14.36.39.47：建立内容为“{{PBB|geneid=5530}} '''钙调磷酸酶'''[http://www.term.gov.cn/pages/homepage/result2.jsp?id=332126&subid=10001798&subject=%E9%85%B6&subsys=%E7…”的新页面

2021-07-21T18:25:59Z

建立内容为“{{PBB|geneid=5530}} '''钙调磷酸酶'''<ref>[http://www.term.gov.cn/pages/homepage/result2.jsp?id=332126&subid=10001798&subject=%E9%85%B6&subsys=%E7…”的新页面

新页面

{{PBB|geneid=5530}}
'''钙调磷酸酶'''<ref>[http://www.term.gov.cn/pages/homepage/result2.jsp?id=332126&subid=10001798&subject=%E9%85%B6&subsys=%E7%94%9F%E7%89%A9%E5%8C%96%E5%AD%A6%E4%B8%8E%E5%88%86%E5%AD%90%E7%94%9F%E7%89%A9%E5%AD%A6]</ref>（{{lang-en|Calcineurin}}，亦称为[[蛋白磷酸酶]]3或蛋白磷酸酶2B，分别简称为'''PPP3CA'''与'''PP2B'''）其在体内的作用为启动[[T细胞]]并可以通过药物来阻断这一过程。

钙调磷酸酶为很多种[[免疫抑制药]]的作用对象如，[[环孢霉素]],[[吡美莫司]]和[[他克莫司]]。

==参考文献==

{{Reflist}}

==深入阅读==

{{Refbegin | 2}}

{{PBB_Further_reading
| citations =
*{{Cite journal | author=Crabtree GR |title=Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT |journal=Cell |volume=96 |issue= 5 |pages= 611–4 |year= 1999 |pmid= 10089876 |doi= 10.1016/S0092-8674(00)80571-1}}
*{{Cite journal | author=Giri PR, Higuchi S, Kincaid RL |title=Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase (calcineurin) catalytic subunit |journal=Biochem. Biophys. Res. Commun. |volume=181 |issue= 1 |pages= 252–8 |year= 1992 |pmid= 1659808 |doi=10.1016/S0006-291X(05)81410-X }}
*{{Cite journal | author=Kincaid RL, Giri PR, Higuchi S, ''et al.'' |title=Cloning and characterization of molecular isoforms of the catalytic subunit of calcineurin using nonisotopic methods |journal=J. Biol. Chem. |volume=265 |issue= 19 |pages= 11312–9 |year= 1990 |pmid= 2162844 |doi= }}
*{{Cite journal | author=Guerini D, Klee CB |title=Cloning of human calcineurin A: evidence for two isozymes and identification of a polyproline structural domain |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 23 |pages= 9183–7 |year= 1990 |pmid= 2556704 |doi=10.1073/pnas.86.23.9183 | pmc=298458 }}
*{{Cite journal | author=Kincaid RL, Nightingale MS, Martin BM |title=Characterization of a cDNA clone encoding the calmodulin-binding domain of mouse brain calcineurin |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 23 |pages= 8983–7 |year= 1988 |pmid= 2848250 |doi= 10.1073/pnas.85.23.8983 | pmc=282646}}
*{{Cite journal | author=Coghlan VM, Perrino BA, Howard M, ''et al.'' |title=Association of protein kinase A and protein phosphatase 2B with a common anchoring protein |journal=Science |volume=267 |issue= 5194 |pages= 108–11 |year= 1995 |pmid= 7528941 |doi= 10.1126/science.7528941}}
*{{Cite journal | author=Griffith JP, Kim JL, Kim EE, ''et al.'' |title=X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex |journal=Cell |volume=82 |issue= 3 |pages= 507–22 |year= 1995 |pmid= 7543369 |doi= 10.1016/0092-8674(95)90439-5}}
*{{Cite journal | author=Shibasaki F, McKeon F |title=Calcineurin functions in Ca(2+)-activated cell death in mammalian cells |journal=J. Cell Biol. |volume=131 |issue= 3 |pages= 735–43 |year= 1995 |pmid= 7593193 |doi= 10.1083/jcb.131.3.735 | pmc=2120616}}
*{{Cite journal | author=Muramatsu T, Kincaid RL |title=Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase (calcineurin A alpha) |journal=Biochim. Biophys. Acta |volume=1178 |issue= 1 |pages= 117–20 |year= 1993 |pmid= 8392375 |doi=10.1016/0167-4889(93)90117-8 }}
*{{Cite journal | author=Cameron AM, Steiner JP, Roskams AJ, ''et al.'' |title=Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux |journal=Cell |volume=83 |issue= 3 |pages= 463–72 |year= 1996 |pmid= 8521476 |doi=10.1016/0092-8674(95)90124-8 }}
*{{Cite journal | author=Kissinger CR, Parge HE, Knighton DR, ''et al.'' |title=Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex |journal=Nature |volume=378 |issue= 6557 |pages= 641–4 |year= 1996 |pmid= 8524402 |doi= 10.1038/378641a0 }}
*{{Cite journal | author=Wang MG, Yi H, Guerini D, ''et al.'' |title=Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively |journal=Cytogenet. Cell Genet. |volume=72 |issue= 2-3 |pages= 236–41 |year= 1997 |pmid= 8978785 |doi=10.1159/000134198 }}
*{{Cite journal | author=Shibasaki F, Kondo E, Akagi T, McKeon F |title=Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2 |journal=Nature |volume=386 |issue= 6626 |pages= 728–31 |year= 1997 |pmid= 9109491 |doi= 10.1038/386728a0 }}
*{{Cite journal | author=Kashishian A, Howard M, Loh C, ''et al.'' |title=AKAP79 inhibits calcineurin through a site distinct from the immunophilin-binding region |journal=J. Biol. Chem. |volume=273 |issue= 42 |pages= 27412–9 |year= 1998 |pmid= 9765270 |doi= 10.1074/jbc.273.42.27412}}
*{{Cite journal | author=Wang HG, Pathan N, Ethell IM, ''et al.'' |title=Ca2+-induced apoptosis through calcineurin dephosphorylation of BAD |journal=Science |volume=284 |issue= 5412 |pages= 339–43 |year= 1999 |pmid= 10195903 |doi= 10.1126/science.284.5412.339}}
*{{Cite journal | author=Fuentes JJ, Genescà L, Kingsbury TJ, ''et al.'' |title=DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways |journal=Hum. Mol. Genet. |volume=9 |issue= 11 |pages= 1681–90 |year= 2000 |pmid= 10861295 |doi= 10.1093/hmg/9.11.1681}}
*{{Cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}
*{{Cite journal | author=Frey N, Richardson JA, Olson EN |title=Calsarcins, a novel family of sarcomeric calcineurin-binding proteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14632–7 |year= 2001 |pmid= 11114196 |doi= 10.1073/pnas.260501097 | pmc=18970 }}
*{{Cite journal | author=Siddiq A, Miyazaki T, Takagishi Y, ''et al.'' |title=Expression of ZAKI-4 messenger ribonucleic acid in the brain during rat development and the effect of hypothyroidism |journal=Endocrinology |volume=142 |issue= 5 |pages= 1752–9 |year= 2001 |pmid= 11316738 |doi= 10.1210/en.142.5.1752}}
}}

{{Refend}}

==外部链接==
* {{MeshName|Calcineurin}}
* {{EMedicineDictionary|Calcineurin}}

{{PDB Gallery|geneid=5530}}
{{细胞内信号肽及信号蛋白}}
{{Phosphatases}}

[[分类:信号转导]]

[[分类:EC 3.1.3]]
==参考来源==
*[http://zh.wikipedia.org/wiki/%E9%92%99%E8%B0%83%E7%A3%B7%E9%85%B8%E9%85%B6 维基百科-钙调磷酸酶]

钙调磷酸酶 - 版本历史

14.36.39.47：建立内容为“{{PBB|geneid=5530}} '''钙调磷酸酶'''[http://www.term.gov.cn/pages/homepage/result2.jsp?id=332126&subid=10001798&subject=%E9%85%B6&subsys=%E7…”的新页面