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Cancer Discovery - 版本历史
2026-04-21T08:37:03Z
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2026-01-03T16:50:08Z
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<strong>Cancer Discovery</strong> 是 <strong>[[AACR]]</strong>（美国癌症研究协会）于 2011 年重磅推出的顶级旗舰期刊。它的诞生带有强烈的战略意图：即代表 AACR 在高端肿瘤学出版领域重新夺回话语权，直接对标 <strong>[[Cancer Cell]]</strong> 和 <strong>[[Nature Medicine]]</strong>。与 AACR 旗下的老牌期刊 <strong>[[Cancer Research]]</strong> 相比，Cancer Discovery 更加精英化和高门槛。它专注于发表<strong>[[转化医学]]</strong>、<strong>[[精准肿瘤学]]</strong>以及早期临床试验中的重大突破，特别青睐那些能通过深层分子机制解释临床现象（如<strong>[[耐药性]]</strong>）的研究。<br />
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<div style="font-size: 1.2em; font-weight: bold; letter-spacing: 1.2px;">Cancer Discovery</div><br />
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[[Image:Cancer_Discovery_Logo.png|100px|AACR 旗舰]]<br />
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<div style="font-size: 0.8em; color: #64748b; margin-top: 12px; font-weight: 600;">转化医学的最高峰</div><br />
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<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">2011年</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">出版机构</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;">[[AACR]]</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">出版频率</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">月刊 (Monthly)</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">影响因子</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #b91c1c; font-weight: bold;">28.0 (2023 JCR)</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">定位</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">基础与临床的桥梁</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569;">核心标签</th><br />
<td style="padding: 6px 12px; color: #1e40af;">[[精准医疗]], [[药物研发]]</td><br />
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在 2000 年代初期，随着 <em>Cancer Cell</em> (Cell Press) 的崛起，肿瘤学顶刊的话语权逐渐从 AACR 转移到商业出版巨头手中。为了重塑“全球最大癌症研究组织”的学术权威，AACR 集中资源打造了 <strong>Cancer Discovery</strong>。该刊采用类似 Nature/Science 的“杂志化”运营模式，包含大量的前沿新闻（News In Brief）、观点（Views）和综述，旨在成为肿瘤学家每月必读的“行业情报”。<br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">横向测评：肿瘤学“三巨头”</h2><br />
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Cancer Discovery 现已稳居肿瘤学期刊的第一梯队（Tier 1），与另外两本顶刊形成三足鼎立之势。<br />
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<th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 25%;">期刊</th><br />
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<th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a;">核心气质与差异</th><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #ffffff;">[[Cancer Discovery]]</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;">AACR</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1; color: #b91c1c; font-weight:bold;">28.0</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;"><strong>“转化与精准”。</strong> 侧重于将基因组学发现转化为临床疗法。是 <strong>[[靶向治疗]]</strong> 和 <strong>[[免疫治疗]]</strong> 早期临床试验（伴随深层机制分析）的首选。</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #f8fafc;">[[Cancer Cell]]</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;">Cell Press</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1; color: #b91c1c; font-weight:bold;">48.8</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;"><strong>“机制为王”。</strong> IF 极高。偏好极度详尽的分子生物学机制解析（Mechanism-heavy）。对纯临床试验的接受度略低于 Cancer Discovery。</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #ffffff;">[[Nature Medicine]]</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;">Nature Portfolio</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1; color: #b91c1c; font-weight:bold;">58.7</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;"><strong>“广义医学”。</strong> 涵盖所有医学领域，但肿瘤占大头。对 <strong>[[数字医疗]]</strong>（AI）和大规模临床队列数据极度青睐。影响力覆盖整个医疗界。</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; background-color: #f8fafc;">[[Nature Cancer]]</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;">Nature Portfolio</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1; color: #64748b;">23.5</td><br />
<td style="padding: 8px; border: 1px solid #cbd5e1;"><strong>“新晋挑战者”。</strong> 2020年创刊。定位介于 Cancer Cell 和 Nature Medicine 之间，强调跨学科融合。</td><br />
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<h3 style="margin-top: 0; color: #1e40af; font-size: 1.1em; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;">Drug Resistance (耐药性机制)</h3><br />
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Cancer Discovery 是揭示新型抗癌药（如 <strong>[[KRAS抑制剂]]</strong>、<strong>[[EGFR抑制剂]]</strong>）耐药机制的最权威平台。它不仅报道药物为什么有效，更关注药物为什么失效，以及如何通过联合用药克服耐药。<br />
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<span style="color: #0f172a; font-weight: bold; font-size: 1.05em; display: inline-block; margin-bottom: 15px;">关键参考文献</span><br />
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[1] <strong>Cantley LC, et al. (2011).</strong> <em>AACR Project GENIE: Powering Precision Medicine through an International Consortium.</em> <strong>[[Cancer Discovery]]</strong>.<br><br />
<span style="color: #475569;">[大数据]：AACR 发布的 GENIE 项目（基因组数据共享）的奠基性论文发表于此，确立了期刊在 <strong>[[基因组大数据]]</strong> 领域的地位。</span><br />
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[2] <strong>Canon J, et al. (2019).</strong> <em>The clinical development of KRAS G12C inhibitors.</em> (Related studies).<br><br />
<span style="color: #475569;">[药物研发]：关于 <strong>[[KRAS G12C]]</strong> 抑制剂（如 Sotorasib）的早期关键机制和临床前数据，大量首发于 Cancer Discovery，推动了“不可成药”靶点的突破。</span><br />
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Cancer Discovery · 知识图谱<br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">上级组织</td><br />
<td style="padding: 10px 15px; color: #334155;">[[AACR]] (旗舰刊)</td><br />
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<td style="padding: 10px 15px; color: #334155;">[[液体活检]] • [[免疫检查点]] • [[克隆演化]] • [[新辅助治疗]]</td><br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">竞争对手</td><br />
<td style="padding: 10px 15px; color: #334155;">[[Cancer Cell]] • [[Nature Medicine]] • [[Science Translational Medicine]]</td><br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">关系网</td><br />
<td style="padding: 10px 15px; color: #334155;">与 [[Cancer Research]] 形成高低搭配，类似 Nature 与 Nat Comms 的关系</td><br />
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