https://www.yiliao.com/index.php?action=history&feed=atom&title=%E7%BB%86%E8%83%9E%E5%A2%9E%E6%AE%96
细胞增殖 - 版本历史
2026-04-19T05:09:17Z
本wiki的该页面的版本历史
MediaWiki 1.35.1
https://www.yiliao.com/index.php?title=%E7%BB%86%E8%83%9E%E5%A2%9E%E6%AE%96&diff=311301&oldid=prev
2025年12月29日 (一) 02:18 223.160.136.32
2025-12-29T02:18:27Z
<p></p>
<table class="diff diff-contentalign-left diff-editfont-monospace" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="zh-Hans-CN">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2025年12月29日 (一) 02:18的版本</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l40" >第40行：</td>
<td colspan="2" class="diff-lineno">第40行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><h2 style="background: linear-gradient(to right, #1e3a8a, #ffffff); color: #ffffff; padding: 8px 15px; border-radius: 4px; font-size: 1.2em; margin-top: 35px; text-decoration: none !important;">细胞周期的精密调控</h2></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><h2 style="background: linear-gradient(to right, #1e3a8a, #ffffff); color: #ffffff; padding: 8px 15px; border-radius: 4px; font-size: 1.2em; margin-top: 35px; text-decoration: none !important;">细胞周期的精密调控</h2></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[Image of the cell cycle phases]</del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p style="margin: 15px 0;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><p style="margin: 15px 0;"></div></td></tr>
</table>
223.160.136.32
https://www.yiliao.com/index.php?title=%E7%BB%86%E8%83%9E%E5%A2%9E%E6%AE%96&diff=311300&oldid=prev
2025年12月29日 (一) 02:18 223.160.136.32
2025-12-29T02:18:05Z
<p></p>
<table class="diff diff-contentalign-left diff-editfont-monospace" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="zh-Hans-CN">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2025年12月29日 (一) 02:18的版本</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l17" >第17行：</td>
<td colspan="2" class="diff-lineno">第17行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="padding: 35px; text-align: center; background-color: #f8fafc;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="padding: 35px; text-align: center; background-color: #f8fafc;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="display: inline-block; background: #ffffff; border: 1px solid #e2e8f0; border-radius: 20px; padding: 25px; box-shadow: 0 4px 10px rgba(0,0,0,0.03);"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="display: inline-block; background: #ffffff; border: 1px solid #e2e8f0; border-radius: 20px; padding: 25px; box-shadow: 0 4px 10px rgba(0,0,0,0.03);"></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> [[文件:Cell_Cycle_Proliferation_Icon.png|110px|细胞周期与增殖示意图]]</div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> [[文件:Cell_Cycle_Proliferation_Icon.png|110px|细胞周期与增殖示意图<ins class="diffchange diffchange-inline">|链接=Special:FilePath/Cell_Cycle_Proliferation_Icon.png</ins>]]</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="font-size: 0.85em; color: #64748b; margin-top: 15px; font-weight: 600;">细胞周期各阶段时相模型</div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="font-size: 0.85em; color: #64748b; margin-top: 15px; font-weight: 600;">细胞周期各阶段时相模型</div></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l52" >第52行：</td>
<td colspan="2" class="diff-lineno">第52行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 10px;"><strong>调控轴心：</strong> 细胞周期蛋白依赖性激酶（[[CDKs]]）与周期蛋白（[[Cyclins]]）的复合物是驱动周期的引擎，而 [[p53]]、p21 等抑癌蛋白则负责在 DNA 受损时制动周期。</li></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <li style="margin-bottom: 10px;"><strong>调控轴心：</strong> 细胞周期蛋白依赖性激酶（[[CDKs]]）与周期蛋白（[[Cyclins]]）的复合物是驱动周期的引擎，而 [[p53]]、p21 等抑癌蛋白则负责在 DNA 受损时制动周期。</li></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></ul></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div></ul></div></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">[Image of the cell cycle checkpoints]</del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;"></del></div></td><td colspan="2"> </td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><h2 style="background: linear-gradient(to right, #1e3a8a, #ffffff); color: #ffffff; padding: 8px 15px; border-radius: 4px; font-size: 1.2em; margin-top: 35px; text-decoration: none !important;">临床病理与细胞工程中的增殖</h2></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><h2 style="background: linear-gradient(to right, #1e3a8a, #ffffff); color: #ffffff; padding: 8px 15px; border-radius: 4px; font-size: 1.2em; margin-top: 35px; text-decoration: none !important;">临床病理与细胞工程中的增殖</h2></div></td></tr>
</table>
223.160.136.32
https://www.yiliao.com/index.php?title=%E7%BB%86%E8%83%9E%E5%A2%9E%E6%AE%96&diff=311299&oldid=prev
223.160.136.32：建立内容为“<div style="padding: 0 2%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面
2025-12-29T02:17:31Z
<p>建立内容为“<div style="padding: 0 2%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面</p>
<p><b>新页面</b></p><div><div style="padding: 0 2%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff;"><br />
<br />
<div style="margin-bottom: 20px; border-bottom: 1px solid #f1f5f9; padding-bottom: 15px;"><br />
<p style="font-size: 1.1em; margin: 10px 0; color: #334155;"><br />
<strong>细胞增殖</strong>（Cell Proliferation）是指细胞通过[[细胞分裂]]（主要是[[有丝分裂]]）增加数量的过程。该过程受严密的细胞周期（Cell Cycle）逻辑控制，涉及 DNA 复制、细胞器倍增及物质分配。在生理状态下，增殖与[[细胞凋亡]]保持动态平衡；在病理状态下，增殖失控是[[恶性肿瘤]]的标志性特征，而受控的体外增殖则是[[生物治疗]]产品生产的核心环节。<br />
</p><br />
</div><br />
<br />
<div class="medical-infobox mw-collapsible" style="width: 100%; max-width: 340px; margin: 0 auto 30px auto; border: 1px solid #cbd5e1; border-radius: 12px; background-color: #ffffff; box-shadow: 0 10px 25px rgba(0,0,0,0.08); overflow: hidden;"><br />
<br />
<div style="padding: 18px 15px; color: #ffffff; background: linear-gradient(135deg, #1e3a8a 0%, #3b82f6 100%); text-align: center; cursor: pointer;"><br />
<div style="font-size: 1.25em; font-weight: bold; letter-spacing: 1px; text-decoration: none !important;">细胞增殖 · 生命律动</div><br />
<div style="font-size: 0.75em; opacity: 0.8; margin-top: 4px; white-space: nowrap; text-decoration: none !important;">Cell Proliferation (点击展开)</div><br />
</div><br />
<br />
<div class="mw-collapsible-content"><br />
<div style="padding: 35px; text-align: center; background-color: #f8fafc;"><br />
<div style="display: inline-block; background: #ffffff; border: 1px solid #e2e8f0; border-radius: 20px; padding: 25px; box-shadow: 0 4px 10px rgba(0,0,0,0.03);"><br />
[[文件:Cell_Cycle_Proliferation_Icon.png|110px|细胞周期与增殖示意图]]<br />
</div><br />
<div style="font-size: 0.85em; color: #64748b; margin-top: 15px; font-weight: 600;">细胞周期各阶段时相模型</div><br />
</div><br />
<br />
<table style="width: 100%; border-spacing: 0; border-collapse: collapse; font-size: 0.9em;"><br />
<tr><br />
<th style="text-align: left; padding: 10px 18px; border-bottom: 1px solid #f1f5f9; color: #64748b; font-weight: 600; width: 40%; background-color: #fcfdfe;">主要阶段</th><br />
<td style="padding: 10px 18px; border-bottom: 1px solid #f1f5f9; color: #1e293b;">$G_1 \to S \to G_2 \to M$</td><br />
</tr><br />
<tr><br />
<th style="text-align: left; padding: 10px 18px; border-bottom: 1px solid #f1f5f9; color: #64748b; font-weight: 600; background-color: #fcfdfe;">核心调控</th><br />
<td style="padding: 10px 18px; border-bottom: 1px solid #f1f5f9; color: #1e293b;">[[CDKs]] / [[Cyclins]]</td><br />
</tr><br />
<tr><br />
<th style="text-align: left; padding: 10px 18px; color: #64748b; font-weight: 600; background-color: #fcfdfe;">检测标志物</th><br />
<td style="padding: 10px 18px; color: #1e293b; font-weight: bold;">Ki-67, PCNA, EdU</td><br />
</tr><br />
</table><br />
</div><br />
</div><br />
<br />
<h2 style="background: linear-gradient(to right, #1e3a8a, #ffffff); color: #ffffff; padding: 8px 15px; border-radius: 4px; font-size: 1.2em; margin-top: 35px; text-decoration: none !important;">细胞周期的精密调控</h2><br />
<br />
<br />
[Image of the cell cycle phases]<br />
<br />
<p style="margin: 15px 0;"><br />
细胞增殖通过一系列有序的时相完成，每个环节均由特定的信号通路和检查点（Checkpoints）监控：<br />
</p><br />
<ul style="padding-left: 20px; color: #475569;"><br />
<li style="margin-bottom: 10px;"><strong>间期 (Interphase)：</strong> 包括 $G_1$ 期（蛋白质与 RNA 合成）、$S$ 期（[[DNA 复制]]）和 $G_2$ 期（准备分裂所需能量与物质）。</li><br />
<li style="margin-bottom: 10px;"><strong>分裂期 (M Phase)：</strong> 染色体高度浓缩并精确分配至两个子细胞中。</li><br />
<li style="margin-bottom: 10px;"><strong>调控轴心：</strong> 细胞周期蛋白依赖性激酶（[[CDKs]]）与周期蛋白（[[Cyclins]]）的复合物是驱动周期的引擎，而 [[p53]]、p21 等抑癌蛋白则负责在 DNA 受损时制动周期。</li><br />
</ul><br />
<br />
<br />
[Image of the cell cycle checkpoints]<br />
<br />
<br />
<h2 style="background: linear-gradient(to right, #1e3a8a, #ffffff); color: #ffffff; padding: 8px 15px; border-radius: 4px; font-size: 1.2em; margin-top: 35px; text-decoration: none !important;">临床病理与细胞工程中的增殖</h2><br />
<br />
<h3 style="color: #1e40af; border-bottom: 2px solid #dbeafe; display: inline-block; padding-bottom: 3px; margin-top: 20px;">1. 肿瘤增殖异质性</h3><br />
<p style="margin: 10px 0;"><br />
恶性肿瘤通过[[信号通路]]（如 MAPK、PI3K/Akt）的持续激活避开生长抑制。临床常用 **[[Ki-67]] 指数** 评估病理切片中增殖活跃细胞的比例，作为判断肿瘤侵袭性及预后的重要依据。<br />
</p><br />
<br />
<h3 style="color: #1e40af; border-bottom: 2px solid #dbeafe; display: inline-block; padding-bottom: 3px; margin-top: 20px;">2. 过继性细胞治疗中的体外扩增</h3><br />
<p style="margin: 10px 0;"><br />
在 [[CAR-T]] 或 [[TCR-T]] 的生产流程中，需要在 7-14 天内将有限的 T 细胞前体快速增殖至 $10^8 \sim 10^9$ 数量级。维持增殖速率的同时防止细胞[[竭耗]]（Exhaustion）是制备工艺的关键挑战。<br />
</p><br />
<br />
<div style="overflow-x: auto; margin: 30px auto; max-width: 85%;"><br />
<table style="width: 100%; border-collapse: collapse; border: 1px solid #e2e8f0; font-size: 0.9em; text-align: left;"><br />
<tr style="background-color: #f8fafc; border-bottom: 2px solid #1e3a8a;"><br />
<th style="padding: 12px; border: 1px solid #e2e8f0; color: #1e3a8a;">增殖类型</th><br />
<th style="padding: 12px; border: 1px solid #e2e8f0; color: #1e3a8a;">调控特征</th><br />
<th style="padding: 12px; border: 1px solid #e2e8f0; color: #1e3a8a;">代表性场景</th><br />
</tr><br />
<tr><br />
<td style="padding: 10px; border: 1px solid #e2e8f0; background: #fcfdfe; font-weight: bold;">生理性增殖</td><br />
<td style="padding: 10px; border: 1px solid #e2e8f0;">受生长因子严格限制，存在接触抑制。</td><br />
<td style="padding: 10px; border: 1px solid #e2e8f0;">造血干细胞补充、伤口愈合。</td><br />
</tr><br />
<tr><br />
<td style="padding: 10px; border: 1px solid #e2e8f0; background: #fcfdfe; font-weight: bold;">病理性增殖</td><br />
<td style="padding: 10px; border: 1px solid #e2e8f0;">逃避凋亡信号，自分泌生长因子。</td><br />
<td style="padding: 10px; border: 1px solid #e2e8f0;">实体瘤生长、白血病发生。</td><br />
</tr><br />
<tr><br />
<td style="padding: 10px; border: 1px solid #e2e8f0; background: #fcfdfe; font-weight: bold;">工程化增殖</td><br />
<td style="padding: 10px; border: 1px solid #e2e8f0;">利用共刺激信号（CD28/4-1BB）强化。</td><br />
<td style="padding: 10px; border: 1px solid #e2e8f0;">CAR-T 体外大规模扩增。</td><br />
</tr><br />
</table><br />
</div><br />
<br />
<h2 style="background: linear-gradient(to right, #1e3a8a, #ffffff); color: #ffffff; padding: 8px 15px; border-radius: 4px; font-size: 1.2em; margin-top: 35px; text-decoration: none !important;">增殖干预与靶向策略</h2><br />
<ul style="padding-left: 20px; color: #475569;"><br />
<li style="margin-bottom: 10px;"><strong>化疗药物：</strong> 针对 $S$ 期（如抗代谢药）或 $M$ 期（如紫杉醇）阻断细胞分裂。</li><br />
<li style="margin-bottom: 10px;"><strong>靶向抑制剂：</strong> [[CDK4/6 抑制剂]]（如阿贝西利）通过阻断 $G_1/S$ 期转换，在乳腺癌治疗中具有显著疗效。</li><br />
<li style="margin-bottom: 10px;"><strong>重编程技术：</strong> 利用转录因子（如 [[Oct4]], [[Myc]]）重新激活体细胞的增殖潜力，用于诱导多能干细胞的制备。</li><br />
</ul><br />
<br />
<div style="font-size: 0.85em; line-height: 1.8; color: #94a3b8; margin-top: 40px; border-top: 2px solid #f1f5f9; padding-top: 15px;"><br />
<p style="margin-bottom: 8px;"><br />
[1] Hartwell LH, et al. "Cell cycle control and cancer." <em>Science</em>. 2004. <br />
<span style="color: #64748b;">(点评：诺贝尔奖得主撰写的综述，系统定义了细胞周期检查点缺失与恶性转化的直接关联。)</span><br />
</p><br />
<p style="margin-bottom: 8px;"><br />
[2] Nurse P, et al. "Cyclin dependent kinases and cell cycle control." <em>Nature Reviews Molecular Cell Biology</em>. 2011. <br />
<span style="color: #64748b;">(点评：详述了 CDK 家族在不同时相切换中的催化逻辑，是细胞动力学研究的必读文献。)</span><br />
</p><br />
<p style="margin-bottom: 8px;"><br />
[3] June CH, et al. "Ex vivo expansion of T cells for cancer therapy." <em>Cancer Discovery</em>. 2018. <br />
<span style="color: #64748b;">(点评：重点探讨了临床级别 T 细胞增殖的代谢需求及共刺激信号对扩增质量的影响。)</span><br />
</p><br />
</div><br />
<br />
<div style="margin: 40px 0; border: 1px solid #1e3a8a; border-radius: 8px; overflow: hidden; font-size: 0.9em;"><br />
<div style="background-color: #1e3a8a; color: #ffffff; text-align: center; font-weight: bold; padding: 12px; text-decoration: none !important;">细胞增殖 关联导航</div><br />
<div style="padding: 15px; background: #ffffff; line-height: 2; text-align: center;"><br />
[[细胞周期]] • [[DNA 复制]] • [[CDK4/6 抑制剂]] • [[Ki-67 指数]] • [[体外细胞扩增]]<br />
</div><br />
</div><br />
<br />
</div></div>
223.160.136.32