https://www.yiliao.com/index.php?action=history&feed=atom&title=%E9%9E%98%E6%B0%A8%E9%86%87 2026-04-17T19:43:58Z 本wiki的该页面的版本历史 MediaWiki 1.35.1 https://www.yiliao.com/index.php?title=%E9%9E%98%E6%B0%A8%E9%86%87&diff=304009&oldid=prev 2021-07-21T16:33:27Z

<p>建立内容为“{{Chembox | ImageFile = Sphingosine-2D-skeletal.png | ImageSize = | ImageName = Sphingosine | IUPACName = (2&#039;&#039;S&#039;&#039;,3&#039;&#039;R&#039;&#039;)-2-aminooctadec-4-ene-1,3-diol | OtherNa…”的新页面</p> <p><b>新页面</b></p><div>{{Chembox<br /> | ImageFile = Sphingosine-2D-skeletal.png<br /> | ImageSize = <br /> | ImageName = Sphingosine<br /> | IUPACName = (2''S'',3''R'')-2-aminooctadec-4-ene-1,3-diol<br /> | OtherNames = <br /> | Section1 = {{Chembox Identifiers<br /> | CASNo = 123-78-4<br /> | PubChem = 1104<br /> | SMILES = N[C@@H](CO)[C@H](O)\C=C\CCCCCCCCCCCCC<br /> }}<br /> | Section2 = {{Chembox Properties<br /> | C = 18 | H = 37 | N = 1 | O = 2<br /> | Formula = <br /> | MolarMass = <br /> | Appearance = <br /> | Density = <br /> | MeltingPt = <br /> | BoilingPt = <br /> | Solubility = <br /> }}<br /> | Section3 = {{Chembox Hazards<br /> | MainHazards = <br /> | FlashPt = <br /> | Autoignition = <br /> }}<br /> }}<br /> <br /> '''鞘氨醇'''（Sphingosine）又称'''[[神经]]鞘氨醇'''，[[学名]]2-氨基-4-十八烯-1,3-[[二醇]]，是一种含有不饱和烃基链的[[十八碳]]氨基醇。鞘氨醇属于[[鞘脂类]]，为[[细胞膜]]组成成分之一。<br /> <br /> ==功能==<br /> <br /> 鞘氨醇在体内可在两种[[激酶]]——[[鞘氨醇激酶]]1和鞘氨醇激酶2的[[催化]]下被[[磷酸化]]产生[[鞘氨醇-1-磷酸]]，后者是一种有力的信号脂[[类分子]]。<br /> <br /> [[鞘脂]]的[[代谢物]]如[[神经酰胺]]、鞘氨醇与鞘氨醇-1-磷酸，均为信号脂类分子，参与多种[[细胞]]过程。<br /> <br /> == [[生物合成]] ==<br /> <br /> [[棕榈酰]][[CoA]]与[[丝氨酸]]缩合，得到脱氢鞘氨醇。<br /> <br /> &lt;br /&gt; [[Image:Sphingosine synthesis corrected.png||800px|鞘氨醇合成]] &lt;br /&gt;<br /> <br /> 然后脱氢鞘氨醇被NADPH还原为[[二氢鞘氨醇]]，后者再被FAD氧化为鞘氨醇。<br /> <br /> ==参考资料==<br /> * {{cite journal en|author=Radin N |title=Killing tumours by ceramide-induced apoptosis: a critique of available drugs |journal=Biochem J |volume=371 |issue=Pt 2 |pages=243–56 |year=2003 |pmid=12558497 |doi=10.1042/BJ20021878}} [http://www.biochemj.org/bj/371/0243/bj3710243.htm article]<br /> * Carter, H. E., F. J. Glick, W. P. Norris, and G. E. Phillips. 1947. [http://www.jbc.org/cgi/reprint/170/1/285?ijkey=7fd093d3a30af91f599ef98c8f464caa5e41f203&amp;amp;keytype2=tf_ipsecsha Biochemistry of the sphingolipides. III. Structure of sphingosine]. J. Biol. Chem. 170: 285–295<br /> <br /> ==图片==<br /> <br /> &lt;gallery&gt;<br /> <br /> Image:Sphingolipidoses.svg|鞘[[脂贮积病]]<br /> <br /> &lt;/gallery&gt;<br /> <br /> ==外部链接==<br /> * {{MeshName|Sphingosine}}<br /> <br /> {{氨基醇}}<br /> {{鞘脂}}<br /> [[Category:生物分子]]<br /> ==参考来源==<br /> *[http://zh.wikipedia.org/wiki/%E9%9E%98%E6%B0%A8%E9%86%87 维基百科-鞘氨醇]</div>

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