br />
<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">前置步骤</td><br />
<td style="padding: 10px 15px; color: #334155;">← <strong>[[I相代谢]]</strong> (提供官能团)</td><br />
</tr><br />
<tr style="border-bottom: 1px solid #f1f5f9;"><br />
<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">关键酶类</td><br />
<td style="padding: 10px 15px; color: #334155;"><strong>[[UGT]]</strong> (胆红素代谢) • <strong>[[GST]]</strong> (解毒) • NAT</td><br />
</tr><br />
<tr style="border-bottom: 1px solid #f1f5f9;"><br />
<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">特殊循环</td><br />
<td style="padding: 10px 15px; color: #334155;"><strong>[[肠肝循环]]</strong> (细菌水解 -> 重吸收)</td><br />
</tr><br />
<tr><br />
<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">临床风险</td><br />
<td style="padding: 10px 15px; color: #334155;">UGT1A1 突变 (伊立替康毒性) • 灰婴综合征</td><br />
</tr><br />
</table><br />
</div><br />
<br />
</div></div>
77921020