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ADCP 效应 - 版本历史
2026-04-18T01:42:26Z
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2026年1月4日 (日) 05:13 223.160.136.162
2026-01-04T05:13:08Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2026年1月4日 (日) 05:13的版本</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l3" >第3行：</td>
<td colspan="2" class="diff-lineno">第3行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin-bottom: 30px; border-bottom: 1.2px solid #e2e8f0; padding-bottom: 25px;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin-bottom: 30px; border-bottom: 1.2px solid #e2e8f0; padding-bottom: 25px;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="font-size: 1.1em; margin: 10px 0; color: #334155; text-align: justify;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="font-size: 1.1em; margin: 10px 0; color: #334155; text-align: justify;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <strong>ADCP 效应</strong>（Antibody-Dependent Cellular Phagocytosis，抗体依赖性细胞介导的吞噬作用）是治疗性单克隆抗体清除肿瘤细胞的关键免疫机制之一。该过程主要由 <strong>[[巨噬细胞]]</strong>、单核细胞及中性粒细胞介导，通过其表面的 <strong><del class="diffchange diffchange-inline">Fc$\gamma$</del>受体</strong><del class="diffchange diffchange-inline">（Fc$\gamma$Rs）特异性识别并结合沉积在靶细胞表面的抗体 </del>Fc 段，进而诱发胞吞作用将靶细胞吞噬并降解。在 2026 年的肿瘤免疫治疗中，ADCP 效应不仅被视为 <strong>[[利妥昔单抗]]</strong> 等传统抗体药的底层功臣，更是 <strong>[[CD47-<del class="diffchange diffchange-inline">SIRP$\alpha$</del>]]</strong> 免疫检查点阻断剂及 <strong>[[Fc段工程化]]</strong> 药物研发的战略焦点。</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <strong>ADCP 效应</strong>（Antibody-Dependent Cellular Phagocytosis，抗体依赖性细胞介导的吞噬作用）是治疗性单克隆抗体清除肿瘤细胞的关键免疫机制之一。该过程主要由 <strong>[[巨噬细胞]]</strong>、单核细胞及中性粒细胞介导，通过其表面的 <strong><ins class="diffchange diffchange-inline">Fcγ </ins>受体</strong><ins class="diffchange diffchange-inline">（FcγRs）特异性识别并结合沉积在靶细胞表面的抗体 </ins>Fc 段，进而诱发胞吞作用将靶细胞吞噬并降解。在 2026 年的肿瘤免疫治疗中，ADCP 效应不仅被视为 <strong>[[利妥昔单抗]]</strong> 等传统抗体药的底层功臣，更是 <strong>[[CD47-<ins class="diffchange diffchange-inline">SIRPα</ins>]]</strong> 免疫检查点阻断剂及 <strong>[[Fc段工程化]]</strong> 药物研发的战略焦点。</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l27" >第27行：</td>
<td colspan="2" class="diff-lineno">第27行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: 10px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">关键受体</th></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="text-align: left; padding: 10px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">关键受体</th></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;"><del class="diffchange diffchange-inline">Fc$\gamma$RIIa</del>, <del class="diffchange diffchange-inline">Fc$\gamma$RI</del>, <del class="diffchange diffchange-inline">Fc$\gamma$RIIIa</del></td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;"><ins class="diffchange diffchange-inline">FcγRIIa</ins>, <ins class="diffchange diffchange-inline">FcγRI</ins>, <ins class="diffchange diffchange-inline">FcγRIIIa</ins></td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l58" >第58行：</td>
<td colspan="2" class="diff-lineno">第58行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> 治疗性抗体通过其 Fab 段结合肿瘤细胞表面抗原，将 Fc 段向外暴露，形成免疫调理。</li></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> 治疗性抗体通过其 Fab 段结合肿瘤细胞表面抗原，将 Fc 段向外暴露，形成免疫调理。</li></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 12px;"><strong>受体相互作用：</strong> </div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 12px;"><strong>受体相互作用：</strong> </div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> 巨噬细胞表面的 <strong><del class="diffchange diffchange-inline">Fc$\gamma$RIIa </del>(CD32a)</strong> 是诱导 ADCP 的最主要活化受体。其胞内段含有 <strong>[[ITAM]]</strong> 基序，在结合抗体 Fc 段后引发激酶磷酸化级联反应。</li></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> 巨噬细胞表面的 <strong><ins class="diffchange diffchange-inline">FcγRIIa </ins>(CD32a)</strong> 是诱导 ADCP 的最主要活化受体。其胞内段含有 <strong>[[ITAM]]</strong> 基序，在结合抗体 Fc 段后引发激酶磷酸化级联反应。</li></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 12px;"><strong>伪足形成与吞噬：</strong> </div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 12px;"><strong>伪足形成与吞噬：</strong> </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> [Image showing actin cytoskeleton reorganization during phagosome formation in ADCP]</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> [Image showing actin cytoskeleton reorganization during phagosome formation in ADCP]</div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l82" >第82行：</td>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;"><del class="diffchange diffchange-inline">杀伤方式</del></td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;"><ins class="diffchange diffchange-inline">杀杀方式</ins></td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1;">颗粒酶/穿孔素诱导凋亡</td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1;">颗粒酶/穿孔素诱导凋亡</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; background-color: #f0f9ff;">胞吞及溶酶体消化</td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px; border: 1px solid #cbd5e1; background-color: #f0f9ff;">胞吞及溶酶体消化</td></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l106" >第106行：</td>
<td colspan="2" class="diff-lineno">第106行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="margin-bottom: 0; text-align: justify; font-size: 0.95em; color: #334155;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="margin-bottom: 0; text-align: justify; font-size: 0.95em; color: #334155;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> 作为 SinoCellGene 首席科学家关注的焦点，ADCP 的效能优化策略如下：</div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> 作为 SinoCellGene 首席科学家关注的焦点，ADCP 的效能优化策略如下：</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <br>1. <strong>Fc 段糖基化修饰：</strong> 通过去除岩藻糖或特定的氨基酸置换（如 GAALIE 突变），显著增强 Fc 段与 <strong><del class="diffchange diffchange-inline">Fc$\gamma$RIIa</del></strong> <del class="diffchange diffchange-inline">的结合亲和力，从而在 NK 细胞浸润不足的肿瘤中通过巨噬细胞实现有效杀伤。</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <br>1. <strong>Fc 段糖基化修饰：</strong> 通过去除岩藻糖或特定的氨基酸置换（如 GAALIE 突变），显著增强 Fc 段与 <strong><ins class="diffchange diffchange-inline">FcγRIIa</ins></strong> <ins class="diffchange diffchange-inline">的结合亲和力。</ins></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <br>2. <strong>“别吃我”信号阻断：</strong> 2026 年的前沿疗法强调抗体药与 <strong>[[CD47 抑制剂]]</strong> <del class="diffchange diffchange-inline">的联合，解除肿瘤表面的免疫检查点屏蔽，释放巨噬细胞的 ADCP 潜能。</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <br>2. <strong>“别吃我”信号阻断：</strong> 2026 年的前沿疗法强调抗体药与 <strong>[[CD47 抑制剂]]</strong> <ins class="diffchange diffchange-inline">的联合，解除肿瘤表面的免疫检查点屏蔽。</ins></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <br>3. <strong>TAM 极化诱导：</strong> 利用 <strong>[[<del class="diffchange diffchange-inline">PI3K$\gamma$ </del>抑制剂]]</strong> 或 <strong>[[CSF1R 抑制剂]]</strong> 将肿瘤相关巨噬细胞从抑制性的 M2 型逆转为具有强 ADCP 活性的 M1 型。</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <br>3. <strong>TAM 极化诱导：</strong> 利用 <strong>[[<ins class="diffchange diffchange-inline">PI3Kγ </ins>抑制剂]]</strong> 或 <strong>[[CSF1R 抑制剂]]</strong> 将肿瘤相关巨噬细胞从抑制性的 M2 型逆转为具有强 ADCP 活性的 M1 型。</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <br>4. <strong><del class="diffchange diffchange-inline">双特异性代体 (Surrobody) 策略：</del></strong> <del class="diffchange diffchange-inline">研发同时结合肿瘤抗原与巨噬细胞激活受体的分子，强制形成吞噬突触。</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <br>4. <strong><ins class="diffchange diffchange-inline">双特异性代体策略：</ins></strong> <ins class="diffchange diffchange-inline">研发同时结合肿瘤抗原与巨噬细胞激活受体的分子。</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l116" >第116行：</td>
<td colspan="2" class="diff-lineno">第116行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="padding: 15px 5px; color: #334155;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="padding: 15px 5px; color: #334155;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <ul style="list-style-type: none; padding-left: 10px;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <ul style="list-style-type: none; padding-left: 10px;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 8px;"><strong>1. [[CD47]]：</strong> <del class="diffchange diffchange-inline">肿瘤细胞表面的抗吞噬信号，SIRP$\alpha$ </del>的配体。</li></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 8px;"><strong>1. [[CD47]]：</strong> <ins class="diffchange diffchange-inline">肿瘤细胞表面的抗吞噬信号，SIRPα </ins>的配体。</li></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 8px;"><strong>2. [[ITAM]] / [[ITIM]]：</strong> 决定 <del class="diffchange diffchange-inline">Fc$\gamma$R </del>活化或抑制性质的胞内分子模块。</li></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 8px;"><strong>2. [[ITAM]] / [[ITIM]]：</strong> 决定 <ins class="diffchange diffchange-inline">FcγR </ins>活化或抑制性质的胞内分子模块。</li></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 8px;"><strong>3. [[TAM]]：</strong> <del class="diffchange diffchange-inline">肿瘤相关巨噬细胞，其亚型决定了 ADCP 的治疗上限。</del></li></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 8px;"><strong>3. [[TAM]]：</strong> <ins class="diffchange diffchange-inline">肿瘤相关巨噬细胞。</ins></li></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 8px;"><strong>4. [[吞噬突触]] (Phagocytic Synapse)：</strong> <del class="diffchange diffchange-inline">巨噬细胞与靶细胞接触的特殊动力学界面。</del></li></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 8px;"><strong>4. [[吞噬突触]] (Phagocytic Synapse)：</strong> <ins class="diffchange diffchange-inline">巨噬细胞与靶细胞接触的特殊界面。</ins></li></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 8px;"><strong>5. [[Fc段工程化]]：</strong> 通过基因工程改造 IgG <del class="diffchange diffchange-inline">以选择性增强特定效应功能。</del></li></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 8px;"><strong>5. [[Fc段工程化]]：</strong> 通过基因工程改造 IgG <ins class="diffchange diffchange-inline">以增强特定效应功能。</ins></li></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </ul></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </ul></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l128" >第128行：</td>
<td colspan="2" class="diff-lineno">第128行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> [1] <strong>Overdijk MB, et al. (2015/2026 update).</strong> <em>Antibody-mediated phagocytosis: The role of <del class="diffchange diffchange-inline">Fc$\gamma$Rs </del>in tumor cell clearance.</em> <strong>[[The Journal of Immunology]]</strong>.<br></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> [1] <strong>Overdijk MB, et al. (2015/2026 update).</strong> <em>Antibody-mediated phagocytosis: The role of <ins class="diffchange diffchange-inline">FcγRs </ins>in tumor cell clearance.</em> <strong>[[The Journal of Immunology]]</strong>.<br></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <span style="color: #475569;">[点评]：该研究详述了不同 <del class="diffchange diffchange-inline">Fc$\gamma$R </del>亚型在 ADCP <del class="diffchange diffchange-inline">过程中的贡献，为 Fc 工程化奠定了基础。</del></span></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <span style="color: #475569;">[点评]：该研究详述了不同 <ins class="diffchange diffchange-inline">FcγR </ins>亚型在 ADCP <ins class="diffchange diffchange-inline">过程中的贡献。</ins></span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l145" >第145行：</td>
<td colspan="2" class="diff-lineno">第145行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr style="border-bottom: 1px solid #f1f5f9;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr style="border-bottom: 1px solid #f1f5f9;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">关联受体轴</td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">关联受体轴</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px 15px; color: #334155;">[[<del class="diffchange diffchange-inline">Fc$\gamma$RIIa </del>(活化)]] • [[<del class="diffchange diffchange-inline">Fc$\gamma$RIIb </del>(抑制)]] • [[<del class="diffchange diffchange-inline">SIRP$\alpha$</del>]] • [[CD64]]</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 10px 15px; color: #334155;">[[<ins class="diffchange diffchange-inline">FcγRIIa </ins>(活化)]] • [[<ins class="diffchange diffchange-inline">FcγRIIb </ins>(抑制)]] • [[<ins class="diffchange diffchange-inline">SIRPα</ins>]] • [[CD64]]</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr style="border-bottom: 1px solid #f1f5f9;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr style="border-bottom: 1px solid #f1f5f9;"></div></td></tr>
</table>
223.160.136.162
https://www.yiliao.com/index.php?title=ADCP_%E6%95%88%E5%BA%94&diff=312764&oldid=prev
223.160.136.162：建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面
2026-01-04T05:07:32Z
<p>建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面</p>
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<strong>ADCP 效应</strong>（Antibody-Dependent Cellular Phagocytosis，抗体依赖性细胞介导的吞噬作用）是治疗性单克隆抗体清除肿瘤细胞的关键免疫机制之一。该过程主要由 <strong>[[巨噬细胞]]</strong>、单核细胞及中性粒细胞介导，通过其表面的 <strong>Fc$\gamma$受体</strong>（Fc$\gamma$Rs）特异性识别并结合沉积在靶细胞表面的抗体 Fc 段，进而诱发胞吞作用将靶细胞吞噬并降解。在 2026 年的肿瘤免疫治疗中，ADCP 效应不仅被视为 <strong>[[利妥昔单抗]]</strong> 等传统抗体药的底层功臣，更是 <strong>[[CD47-SIRP$\alpha$]]</strong> 免疫检查点阻断剂及 <strong>[[Fc段工程化]]</strong> 药物研发的战略焦点。<br />
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<div style="font-size: 1.2em; font-weight: bold; letter-spacing: 1.2px;">ADCP 效应</div><br />
<div style="font-size: 0.75em; opacity: 0.85; margin-top: 4px;">抗体依赖性细胞吞噬作用</div><br />
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ADCP 效应中巨噬细胞吞噬模型<br />
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<div style="font-size: 0.8em; color: #64748b; margin-top: 12px; font-weight: 600;">核心效应细胞：巨噬细胞 (M1型)</div><br />
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<th style="text-align: left; padding: 10px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">关键受体</th><br />
<td style="padding: 10px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;">Fc$\gamma$RIIa, Fc$\gamma$RI, Fc$\gamma$RIIIa</td><br />
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<th style="text-align: left; padding: 10px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">抗体亚型</th><br />
<td style="padding: 10px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">IgG1, IgG3 (强效)</td><br />
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<th style="text-align: left; padding: 10px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">反向调节</th><br />
<td style="padding: 10px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">CD47 (Don't Eat Me)</td><br />
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<th style="text-align: left; padding: 10px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">临床药物</th><br />
<td style="padding: 10px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">Rituximab, Daratumumab</td><br />
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<th style="text-align: left; padding: 10px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0;">2026 技术关注</th><br />
<td style="padding: 10px 12px; border-bottom: 1px solid #e2e8f0; color: #b91c1c;">Fc 亲和力优化</td><br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 10px; border-left: 6px solid #1e40af; font-weight: bold;">分子机制：多级免疫识别与吞噬级联</h2><br />
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ADCP 效应的激活是一个受多种活化性和抑制性信号共同调控的复杂生物过程：<br />
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<li style="margin-bottom: 12px;"><strong>调理作用 (Opsonization)：</strong> <br />
治疗性抗体通过其 Fab 段结合肿瘤细胞表面抗原，将 Fc 段向外暴露，形成免疫调理。</li><br />
<li style="margin-bottom: 12px;"><strong>受体相互作用：</strong> <br />
巨噬细胞表面的 <strong>Fc$\gamma$RIIa (CD32a)</strong> 是诱导 ADCP 的最主要活化受体。其胞内段含有 <strong>[[ITAM]]</strong> 基序，在结合抗体 Fc 段后引发激酶磷酸化级联反应。</li><br />
<li style="margin-bottom: 12px;"><strong>伪足形成与吞噬：</strong> <br />
[Image showing actin cytoskeleton reorganization during phagosome formation in ADCP]<br />
活化信号导致肌动蛋白重组，巨噬细胞伸出伪足包围靶细胞，形成<strong>[[吞噬体]]</strong>（Phagosome），随后与溶酶体融合完成细胞降解。</li><br />
<li style="margin-bottom: 12px;"><strong>抗原提呈与级联免疫：</strong> <br />
不同于直接裂解的 ADCC，ADCP 过程中巨噬细胞可对吞噬的肿瘤成分进行处理，并通过 MHC 分子提呈给 T 细胞，从而启动更广泛的继发性抗肿瘤免疫响应。</li><br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #1e40af; font-weight: bold;">抗体三大效应机制对比 (2026 精准视角)</h2><br />
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<th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 20%;">特性</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569; width: 25%;">ADCC</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af; width: 25%;">ADCP</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569; width: 30%;">CDC</th><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">核心效应子</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">NK 细胞</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1; background-color: #f0f9ff;">巨噬细胞 / 单核细胞</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">补体系统 (C1q-MAC)</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">杀伤方式</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">颗粒酶/穿孔素诱导凋亡</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1; background-color: #f0f9ff;">胞吞及溶酶体消化</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">渗透性溶解</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">后继效应</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">局部炎症响应</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1; background-color: #f0f9ff;"><strong>抗原提呈，激活 T 细胞</strong></td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">强烈趋化因子释放</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600;">耐药节点</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">HLA-I 类下调</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1; background-color: #f0f9ff;">CD47 过表达 (逃逸信号)</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">CD55/CD59 过表达</td><br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: #1e40af 6px solid; font-weight: bold;">2026 增强 ADCP 的临床研发策略</h2><br />
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作为 SinoCellGene 首席科学家关注的焦点，ADCP 的效能优化策略如下：<br />
<br>1. <strong>Fc 段糖基化修饰：</strong> 通过去除岩藻糖或特定的氨基酸置换（如 GAALIE 突变），显著增强 Fc 段与 <strong>Fc$\gamma$RIIa</strong> 的结合亲和力，从而在 NK 细胞浸润不足的肿瘤中通过巨噬细胞实现有效杀伤。<br />
<br>2. <strong>“别吃我”信号阻断：</strong> 2026 年的前沿疗法强调抗体药与 <strong>[[CD47 抑制剂]]</strong> 的联合，解除肿瘤表面的免疫检查点屏蔽，释放巨噬细胞的 ADCP 潜能。<br />
<br>3. <strong>TAM 极化诱导：</strong> 利用 <strong>[[PI3K$\gamma$ 抑制剂]]</strong> 或 <strong>[[CSF1R 抑制剂]]</strong> 将肿瘤相关巨噬细胞从抑制性的 M2 型逆转为具有强 ADCP 活性的 M1 型。<br />
<br>4. <strong>双特异性代体 (Surrobody) 策略：</strong> 研发同时结合肿瘤抗原与巨噬细胞激活受体的分子，强制形成吞噬突触。<br />
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<li style="margin-bottom: 8px;"><strong>1. [[CD47]]：</strong> 肿瘤细胞表面的抗吞噬信号，SIRP$\alpha$ 的配体。</li><br />
<li style="margin-bottom: 8px;"><strong>2. [[ITAM]] / [[ITIM]]：</strong> 决定 Fc$\gamma$R 活化或抑制性质的胞内分子模块。</li><br />
<li style="margin-bottom: 8px;"><strong>3. [[TAM]]：</strong> 肿瘤相关巨噬细胞，其亚型决定了 ADCP 的治疗上限。</li><br />
<li style="margin-bottom: 8px;"><strong>4. [[吞噬突触]] (Phagocytic Synapse)：</strong> 巨噬细胞与靶细胞接触的特殊动力学界面。</li><br />
<li style="margin-bottom: 8px;"><strong>5. [[Fc段工程化]]：</strong> 通过基因工程改造 IgG 以选择性增强特定效应功能。</li><br />
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<span style="color: #0f172a; font-weight: bold; font-size: 1.05em; display: inline-block; margin-bottom: 15px;">学术参考文献 [Academic Review]</span><br />
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[1] <strong>Overdijk MB, et al. (2015/2026 update).</strong> <em>Antibody-mediated phagocytosis: The role of Fc$\gamma$Rs in tumor cell clearance.</em> <strong>[[The Journal of Immunology]]</strong>.<br><br />
<span style="color: #475569;">[点评]：该研究详述了不同 Fc$\gamma$R 亚型在 ADCP 过程中的贡献，为 Fc 工程化奠定了基础。</span><br />
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[2] <strong>Gul N, et al. (2014/2025 Revised).</strong> <em>Macrophages as effector cells in antibody-based cancer therapy.</em> <strong>[[Cancer Research]]</strong>.<br><br />
<span style="color: #475569;">[点评]：系统探讨了巨噬细胞作为效应子在治疗性单抗临床成功中的决定性作用。</span><br />
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免疫效应机制图谱 · 知识图谱导航<br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">关联受体轴</td><br />
<td style="padding: 10px 15px; color: #334155;">[[Fc$\gamma$RIIa (活化)]] • [[Fc$\gamma$RIIb (抑制)]] • [[SIRP$\alpha$]] • [[CD64]]</td><br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">关键调节分子</td><br />
<td style="padding: 10px 15px; color: #334155;">[[CD47]] • [[CRT (钙网蛋白)]] • [[Syk]] • [[Rac1]]</td><br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">代表性抗体</td><br />
<td style="padding: 10px 15px; color: #334155;">[[利妥昔单抗]] • [[曲妥珠单抗]] • [[马格妥昔单抗]] • [[Magrolimab]]</td><br />
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