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BH3结构域 - 版本历史
2026-04-18T02:02:25Z
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2026年1月28日 (三) 10:24 77921020
2026-01-28T10:24:40Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2026年1月28日 (三) 10:24的版本</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l3" >第3行：</td>
<td colspan="2" class="diff-lineno">第3行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin-bottom: 30px; border-bottom: 1.2px solid #e2e8f0; padding-bottom: 25px;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin-bottom: 30px; border-bottom: 1.2px solid #e2e8f0; padding-bottom: 25px;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="font-size: 1.1em; margin: 10px 0; color: #334155; text-align: justify;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="font-size: 1.1em; margin: 10px 0; color: #334155; text-align: justify;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <strong>BH3 结构域</strong>（Bcl-2 Homology Domain 3）是一个由 9-16 个氨基酸组成的短肽基序，形成典型的<strong>两亲性 <del class="diffchange diffchange-inline">$\alpha$</del>-螺旋</strong>结构。它是 <strong>[[Bcl-2]]</strong> 家族蛋白之间进行二聚化和相互作用的核心“接口”。在功能上，BH3 结构域充当“死亡配体”，能够嵌入抗凋亡蛋白（如 Bcl-2, Bcl-xL）表面的疏水凹槽中，从而中和其抗凋亡功能，释放促凋亡蛋白（如 [[Bax]]/[[Bak]]），导致线粒体外膜通透性增加（MOMP）和细胞凋亡。此外，自噬蛋白 <strong>[[Beclin-1]]</strong> 也含有一个非典型的 BH3 结构域，使其能被 Bcl-2 结合并抑制，从而介导凋亡与自噬的交互调控。</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <strong>BH3 结构域</strong>（Bcl-2 Homology Domain 3）是一个由 9-16 个氨基酸组成的短肽基序，形成典型的<strong>两亲性 <ins class="diffchange diffchange-inline">α</ins>-螺旋</strong>结构。它是 <strong>[[Bcl-2]]</strong> 家族蛋白之间进行二聚化和相互作用的核心“接口”。在功能上，BH3 结构域充当“死亡配体”，能够嵌入抗凋亡蛋白（如 Bcl-2, Bcl-xL）表面的疏水凹槽中，从而中和其抗凋亡功能，释放促凋亡蛋白（如 [[Bax]]/[[Bak]]），导致线粒体外膜通透性增加（MOMP）和细胞凋亡。此外，自噬蛋白 <strong>[[Beclin-1]]</strong> 也含有一个非典型的 BH3 结构域，使其能被 Bcl-2 结合并抑制，从而介导凋亡与自噬的交互调控。</div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l30" >第30行：</td>
<td colspan="2" class="diff-lineno">第30行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0;">二级结构</th></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0;">二级结构</th></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;">两亲性 <del class="diffchange diffchange-inline">$\alpha$</del>-螺旋 (Amphipathic Helix)</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;">两亲性 <ins class="diffchange diffchange-inline">α</ins>-螺旋 (Amphipathic Helix)</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l86" >第86行：</td>
<td colspan="2" class="diff-lineno">第86行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <br>抗凋亡蛋白（如 Bcl-2, Bcl-xL, Mcl-1）表面都存在一个细长的疏水凹槽，由 BH1、BH2 和 BH3 结构域共同折叠形成。这个凹槽是结合配体的核心区域。</li></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <br>抗凋亡蛋白（如 Bcl-2, Bcl-xL, Mcl-1）表面都存在一个细长的疏水凹槽，由 BH1、BH2 和 BH3 结构域共同折叠形成。这个凹槽是结合配体的核心区域。</li></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 12px;"><strong>两亲性螺旋 (The Key)：</strong> </div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 12px;"><strong>两亲性螺旋 (The Key)：</strong> </div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <br>BH3-only 蛋白（如 Bim, Puma）的 BH3 结构域形成一个 <del class="diffchange diffchange-inline">$\alpha$</del>-螺旋。螺旋的一侧排列着疏水氨基酸（如亮氨酸），正好插入 Bcl-2 的疏水凹槽中；另一侧则是带电荷氨基酸，暴露在溶剂中。</li></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <br>BH3-only 蛋白（如 Bim, Puma）的 BH3 结构域形成一个 <ins class="diffchange diffchange-inline">α</ins>-螺旋。螺旋的一侧排列着疏水氨基酸（如亮氨酸），正好插入 Bcl-2 的疏水凹槽中；另一侧则是带电荷氨基酸，暴露在溶剂中。</li></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 12px;"><strong>功能转换模式：</strong> </div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 12px;"><strong>功能转换模式：</strong> </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <br>• <strong>激活剂 (Activators)：</strong> 如 Bim, Bid。它们既能结合抗凋亡蛋白，也能直接结合并激活效应蛋白（Bax/Bak），直接触发 MOMP。</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <br>• <strong>激活剂 (Activators)：</strong> 如 Bim, Bid。它们既能结合抗凋亡蛋白，也能直接结合并激活效应蛋白（Bax/Bak），直接触发 MOMP。</div></td></tr>
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77921020
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2026-01-28T10:22:08Z
<p>建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面</p>
<p><b>新页面</b></p><div><div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff; max-width: 1200px; margin: auto;"><br />
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<strong>BH3 结构域</strong>（Bcl-2 Homology Domain 3）是一个由 9-16 个氨基酸组成的短肽基序，形成典型的<strong>两亲性 $\alpha$-螺旋</strong>结构。它是 <strong>[[Bcl-2]]</strong> 家族蛋白之间进行二聚化和相互作用的核心“接口”。在功能上，BH3 结构域充当“死亡配体”，能够嵌入抗凋亡蛋白（如 Bcl-2, Bcl-xL）表面的疏水凹槽中，从而中和其抗凋亡功能，释放促凋亡蛋白（如 [[Bax]]/[[Bak]]），导致线粒体外膜通透性增加（MOMP）和细胞凋亡。此外，自噬蛋白 <strong>[[Beclin-1]]</strong> 也含有一个非典型的 BH3 结构域，使其能被 Bcl-2 结合并抑制，从而介导凋亡与自噬的交互调控。<br />
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<div style="font-size: 1.2em; font-weight: bold; letter-spacing: 1.2px;">BH3 结构域</div><br />
<div style="font-size: 0.7em; opacity: 0.85; margin-top: 4px; white-space: nowrap;">Bcl-2 Homology Domain 3 (点击展开)</div><br />
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[Image:BH3_domain_structure_binding_groove]<br />
<div style="font-size: 0.8em; color: #64748b; margin-top: 12px; font-weight: 600;">机制：α-螺旋插入疏水凹槽</div><br />
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<th colspan="2" style="padding: 8px 12px; background-color: #e0f2fe; color: #1e40af; text-align: left; font-size: 0.9em; border-top: 1px solid #bae6fd;">基础结构参数</th><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0; width: 40%;">全称</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">Bcl-2 Homology 3</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0;">二级结构</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;">两亲性 $\alpha$-螺旋 (Amphipathic Helix)</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0;">长度</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">~9-16 氨基酸</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0;">保守序列</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">L-X-X-X-G-D (亮氨酸-甘氨酸-天冬氨酸)</td><br />
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<th colspan="2" style="padding: 8px 12px; background-color: #e0f2fe; color: #1e40af; text-align: left; font-size: 0.9em; border-top: 1px solid #bae6fd;">功能分类</th><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0;">BH3-Only 蛋白</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #b91c1c;"><strong>促凋亡</strong>: Bim, Bid, Bad, Puma, Noxa</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0;">Multi-Domain</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;"><strong>抗凋亡</strong>: Bcl-2, Bcl-xL, Mcl-1<br><strong>促凋亡</strong>: Bax, Bak</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0;">非 Bcl-2 家族</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #16a34a;"><strong>自噬</strong>: [[Beclin-1]], AMBRA1</td><br />
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<th colspan="2" style="padding: 8px 12px; background-color: #e0f2fe; color: #1e40af; text-align: left; font-size: 0.9em; border-top: 1px solid #bae6fd;">药物研发</th><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0;">药物类别</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">[[BH3模拟物]] (BH3 Mimetics)</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569; border-bottom: 1px solid #e2e8f0;">代表药物</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #16a34a;">[[Venetoclax]] (ABT-199)<br>[[Navitoclax]] (ABT-263)</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f8fafc; color: #475569;">作用机制</th><br />
<td style="padding: 6px 12px; color: #0f172a;">占据抗凋亡蛋白的疏水槽，释放 Bax/Bak</td><br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">分子机制：生与死的锁与钥</h2><br />
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BH3 结构域的功能依赖于精密的“锁-钥模型”（Lock and Key Model）：<br />
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<li style="margin-bottom: 12px;"><strong>疏水凹槽 (The Lock)：</strong> <br />
<br>抗凋亡蛋白（如 Bcl-2, Bcl-xL, Mcl-1）表面都存在一个细长的疏水凹槽，由 BH1、BH2 和 BH3 结构域共同折叠形成。这个凹槽是结合配体的核心区域。</li><br />
<li style="margin-bottom: 12px;"><strong>两亲性螺旋 (The Key)：</strong> <br />
<br>BH3-only 蛋白（如 Bim, Puma）的 BH3 结构域形成一个 $\alpha$-螺旋。螺旋的一侧排列着疏水氨基酸（如亮氨酸），正好插入 Bcl-2 的疏水凹槽中；另一侧则是带电荷氨基酸，暴露在溶剂中。</li><br />
<li style="margin-bottom: 12px;"><strong>功能转换模式：</strong> <br />
<br>• <strong>激活剂 (Activators)：</strong> 如 Bim, Bid。它们既能结合抗凋亡蛋白，也能直接结合并激活效应蛋白（Bax/Bak），直接触发 MOMP。<br />
<br>• <strong>增敏剂 (Sensitizers)：</strong> 如 Bad, Noxa。它们只能结合抗凋亡蛋白，将“被囚禁”的激活剂释放出来，间接促进凋亡。</li><br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">临床转化：BH3 模拟物</h2><br />
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<h3 style="margin-top: 0; color: #1e40af; font-size: 1.1em;">从肽到药的飞跃</h3><br />
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科学家发现 BH3 肽段本身虽然能杀癌，但无法穿透细胞膜且不稳定。通过小分子化学修饰，模拟 BH3 螺旋的空间结构，诞生了 <strong>[[BH3模拟物]]</strong>。<br />
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[Image:BH3_mimetics_mechanism_venetoclax]<br />
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<th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 25%;">药物名称</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569;">模拟对象</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af;">靶点选择性</th><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">[[Venetoclax]] (ABT-199)</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">Bad 的 BH3 结构域</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1; color: #16a34a;">高度选择性抑制 <strong>Bcl-2</strong>。治疗 CLL/AML 的特效药。</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">[[Navitoclax]] (ABT-263)</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">Bad 的 BH3 结构域</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">抑制 Bcl-2 和 Bcl-xL。副作用大（血小板减少，因 Bcl-xL 对血小板存活至关重要）。</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">S63845 / AMG-176</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">Mcl-1 特异性 BH3</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">特异性抑制 <strong>Mcl-1</strong>。目前处于临床试验阶段。</td><br />
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BH3 结构域 · 知识图谱<br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle;">抗凋亡靶点</td><br />
<td style="padding: 10px 15px; color: #334155;">[[Bcl-2]] • [[Bcl-xL]] • [[Mcl-1]] • [[Bcl-w]]</td><br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle;">BH3-Only</td><br />
<td style="padding: 10px 15px; color: #334155;">[[Bim]] (强效) • [[Bid]] (截断型tBid) • [[Puma]] (p53下游) • [[Bad]]</td><br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle;">非凋亡功能</td><br />
<td style="padding: 10px 15px; color: #334155;">[[Beclin-1]] (自噬) • [[AMBRA1]] (自噬/线粒体)</td><br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle;">相关药物</td><br />
<td style="padding: 10px 15px; color: #334155;">[[Venetoclax]] • [[Navitoclax]] • [[Obatoclax]]</td><br />
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