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脂质过氧化 - 版本历史
2026-04-18T23:35:33Z
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2026年1月3日 (六) 00:22 77921020
2026-01-03T00:22:40Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2026年1月3日 (六) 00:22的版本</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l62" >第62行：</td>
<td colspan="2" class="diff-lineno">第62行：</td></tr>
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<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <table style="width: 100%<del class="diffchange diffchange-inline">; min-width: 600px</del>; border-collapse: collapse; border: 1.2px solid #cbd5e1; font-size: 0.95em; text-align: left;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <table style="width: 100%; border-collapse: collapse; border: 1.2px solid #cbd5e1; font-size: 0.95em; text-align: left;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr style="background-color: #f8fafc; border-bottom: 2px solid #0f172a;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr style="background-color: #f8fafc; border-bottom: 2px solid #0f172a;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: <del class="diffchange diffchange-inline">15</del>%; white-space: nowrap;">阶段</th></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: <ins class="diffchange diffchange-inline">20</ins>%; white-space: nowrap;">阶段</th></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af; width: <del class="diffchange diffchange-inline">50</del>%;">化学过程 <del class="diffchange diffchange-inline">(Mechanism)</del></th></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af; width: <ins class="diffchange diffchange-inline">40</ins>%;">化学过程</th></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569;">生物学描述</th></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569;">生物学描述</th></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">15px 12px</del>; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap<del class="diffchange diffchange-inline">; vertical-align: top</del>;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">10px</ins>; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap;">1. 引发 (Initiation)</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del>1. 引发<del class="diffchange diffchange-inline"><br><span style="font-weight:normal; font-size:0.85em; color:#64748b;"></del>(Initiation)<del class="diffchange diffchange-inline"></span></del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">10px</ins>; border: 1px solid #cbd5e1; font-family: <ins class="diffchange diffchange-inline">'Courier New', </ins>monospace; color: #334155;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del></td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>LH + R<sup>•</sup> → L<sup>•</sup> + RH</div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">15px 12px</del>; border: 1px solid #cbd5e1<del class="diffchange diffchange-inline">; vertical-align: top;"></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> <div style="background-color: #f1f5f9; border-radius: 6px; padding: 10px</del>; font-family: monospace<del class="diffchange diffchange-inline">; font-weight: bold</del>; color: #334155<del class="diffchange diffchange-inline">; border-left: 4px solid #b91c1c</del>;"></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del>LH + R<sup>•</sup> <del class="diffchange diffchange-inline">&nbsp;</del>→<del class="diffchange diffchange-inline">&nbsp; </del>L<sup>•</sup> + RH</div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </div></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> <div style="margin-top: 8px; font-size: 0.85em; color: #64748b;"></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> LH: 脂质分子 (如PUFA)<br></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> R<sup>•</sup>: 强自由基 (如羟自由基)</del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </div></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </td></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> <td style="padding: 15px 12px; border: 1px solid #cbd5e1; vertical-align: top;"></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> <strong>“窃氢”事件</strong><br></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> 强氧化剂从脂肪酸碳链上夺走一个氢原子，生成不稳定的<strong>脂质碳自由基 (L<sup>•</sup>)</strong>，启动灾难。</del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"> <td style="padding: 10px; border: 1px solid #cbd5e1;"><strong>“窃氢”</strong>：强氧化剂（如[[羟自由基]]）从不饱和脂肪酸 (LH) 上夺走一个氢原子，生成不稳定的脂质碳自由基 (L<sup>•</sup>)。</td></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">15px 12px</del>; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap<del class="diffchange diffchange-inline">; vertical-align: top</del>;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">10px</ins>; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap;">2. 传播 (Propagation)</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del>2. 传播<del class="diffchange diffchange-inline"><br><span style="font-weight:normal; font-size:0.85em; color:#64748b;"></del>(Propagation)<del class="diffchange diffchange-inline"></span></del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">10px</ins>; border: 1px solid #cbd5e1; font-family: <ins class="diffchange diffchange-inline">'Courier New', </ins>monospace; color: #334155;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del></td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>L<sup>•</sup> + O<sub>2</sub> → LOO<sup>•</sup><br></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">15px 12px</del>; border: 1px solid #cbd5e1<del class="diffchange diffchange-inline">; vertical-align: top;"></del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>LOO<sup>•</sup> + LH → L-OOH + L<sup>•</sup></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> <div style="background-color: #f1f5f9; border-radius: 6px; padding: 10px</del>; font-family: monospace<del class="diffchange diffchange-inline">; font-weight: bold</del>; color: #334155<del class="diffchange diffchange-inline">; border-left: 4px solid #1e40af; line-height: 1.8</del>;"></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> ① </del>L<sup>•</sup> + O<sub>2</sub> <del class="diffchange diffchange-inline">&nbsp;</del>→<del class="diffchange diffchange-inline">&nbsp; </del>LOO<sup>•</sup><br></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> ② </del>LOO<sup>•</sup> + LH <del class="diffchange diffchange-inline">&nbsp;</del>→<del class="diffchange diffchange-inline">&nbsp; </del>L-OOH + L<sup>•</sup></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </div></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> <div style="margin-top: 8px; font-size: 0.85em; color: #64748b;"></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> LOO<sup>•</sup>: 过氧自由基<br></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> L-OOH: 脂质过氧化物</del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </div></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </td></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> <td style="padding: 15px 12px; border: 1px solid #cbd5e1; vertical-align: top;"></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> <strong>“连锁反应”</strong><br></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> 新生成的自由基会攻击邻近的正常脂质，导致破坏呈指数级放大。步骤②中新产生的 L<sup>•</sup> 会再次进入步骤①。</del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"> <td style="padding: 10px; border: 1px solid #cbd5e1;"><strong>“连锁反应”</strong>：新生成的过氧自由基 (LOO<sup>•</sup>) 攻击邻近的脂质分子，导致自由基数量指数级扩增。</td></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">15px 12px</del>; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap<del class="diffchange diffchange-inline">; vertical-align: top</del>;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">10px</ins>; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap;">3. 终止 (Termination)</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del>3. 终止<del class="diffchange diffchange-inline"><br><span style="font-weight:normal; font-size:0.85em; color:#64748b;"></del>(Termination)<del class="diffchange diffchange-inline"></span></del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">10px</ins>; border: 1px solid #cbd5e1; font-family: <ins class="diffchange diffchange-inline">'Courier New', </ins>monospace; color: #334155;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del></td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>LOO<sup>•</sup> + Vit E → L-OOH + Vit E<sup>•</sup><br></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">15px 12px</del>; border: 1px solid #cbd5e1<del class="diffchange diffchange-inline">; vertical-align: top;"></del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>2 LOO<sup>•</sup> → <ins class="diffchange diffchange-inline">非自由基产物</ins></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> <div style="background-color: #f1f5f9; border-radius: 6px; padding: 10px</del>; font-family: monospace<del class="diffchange diffchange-inline">; font-weight: bold</del>; color: #334155<del class="diffchange diffchange-inline">; border-left: 4px solid #15803d; line-height: 1.8</del>;"></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del>LOO<sup>•</sup> + Vit E <del class="diffchange diffchange-inline">&nbsp;</del>→<del class="diffchange diffchange-inline">&nbsp; </del>L-OOH + Vit E<sup>•</sup><br></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del>2 LOO<sup>•</sup> <del class="diffchange diffchange-inline">&nbsp;</del>→<del class="diffchange diffchange-inline">&nbsp; 无活性产物</del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </div></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> <div style="margin-top: 8px; font-size: 0.85em; color: #64748b;"></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> Vit E<sup>•</sup>: 稳定的维生素E自由基</del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </div></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </td></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> <td style="padding: 15px 12px; border: 1px solid #cbd5e1; vertical-align: top;"></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> <strong>“及时止损”</strong><br></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> 抗氧化剂（如维生素E）提供电子中和自由基，将其转化为稳定的分子，打断链式反应。</del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;"> <td style="padding: 10px; border: 1px solid #cbd5e1;"><strong>“止损”</strong>：抗氧化剂（如[[维生素E]]）提供电子中和自由基，将其转化为无毒产物，打断链式反应。</td></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </table></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </table></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l160" >第160行：</td>
<td colspan="2" class="diff-lineno">第128行：</td></tr>
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<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="overflow-x: auto; margin: 30px auto; width: 100%;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="overflow-x: auto; margin: 30px auto; width: 100%;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <table style="width: 100%<del class="diffchange diffchange-inline">; min-width: 600px</del>; border-collapse: collapse; border: 1.2px solid #cbd5e1; font-size: 0.95em; text-align: left;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <table style="width: 100%; border-collapse: collapse; border: 1.2px solid #cbd5e1; font-size: 0.95em; text-align: left;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr style="background-color: #f8fafc; border-bottom: 2px solid #0f172a;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr style="background-color: #f8fafc; border-bottom: 2px solid #0f172a;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 25%; white-space: nowrap;">次级产物</th></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 25%; white-space: nowrap;">次级产物</th></div></td></tr>
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77921020
https://www.yiliao.com/index.php?title=%E8%84%82%E8%B4%A8%E8%BF%87%E6%B0%A7%E5%8C%96&diff=312419&oldid=prev
2026年1月3日 (六) 00:20 77921020
2026-01-03T00:20:35Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2026年1月3日 (六) 00:20的版本</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l64" >第64行：</td>
<td colspan="2" class="diff-lineno">第64行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <table style="width: 100%; min-width: 600px; border-collapse: collapse; border: 1.2px solid #cbd5e1; font-size: 0.95em; text-align: left;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <table style="width: 100%; min-width: 600px; border-collapse: collapse; border: 1.2px solid #cbd5e1; font-size: 0.95em; text-align: left;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr style="background-color: #f8fafc; border-bottom: 2px solid #0f172a;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr style="background-color: #f8fafc; border-bottom: 2px solid #0f172a;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: <del class="diffchange diffchange-inline">20</del>%; white-space: nowrap;">阶段 <del class="diffchange diffchange-inline">(Stage)</del></th></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: <ins class="diffchange diffchange-inline">15</ins>%; white-space: nowrap;">阶段</th></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af; width: <del class="diffchange diffchange-inline">45</del>%;">化学过程 (Mechanism)</th></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af; width: <ins class="diffchange diffchange-inline">50</ins>%;">化学过程 (Mechanism)</th></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569;">生物学描述</th></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569;">生物学描述</th></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 12px; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap; vertical-align: top;">1. 引发<br>(Initiation)</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">15px </ins>12px; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap; vertical-align: top;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 12px; border: 1px solid #cbd5e1; vertical-align: top;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>1. 引发<br<ins class="diffchange diffchange-inline">><span style="font-weight:normal; font-size:0.85em; color:#64748b;"</ins>>(Initiation)<ins class="diffchange diffchange-inline"></span></ins></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="<del class="diffchange diffchange-inline">margin</del>-<del class="diffchange diffchange-inline">bottom</del>: 6px; font-family: monospace; font-weight: bold; color: #334155;">LH + R<sup>•</sup> &nbsp;→&nbsp; L<sup>•</sup> + RH</div></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins></td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <<del class="diffchange diffchange-inline">span </del>style="font-size:0.85em; color:#64748b;"><del class="diffchange diffchange-inline">(</del>LH<del class="diffchange diffchange-inline">=</del>脂质分子<del class="diffchange diffchange-inline">, </del>R<sup>•</sup>=<del class="diffchange diffchange-inline">自由基</del>)</<del class="diffchange diffchange-inline">span</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">15px </ins>12px; border: 1px solid #cbd5e1; vertical-align: top;"></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="<ins class="diffchange diffchange-inline">background-color: #f1f5f9; border</ins>-<ins class="diffchange diffchange-inline">radius</ins>: 6px<ins class="diffchange diffchange-inline">; padding: 10px</ins>; font-family: monospace; font-weight: bold; color: #334155<ins class="diffchange diffchange-inline">; border-left: 4px solid #b91c1c</ins>;"></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>LH + R<sup>•</sup> &nbsp;→&nbsp; L<sup>•</sup> + RH</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins></div></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <<ins class="diffchange diffchange-inline">div </ins>style="<ins class="diffchange diffchange-inline">margin-top: 8px; </ins>font-size: 0.85em; color: #64748b;"></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>LH<ins class="diffchange diffchange-inline">: </ins>脂质分子 <ins class="diffchange diffchange-inline">(如PUFA)<br></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>R<sup>•</sup><ins class="diffchange diffchange-inline">: 强自由基 (如羟自由基)</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </div></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </td></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <td style</ins>=<ins class="diffchange diffchange-inline">"padding: 15px 12px; border: 1px solid #cbd5e1; vertical-align: top;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <strong>“窃氢”事件</strong><br></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> 强氧化剂从脂肪酸碳链上夺走一个氢原子，生成不稳定的<strong>脂质碳自由基 (L<sup>•</sup></ins>)</<ins class="diffchange diffchange-inline">strong</ins>><ins class="diffchange diffchange-inline">，启动灾难。</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"> <td style="padding: 12px; border: 1px solid #cbd5e1; vertical-align: top;"><strong>“窃氢”</strong>：强氧化剂（如[[羟自由基]]）从不饱和脂肪酸的碳链上夺走一个氢原子，生成不稳定的<strong>脂质碳自由基 (L<sup>•</sup>)</strong>。</td></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 12px; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap; vertical-align: top;">2. 传播<br>(Propagation)</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">15px </ins>12px; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap; vertical-align: top;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 12px; border: 1px solid #cbd5e1; vertical-align: top;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>2. 传播<br<ins class="diffchange diffchange-inline">><span style="font-weight:normal; font-size:0.85em; color:#64748b;"</ins>>(Propagation)<ins class="diffchange diffchange-inline"></span></ins></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="<del class="diffchange diffchange-inline">margin</del>-<del class="diffchange diffchange-inline">bottom</del>: 6px; font-family: monospace; font-weight: bold; color: #334155;">L<sup>•</sup> + O<sub>2</sub> &nbsp;→&nbsp; LOO<sup>•</sup><<del class="diffchange diffchange-inline">/div</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins></td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> <div style="margin-bottom: 6px; font-family: monospace; font-weight: bold; color: #334155;"></del>LOO<sup>•</sup> + LH &nbsp;→&nbsp; L-OOH + L<sup>•</sup></div></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">15px </ins>12px; border: 1px solid #cbd5e1; vertical-align: top;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <<del class="diffchange diffchange-inline">span </del>style="font-size:0.85em; color:#64748b;"><del class="diffchange diffchange-inline">(</del>LOO<sup>•</sup><del class="diffchange diffchange-inline">=</del>过氧自由基<del class="diffchange diffchange-inline">, </del>L-OOH=<del class="diffchange diffchange-inline">脂质过氧化物)</del></<del class="diffchange diffchange-inline">span</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="<ins class="diffchange diffchange-inline">background-color: #f1f5f9; border</ins>-<ins class="diffchange diffchange-inline">radius</ins>: 6px<ins class="diffchange diffchange-inline">; padding: 10px</ins>; font-family: monospace; font-weight: bold; color: #334155<ins class="diffchange diffchange-inline">; border-left: 4px solid #1e40af; line-height: 1.8</ins>;"></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> ① </ins>L<sup>•</sup> + O<sub>2</sub> &nbsp;→&nbsp; LOO<sup>•</sup><<ins class="diffchange diffchange-inline">br</ins>></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> ② </ins>LOO<sup>•</sup> + LH &nbsp;→&nbsp; L-OOH + L<sup>•</sup></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins></div></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <<ins class="diffchange diffchange-inline">div </ins>style="<ins class="diffchange diffchange-inline">margin-top: 8px; </ins>font-size: 0.85em; color: #64748b;"></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>LOO<sup>•</sup><ins class="diffchange diffchange-inline">: </ins>过氧自由基<ins class="diffchange diffchange-inline"><br></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>L-OOH<ins class="diffchange diffchange-inline">: 脂质过氧化物</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </div></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </td></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <td style</ins>=<ins class="diffchange diffchange-inline">"padding: 15px 12px; border: 1px solid #cbd5e1; vertical-align: top;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <strong>“连锁反应”</strong><br></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> 新生成的自由基会攻击邻近的正常脂质，导致破坏呈指数级放大。步骤②中新产生的 L<sup>•</ins></<ins class="diffchange diffchange-inline">sup</ins>> <ins class="diffchange diffchange-inline">会再次进入步骤①。</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"> <td style="padding: 12px; border: 1px solid #cbd5e1; vertical-align: top;"><strong>“连锁反应”</strong>：L<sup>•</sup> 迅速与氧气反应生成过氧自由基，后者再去攻击邻近的脂质分子夺氢。这导致一个自由基可以破坏成百上千个脂质分子。</td></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 12px; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap; vertical-align: top;">3. 终止<br>(Termination)</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">15px </ins>12px; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap; vertical-align: top;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: 12px; border: 1px solid #cbd5e1; vertical-align: top;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>3. 终止<br<ins class="diffchange diffchange-inline">><span style="font-weight:normal; font-size:0.85em; color:#64748b;"</ins>>(Termination)<ins class="diffchange diffchange-inline"></span></ins></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="<del class="diffchange diffchange-inline">margin</del>-<del class="diffchange diffchange-inline">bottom</del>: 6px; font-family: monospace; font-weight: bold; color: #334155;">LOO<sup>•</sup> + Vit E &nbsp;→&nbsp; L-OOH + Vit E<sup>•</sup></div></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins></td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin-<del class="diffchange diffchange-inline">bottom</del>: <del class="diffchange diffchange-inline">6px</del>; font-<del class="diffchange diffchange-inline">family</del>: <del class="diffchange diffchange-inline">monospace; font-weight: bold</del>; color: #<del class="diffchange diffchange-inline">334155</del>;"><del class="diffchange diffchange-inline">2 LOO</del><sup>•</sup> <del class="diffchange diffchange-inline">&nbsp</del>;<del class="diffchange diffchange-inline">→&nbsp</del>; <del class="diffchange diffchange-inline">非自由基产物</del></<del class="diffchange diffchange-inline">div</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">15px </ins>12px; border: 1px solid #cbd5e1; vertical-align: top;"></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="<ins class="diffchange diffchange-inline">background-color: #f1f5f9; border</ins>-<ins class="diffchange diffchange-inline">radius</ins>: 6px<ins class="diffchange diffchange-inline">; padding: 10px</ins>; font-family: monospace; font-weight: bold; color: #334155<ins class="diffchange diffchange-inline">; border-left: 4px solid #15803d; line-height: 1.8</ins>;"></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins>LOO<sup>•</sup> + Vit E &nbsp;→&nbsp; L-OOH + Vit E<sup>•</sup><ins class="diffchange diffchange-inline"><br></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> 2 LOO<sup>•</sup> &nbsp;→&nbsp; 无活性产物</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins></div></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin-<ins class="diffchange diffchange-inline">top</ins>: <ins class="diffchange diffchange-inline">8px</ins>; font-<ins class="diffchange diffchange-inline">size</ins>: <ins class="diffchange diffchange-inline">0.85em</ins>; color: #<ins class="diffchange diffchange-inline">64748b</ins>;"></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> Vit E</ins><sup>•</sup><ins class="diffchange diffchange-inline">: 稳定的维生素E自由基</ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </div></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </td></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <td style="padding: 15px 12px; border: 1px solid #cbd5e1</ins>; <ins class="diffchange diffchange-inline">vertical-align: top</ins>;<ins class="diffchange diffchange-inline">"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <strong>“及时止损”</ins></<ins class="diffchange diffchange-inline">strong><br</ins>></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> 抗氧化剂（如维生素E）提供电子中和自由基，将其转化为稳定的分子，打断链式反应。</ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"> <td style="padding: 12px; border: 1px solid #cbd5e1; vertical-align: top;"><strong>“止损”</strong>：抗氧化剂（如[[维生素E]]、[[FSP1]]/CoQ10系统）提供电子中和自由基，打断链式反应。</td></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </table></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </table></div></td></tr>
</table>
77921020
https://www.yiliao.com/index.php?title=%E8%84%82%E8%B4%A8%E8%BF%87%E6%B0%A7%E5%8C%96&diff=312418&oldid=prev
2026年1月3日 (六) 00:18 77921020
2026-01-03T00:18:34Z
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<table class="diff diff-contentalign-left diff-editfont-monospace" data-mw="interface">
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2026年1月3日 (六) 00:18的版本</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l65" >第65行：</td>
<td colspan="2" class="diff-lineno">第65行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr style="background-color: #f8fafc; border-bottom: 2px solid #0f172a;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr style="background-color: #f8fafc; border-bottom: 2px solid #0f172a;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 20%; white-space: nowrap;">阶段 (Stage)</th></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 20%; white-space: nowrap;">阶段 (Stage)</th></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af; width: <del class="diffchange diffchange-inline">40</del>%;">化学过程</th></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af; width: <ins class="diffchange diffchange-inline">45</ins>%;">化学过程 <ins class="diffchange diffchange-inline">(Mechanism)</ins></th></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569;">生物学描述</th></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569;">生物学描述</th></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">10px</del>; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap;">1. 引发 (Initiation)</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">12px</ins>; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap<ins class="diffchange diffchange-inline">; vertical-align: top</ins>;">1. 引发<ins class="diffchange diffchange-inline"><br></ins>(Initiation)</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">10px</del>; border: 1px solid #cbd5e1;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">12px</ins>; border: 1px solid #cbd5e1<ins class="diffchange diffchange-inline">; vertical-align: top</ins>;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> LH + R<sup>•</sup> → <del class="diffchange diffchange-inline"><strong></del>L<sup>•</sup></<del class="diffchange diffchange-inline">strong</del>> <del class="diffchange diffchange-inline">+ RH</del></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <ins class="diffchange diffchange-inline"><div style="margin-bottom: 6px; font-family: monospace; font-weight: bold; color: #334155;"></ins>LH + R<sup>•</sup> <ins class="diffchange diffchange-inline">&nbsp;</ins>→<ins class="diffchange diffchange-inline">&nbsp; </ins>L<sup>•</sup> <ins class="diffchange diffchange-inline">+ RH</ins></<ins class="diffchange diffchange-inline">div</ins>></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <del class="diffchange diffchange-inline"><br></del><span style="font-size:0.<del class="diffchange diffchange-inline">9em</del>; color:#64748b;">(LH=<del class="diffchange diffchange-inline">脂质</del>, <del class="diffchange diffchange-inline">R•</del>=<del class="diffchange diffchange-inline">ROS</del>)</span></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <span style="font-size:0.<ins class="diffchange diffchange-inline">85em</ins>; color:#64748b;">(LH=<ins class="diffchange diffchange-inline">脂质分子</ins>, <ins class="diffchange diffchange-inline">R<sup>•</sup></ins>=<ins class="diffchange diffchange-inline">自由基</ins>)</span></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">10px</del>; border: 1px solid #cbd5e1;"><strong>“窃氢”</strong>：强氧化剂（如[[羟自由基]]）从不饱和脂肪酸的碳链上夺走一个氢原子，生成不稳定的<strong>脂质碳自由基 (L<sup>•</sup>)</strong>。</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">12px</ins>; border: 1px solid #cbd5e1<ins class="diffchange diffchange-inline">; vertical-align: top</ins>;"><strong>“窃氢”</strong>：强氧化剂（如[[羟自由基]]）从不饱和脂肪酸的碳链上夺走一个氢原子，生成不稳定的<strong>脂质碳自由基 (L<sup>•</sup>)</strong>。</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">10px</del>; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap;">2. 传播 (Propagation)</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">12px</ins>; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap<ins class="diffchange diffchange-inline">; vertical-align: top</ins>;">2. 传播<ins class="diffchange diffchange-inline"><br></ins>(Propagation)</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">10px</del>; border: 1px solid #cbd5e1;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">12px</ins>; border: 1px solid #cbd5e1<ins class="diffchange diffchange-inline">; vertical-align: top</ins>;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> L<sup>•</sup> + O<sub>2</sub> → <del class="diffchange diffchange-inline"><strong></del>LOO<sup>•</sup></<del class="diffchange diffchange-inline">strong</del>> <del class="diffchange diffchange-inline">(脂质过氧自由基)</del><<del class="diffchange diffchange-inline">br</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <ins class="diffchange diffchange-inline"><div style="margin-bottom: 6px; font-family: monospace; font-weight: bold; color: #334155;"></ins>L<sup>•</sup> + O<sub>2</sub> <ins class="diffchange diffchange-inline">&nbsp;</ins>→<ins class="diffchange diffchange-inline">&nbsp; </ins>LOO<sup>•</sup></<ins class="diffchange diffchange-inline">div</ins>></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline"> </del>LOO<sup>•</sup> + LH → <del class="diffchange diffchange-inline"><strong></del>L-OOH</<del class="diffchange diffchange-inline">strong</del>> <del class="diffchange diffchange-inline">+ L</del><sup>•</sup></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ins><<ins class="diffchange diffchange-inline">div style="margin-bottom: 6px; font-family: monospace; font-weight: bold; color: #334155;"</ins>>LOO<sup>•</sup> + LH <ins class="diffchange diffchange-inline">&nbsp;</ins>→<ins class="diffchange diffchange-inline">&nbsp; </ins>L-OOH <ins class="diffchange diffchange-inline">+ L<sup>•</ins></<ins class="diffchange diffchange-inline">sup</ins>><ins class="diffchange diffchange-inline"></div></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <span style="font-size:0.85em; color:#64748b;">(LOO</ins><sup>•</sup<ins class="diffchange diffchange-inline">>=过氧自由基, L-OOH=脂质过氧化物)</span</ins>></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">10px</del>; border: 1px solid #cbd5e1;"><strong>“连锁反应”</strong>：L<sup>•</sup> 迅速与氧气反应生成过氧自由基，后者再去攻击邻近的脂质分子夺氢。这导致一个自由基可以破坏成百上千个脂质分子。</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">12px</ins>; border: 1px solid #cbd5e1<ins class="diffchange diffchange-inline">; vertical-align: top</ins>;"><strong>“连锁反应”</strong>：L<sup>•</sup> 迅速与氧气反应生成过氧自由基，后者再去攻击邻近的脂质分子夺氢。这导致一个自由基可以破坏成百上千个脂质分子。</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <tr></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">10px</del>; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap;">3. 终止 (Termination)</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">12px</ins>; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap<ins class="diffchange diffchange-inline">; vertical-align: top</ins>;">3. 终止<ins class="diffchange diffchange-inline"><br></ins>(Termination)</td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">10px</del>; border: 1px solid #cbd5e1;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">12px</ins>; border: 1px solid #cbd5e1<ins class="diffchange diffchange-inline">; vertical-align: top</ins>;"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> LOO<sup>•</sup> + Vit E → L-OOH + Vit E<sup>•</sup><<del class="diffchange diffchange-inline">br</del>></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <ins class="diffchange diffchange-inline"><div style="margin-bottom: 6px; font-family: monospace; font-weight: bold; color: #334155;"></ins>LOO<sup>•</sup> + Vit E <ins class="diffchange diffchange-inline">&nbsp;</ins>→<ins class="diffchange diffchange-inline">&nbsp; </ins>L-OOH + Vit E<sup>•</sup><<ins class="diffchange diffchange-inline">/div</ins>></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> 2 LOO<sup>•</sup> → 非自由基产物</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <ins class="diffchange diffchange-inline"><div style="margin-bottom: 6px; font-family: monospace; font-weight: bold; color: #334155;"></ins>2 LOO<sup>•</sup> <ins class="diffchange diffchange-inline">&nbsp;</ins>→<ins class="diffchange diffchange-inline">&nbsp; </ins>非自由基产物<ins class="diffchange diffchange-inline"></div></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </td></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <del class="diffchange diffchange-inline">10px</del>; border: 1px solid #cbd5e1;"><strong>“止损”</strong>：抗氧化剂（如[[维生素E]]、[[FSP1]]/CoQ10系统）提供电子中和自由基，打断链式反应。</td></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <td style="padding: <ins class="diffchange diffchange-inline">12px</ins>; border: 1px solid #cbd5e1<ins class="diffchange diffchange-inline">; vertical-align: top</ins>;"><strong>“止损”</strong>：抗氧化剂（如[[维生素E]]、[[FSP1]]/CoQ10系统）提供电子中和自由基，打断链式反应。</td></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </tr></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </table></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </table></div></td></tr>
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77921020
https://www.yiliao.com/index.php?title=%E8%84%82%E8%B4%A8%E8%BF%87%E6%B0%A7%E5%8C%96&diff=312417&oldid=prev
77921020：建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面
2026-01-03T00:16:40Z
<p>建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面</p>
<p><b>新页面</b></p><div><div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff; max-width: 1200px; margin: auto;"><br />
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<strong>脂质过氧化</strong>（Lipid Peroxidation）是指氧化剂（如<strong>[[自由基]]</strong>）攻击脂质中的不饱和脂肪酸，夺取电子并产生过氧化物的过程。这是一种破坏性的<strong>链式反应</strong>，主要发生在细胞膜、线粒体膜等富含<strong>[[多不饱和脂肪酸]]</strong> (PUFA) 的结构上。该过程不仅直接破坏膜的完整性和流动性，导致细胞破裂，其次级产物（如 <strong>[[4-HNE]]</strong> 和 <strong>[[MDA]]</strong>）还具有强烈的细胞毒性，能与蛋白质和 DNA 形成加合物，诱发突变。在现代医学中，脂质过氧化被确认为<strong>[[铁死亡]]</strong> (Ferroptosis) 的核心致死机制，同时也是<strong>[[动脉粥样硬化]]</strong>和<strong>[[缺血再灌注损伤]]</strong>的关键病理基础。<br />
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<div style="font-size: 1.2em; font-weight: bold; letter-spacing: 1.2px;">脂质过氧化</div><br />
<div style="font-size: 0.7em; opacity: 0.85; margin-top: 4px; white-space: nowrap;">Lipid Peroxidation (点击展开)</div><br />
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[[Image:Lipid_Peroxidation_Chain_Reaction.png|100px|自由基攻击细胞膜脂质]]<br />
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<div style="font-size: 0.8em; color: #64748b; margin-top: 12px; font-weight: 600;">细胞膜的“燃烧”</div><br />
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<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">自由基链式反应</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; white-space: nowrap;">主要底物</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">[[PUFA]] (花生四烯酸等)</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; white-space: nowrap;">引发剂</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;">[[羟自由基]] (OH<sup>•</sup>), [[LOX酶]]</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; white-space: nowrap;">初级产物</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">脂质氢过氧化物 (L-OOH)</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; white-space: nowrap;">次级毒物</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #b91c1c;">[[MDA]], [[4-HNE]], [[丙烯醛]]</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; white-space: nowrap;">天然抑制剂</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #15803d;">[[维生素E]], [[GPX4]]</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; white-space: nowrap;">检测指标</th><br />
<td style="padding: 6px 12px; color: #1e40af;">TBARS, C11-BODIPY</td><br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">反应机制：死亡的多米诺骨牌</h2><br />
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脂质过氧化是一个自我放大的循环过程，通常分为三个阶段：引发、传播和终止。<br />
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<th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 20%; white-space: nowrap;">阶段 (Stage)</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af; width: 40%;">化学过程</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569;">生物学描述</th><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap;">1. 引发 (Initiation)</td><br />
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LH + R<sup>•</sup> → <strong>L<sup>•</sup></strong> + RH<br />
<br><span style="font-size:0.9em; color:#64748b;">(LH=脂质, R•=ROS)</span><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1;"><strong>“窃氢”</strong>：强氧化剂（如[[羟自由基]]）从不饱和脂肪酸的碳链上夺走一个氢原子，生成不稳定的<strong>脂质碳自由基 (L<sup>•</sup>)</strong>。</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap;">2. 传播 (Propagation)</td><br />
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L<sup>•</sup> + O<sub>2</sub> → <strong>LOO<sup>•</sup></strong> (脂质过氧自由基)<br><br />
LOO<sup>•</sup> + LH → <strong>L-OOH</strong> + L<sup>•</sup><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1;"><strong>“连锁反应”</strong>：L<sup>•</sup> 迅速与氧气反应生成过氧自由基，后者再去攻击邻近的脂质分子夺氢。这导致一个自由基可以破坏成百上千个脂质分子。</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap;">3. 终止 (Termination)</td><br />
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LOO<sup>•</sup> + Vit E → L-OOH + Vit E<sup>•</sup><br><br />
2 LOO<sup>•</sup> → 非自由基产物<br />
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<td style="padding: 10px; border: 1px solid #cbd5e1;"><strong>“止损”</strong>：抗氧化剂（如[[维生素E]]、[[FSP1]]/CoQ10系统）提供电子中和自由基，打断链式反应。</td><br />
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[[Image:Lipid_Peroxidation_Steps.png|100px|引发-传播-终止三步曲]]<br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">两条关键路径：酶促与非酶促</h2><br />
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脂质过氧化并不总是随机的破坏，它也可以是受控的信号过程。<br />
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<h3 style="margin-top: 0; color: #b91c1c; font-size: 1.1em; border-bottom: 2px solid #fecaca; padding-bottom: 10px;">非酶促氧化 (ROS驱动)</h3><br />
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<strong>驱动力：</strong> [[芬顿反应]]产生的高毒性 [[羟自由基]]。<br />
<br><strong>特征：</strong> 随机攻击，不可控，破坏性强。<br />
<br><strong>后果：</strong> 膜破裂，产生大量有毒醛类（4-HNE），是<strong>[[铁死亡]]</strong>和组织损伤（如心梗）的主要原因。<br />
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<h3 style="margin-top: 0; color: #0f766e; font-size: 1.1em; border-bottom: 2px solid #ccfbf1; padding-bottom: 10px;">酶促氧化 (LOX驱动)</h3><br />
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<strong>驱动力：</strong> <strong>[[脂氧合酶]]</strong> (ALOX, 如 15-LOX)。<br />
<br><strong>特征：</strong> 特异性氧化特定的 PUFA（如花生四烯酸），受细胞信号调控。<br />
<br><strong>后果：</strong> 生成生理性信号分子（如白三烯、脂氧素），参与<strong>[[炎症]]</strong>调控；但在特定条件下也会促进铁死亡。<br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">有毒产物：不仅是膜损伤</h2><br />
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脂质过氧化的危害不仅在于“烧穿”细胞膜，其分解产生的活性醛类（Reactive Aldehydes）作为“第二信使”，能扩散到远处造成更持久的伤害。<br />
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<th style="padding: 12px; border: 1px solid #cbd5e1; color: #0f172a; width: 25%; white-space: nowrap;">次级产物</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #1e40af; width: 40%;">特性与机制</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569;">病理影响</th><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap;">4-HNE<br>(4-羟基壬烯醛)</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">最具生物活性的醛。具有亲电性，易与蛋白质的组氨酸/半胱氨酸残基发生 Michael 加成。</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">导致酶失活（如抑制线粒体酶）、诱导细胞凋亡，与<strong>[[阿尔茨海默病]]</strong>和糖尿病有关。</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap;">MDA<br>(丙二醛)</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">最常用的氧化应激标志物。能与 DNA 形成加合物（MDA-DNA Adducts）。</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">具有<strong>致突变性</strong>，长期积累可导致癌症发生。</td><br />
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<td style="padding: 10px; border: 1px solid #cbd5e1; font-weight: 600; white-space: nowrap;">OxLDL<br>(氧化低密度脂蛋白)</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">LDL 颗粒表面的脂质被氧化后，无法被正常受体识别，而被巨噬细胞吞噬。</td><br />
<td style="padding: 10px; border: 1px solid #cbd5e1;">形成<strong>泡沫细胞</strong>，是<strong>[[动脉粥样硬化]]</strong>斑块形成的始动因素。</td><br />
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<span style="color: #0f172a; font-weight: bold; font-size: 1.05em; display: inline-block; margin-bottom: 15px;">学术参考文献与权威点评</span><br />
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[1] <strong>Esterbauer H, et al. (1991).</strong> <em>Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes.</em> <strong>[[Free Radical Biology and Medicine]]</strong>. 1991;11(1):81-128.<br><br />
<span style="color: #475569;">[学术点评]：经典综述。这篇被引用数千次的文章奠定了脂质过氧化次级产物（特别是 4-HNE）作为“毒性第二信使”的理论基础。</span><br />
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[2] <strong>Stockwell BR, et al. (2017).</strong> <em>Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease.</em> <strong>[[Cell]]</strong>. 2017;171(2):273-285.<br><br />
<span style="color: #475569;">[学术点评]：机制链接。明确了脂质过氧化是铁死亡的执行步骤，而 GPX4 是防止这一过程的关键酶，将古老的氧化理论与新型细胞死亡联系起来。</span><br />
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[3] <strong>Yin H, Xu L, Porter NA. (2011).</strong> <em>Free radical lipid peroxidation: mechanisms and analysis.</em> <strong>[[Chemical Reviews]]</strong>. 2011;111(10):5944-5972.<br><br />
<span style="color: #475569;">[学术点评]：化学机理。深入解析了脂质过氧化的详细化学反应动力学，以及不同脂质过氧化物的检测方法（如质谱分析）。</span><br />
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脂质过氧化 · 知识图谱<br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">关键底物</td><br />
<td style="padding: 10px 15px; color: #334155;">[[PUFA]] (花生四烯酸/亚油酸) • [[磷脂]] (PE)</td><br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">防御系统</td><br />
<td style="padding: 10px 15px; color: #334155;">[[GPX4]] (酶) • [[维生素E]] (非酶) • [[CoQ10]]</td><br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">产物危害</td><br />
<td style="padding: 10px 15px; color: #334155;">[[膜流动性]]降低 • [[DNA加合物]] • [[蛋白质交联]]</td><br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">相关疾病</td><br />
<td style="padding: 10px 15px; color: #334155;">[[铁死亡]] (癌症) • [[动脉粥样硬化]] • [[阿尔茨海默病]]</td><br />
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