https://www.yiliao.com/index.php?action=history&feed=atom&title=Hepatology
Hepatology - 版本历史
2026-04-21T09:07:15Z
本wiki的该页面的版本历史
MediaWiki 1.35.1
https://www.yiliao.com/index.php?title=Hepatology&diff=312575&oldid=prev
77921020：建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面
2026-01-03T17:46:47Z
<p>建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面</p>
<p><b>新页面</b></p><div><div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff; max-width: 1200px; margin: auto;"><br />
<br />
<div style="margin-bottom: 30px; border-bottom: 1.2px solid #e2e8f0; padding-bottom: 25px;"><br />
<p style="font-size: 1.1em; margin: 10px 0; color: #334155; text-align: justify;"><br />
<strong>Hepatology</strong> 是 <strong>[[AASLD]]</strong>（American Association for the Study of Liver Diseases，美国肝病研究学会）的官方旗舰月刊，创刊于 1981 年。作为北美乃至全球肝脏病学领域的传统霸主，Hepatology 长期以来被视为该学科的“黄金标准”。与欧洲对手 <strong>[[Journal of Hepatology]]</strong> 相比，Hepatology 以对<strong>[[基础科学]]</strong>（Basic Science）和<strong>[[转化医学]]</strong>的严苛要求而著称。它是发表肝脏免疫学、纤维化机制以及 <strong>[[AASLD诊疗指南]]</strong> 的主要平台，其定义的 <strong>[[NASH CRN]]</strong> 病理评分系统至今仍是全球诊断脂肪肝的病理学金标准。<br />
</p><br />
</div><br />
<br />
<div class="medical-infobox mw-collapsible mw-collapsed" style="width: 100%; max-width: 320px; margin: 0 auto 35px auto; border: 1.2px solid #bae6fd; border-radius: 12px; background-color: #ffffff; box-shadow: 0 8px 20px rgba(0,0,0,0.05); overflow: hidden;"><br />
<br />
<div style="padding: 15px; color: #1e40af; background: linear-gradient(135deg, #e0f2fe 0%, #bae6fd 100%); text-align: center; cursor: pointer;"><br />
<div style="font-size: 1.2em; font-weight: bold; letter-spacing: 1.2px;">Hepatology</div><br />
<div style="font-size: 0.7em; opacity: 0.85; margin-top: 4px; white-space: nowrap;">(点击展开)</div><br />
</div><br />
<br />
<div class="mw-collapsible-content"><br />
<div style="padding: 25px; text-align: center; background-color: #f8fafc;"><br />
<div style="display: inline-block; background: #ffffff; border: 1px solid #e2e8f0; border-radius: 12px; padding: 20px; box-shadow: 0 4px 10px rgba(0,0,0,0.04);"><br />
[[Image:Hepatology_Journal_Logo.png|100px|AASLD 旗舰]]<br />
</div><br />
<div style="font-size: 0.8em; color: #64748b; margin-top: 12px; font-weight: 600;">美式肝病的权威</div><br />
</div><br />
<br />
<table style="width: 100%; border-spacing: 0; border-collapse: collapse; font-size: 0.85em;"><br />
<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; width: 40%;">创刊年份</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">1981年</td><br />
</tr><br />
<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">出版机构</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;">[[Wolters Kluwer]] (AASLD)</td><br />
</tr><br />
<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">协会隶属</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">[[美国肝病研究学会]] (AASLD)</td><br />
</tr><br />
<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">影响因子</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #b91c1c; font-weight: bold;">12.9 (2023 JCR)</td><br />
</tr><br />
<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">主要对手</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">Journal of Hepatology (EASL)</td><br />
</tr><br />
<tr><br />
<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569;">核心标签</th><br />
<td style="padding: 6px 12px; color: #1e40af;">[[病理标准]], [[基础机制]]</td><br />
</tr><br />
</table><br />
</div><br />
</div><br />
<br />
<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">期刊地位：跨大西洋的对决</h2><br />
<br />
<p style="margin: 15px 0; text-align: justify;"><br />
Hepatology 与欧洲的 <em>Journal of Hepatology</em> 构成了肝脏病学的“双子星”。虽然近年来在 IF 竞赛中略逊于欧洲对手，但 Hepatology 在<strong>北美学术界</strong>的地位不可动摇。它被认为更偏向于“科学家”（Scientists），对实验设计的严谨性和分子机制的深度有着近乎洁癖的要求。它是关于<strong>[[肝纤维化]]</strong>逆转机制和<strong>[[丙肝]]</strong>（HCV）治愈机制研究的核心档案库。<br />
</p><br />
<br />
<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">横向测评：肝脏领域顶刊</h2><br />
<br />
<p style="margin: 15px 0; text-align: justify;"><br />
在肝病领域，选择投稿 Hepatology 还是 Journal of Hepatology 往往取决于研究的侧重点。<br />
</p><br />
<br />
<div style="overflow-x: auto; margin: 30px auto; max-width: 100%;"><br />
<table style="width: 100%; border-collapse: collapse; border: 1.2px solid #cbd5e1; font-size: 0.9em; text-align: left;"><br />
<tr style="background-color: #f1f5f9; border-bottom: 2px solid #0f172a;"><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 25%;">期刊</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569;">归属</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af;">IF (2023)</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a;">核心气质与差异</th><br />
</tr><br />
<tr><br />
<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #ffffff;">[[Hepatology]]</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;">AASLD (USA)</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1; color: #64748b;">12.9</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;"><strong>“美式经典”。</strong> 基础研究极其扎实。是 <strong>[[病理学]]</strong> 评分系统（如 NASH CRN）的诞生地。如果你做的是深度的分子机制，这里是首选。</td><br />
</tr><br />
<tr><br />
<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #f8fafc;">[[Journal of Hepatology]]</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;">EASL (EU)</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1; color: #b91c1c; font-weight:bold;">26.8</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;"><strong>“欧洲霸主”。</strong> 目前 IF 领先。更关注临床队列、公共卫生和新概念（如 MASLD 更名）。风格更现代、节奏更快。</td><br />
</tr><br />
<tr><br />
<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #ffffff;">[[Gastroenterology]]</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;">AGA</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1; color: #b91c1c; font-weight:bold;">25.7</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;"><strong>“综合旗舰”。</strong> 涵盖整个消化道。如果研究涉及<strong>[[肠肝轴]]</strong>或极其基础的细胞生物学，Gastroenterology 也是顶级选择。</td><br />
</tr><br />
<tr><br />
<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #f8fafc;">[[Liver Transplantation]]</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;">AASLD</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1; color: #64748b;">4.7</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;"><strong>“移植垂直”。</strong> AASLD 的子刊。专注于肝移植外科、免疫排斥和供体管理。</td><br />
</tr><br />
</table><br />
</div><br />
<br />
<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">历史贡献：定义疾病标准</h2><br />
<br />
<div style="margin-bottom: 25px; border: 1px solid #e2e8f0; border-radius: 8px; padding: 20px; background-color: #ffffff;"><br />
<h3 style="margin-top: 0; color: #1e40af; font-size: 1.1em; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;">The NASH CRN Scoring System</h3><br />
<p style="text-align: justify; color: #334155;"><br />
2005 年，Kleiner 等人在 Hepatology 上发表了由 NIH 资助的 <strong>[[NASH CRN]]</strong> 病理评分系统。这篇论文定义了如何通过显微镜下的脂肪变性、气球样变和炎症来诊断 NASH（非酒精性脂肪性肝炎）。这一系统至今仍是全球药企开发 NASH/MASH 药物时必须遵循的 FDA 审批金标准。<br />
</p><br />
</div><br />
<br />
<div style="font-size: 0.92em; line-height: 1.6; color: #1e293b; margin-top: 50px; border-top: 2px solid #0f172a; padding: 15px 25px; background-color: #f8fafc; border-radius: 0 0 10px 10px;"><br />
<span style="color: #0f172a; font-weight: bold; font-size: 1.05em; display: inline-block; margin-bottom: 15px;">关键参考文献</span><br />
<br />
<p style="margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;"><br />
[1] <strong>Kleiner DE, et al. (2005).</strong> <em>Design and validation of a histological scoring system for nonalcoholic fatty liver disease.</em> <strong>[[Hepatology]]</strong>.<br><br />
<span style="color: #475569;">[引用之王]：这篇论文被引用数千次，确立了<strong>[[NAS评分]]</strong>（NAFLD Activity Score），是肝脏病理学的基石。</span><br />
</p><br />
<br />
<p style="margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;"><br />
[2] <strong>AASLD / IDSA. (Rolling Updates).</strong> <em>Recommendations for testing, managing, and treating hepatitis C.</em> <strong>[[Hepatology]]</strong>.<br><br />
<span style="color: #475569;">[指南]：AASLD 关于 <strong>[[丙肝]]</strong>（HCV）直接抗病毒药物（DAA）的治疗指南，直接指导了美国消除丙肝的临床实践。</span><br />
</p><br />
</div><br />
<br />
<div style="margin: 40px 0; border: 1px solid #e2e8f0; border-radius: 8px; overflow: hidden; font-family: 'Helvetica Neue', Arial, sans-serif; font-size: 0.9em;"><br />
<div style="background-color: #eff6ff; color: #1e40af; padding: 8px 15px; font-weight: bold; text-align: center; border-bottom: 1px solid #dbeafe;"><br />
Hepatology · 知识图谱<br />
</div><br />
<table style="width: 100%; border-collapse: collapse; background-color: #ffffff;"><br />
<tr style="border-bottom: 1px solid #f1f5f9;"><br />
<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">上级品牌</td><br />
<td style="padding: 10px 15px; color: #334155;">[[AASLD]] (American Association for the Study of Liver Diseases)</td><br />
</tr><br />
<tr style="border-bottom: 1px solid #f1f5f9;"><br />
<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">核心议题</td><br />
<td style="padding: 10px 15px; color: #334155;">[[肝纤维化]] • [[酒精性肝病]] • [[肝移植]] • [[MASH]]</td><br />
</tr><br />
<tr style="border-bottom: 1px solid #f1f5f9;"><br />
<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">竞争对手</td><br />
<td style="padding: 10px 15px; color: #334155;">[[Journal of Hepatology]] • [[Gastroenterology]]</td><br />
</tr><br />
<tr><br />
<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">子刊</td><br />
<td style="padding: 10px 15px; color: #334155;">[[Liver Transplantation]] • [[Clinical Liver Disease]] • [[Hepatology Communications]] (OA)</td><br />
</tr><br />
</table><br />
</div><br />
<br />
</div></div>
77921020