Admin：模板:PBB/2064

2015-09-15T23:13:17Z

模板:PBB/2064

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{{GNF_Protein_box
| Name = V-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)
| image = Trastuzumab Fab-HER2 complex 1N8Z.png
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1n8z.
| PDB = {{PDB2|1MFG}}, {{PDB2|1MFL}}, {{PDB2|1MW4}}, {{PDB2|1N8Z}}, {{PDB2|1QR1}}, {{PDB2|1S78}}, {{PDB2|2A91}}, {{PDB2|2JWA}}, {{PDB2|2KS1}}, {{PDB2|2L4K}}, {{PDB2|3BE1}}, {{PDB2|3H3B}}, {{PDB2|3MZW}}, {{PDB2|3N85}}, {{PDB2|3PP0}}, {{PDB2|3RCD}}
| HGNCid = 3430
| MGIid = 95410
| Symbol = ERBB2
| AltSymbols =; CD340; HER-2; HER-2/neu; HER2; MLN 19; NEU; NGL; TKR1
| IUPHAR =
| ChEMBL = 1824
| OMIM = 164870
| ECnumber = 2.7.10.1
| Homologene = 3273
| GeneAtlas_image1 = PBB_GE_ERBB2_216836_s_at.png
| GeneAtlas_image2 = PBB_GE_ERBB2_210930_s_at.png

| GeneAtlas_image3 =
| Protein_domain_image =
| Function = {{GNF_GO|id=GO:0001042 |text = RNA polymerase I core binding}} {{GNF_GO|id=GO:0004713 |text = protein tyrosine kinase activity}} {{GNF_GO|id=GO:0004714 |text = transmembrane receptor protein tyrosine kinase activity}} {{GNF_GO|id=GO:0004716 |text = receptor signaling protein tyrosine kinase activity}} {{GNF_GO|id=GO:0004888 |text = transmembrane signaling receptor activity}} {{GNF_GO|id=GO:0005006 |text = epidermal growth factor-activated receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0019838 |text = growth factor binding}} {{GNF_GO|id=GO:0019903 |text = protein phosphatase binding}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}} {{GNF_GO|id=GO:0043125 |text = ErbB-3 class receptor binding}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}} {{GNF_GO|id=GO:0046983 |text = protein dimerization activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0010008 |text = endosome membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0016323 |text = basolateral plasma membrane}} {{GNF_GO|id=GO:0016324 |text = apical plasma membrane}} {{GNF_GO|id=GO:0043235 |text = receptor complex}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0001934 |text = positive regulation of protein phosphorylation}} {{GNF_GO|id=GO:0006351 |text = transcription, DNA-dependent}} {{GNF_GO|id=GO:0006468 |text = protein phosphorylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor signaling pathway}} {{GNF_GO|id=GO:0007167 |text = enzyme linked receptor protein signaling pathway}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0007173 |text = epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0007422 |text = peripheral nervous system development}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0007528 |text = neuromuscular junction development}} {{GNF_GO|id=GO:0008045 |text = motor neuron axon guidance}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}} {{GNF_GO|id=GO:0008543 |text = fibroblast growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0014065 |text = phosphatidylinositol 3-kinase cascade}} {{GNF_GO|id=GO:0023014 |text = signal transduction by phosphorylation}} {{GNF_GO|id=GO:0030307 |text = positive regulation of cell growth}} {{GNF_GO|id=GO:0030879 |text = mammary gland development}} {{GNF_GO|id=GO:0032321 |text = positive regulation of Rho GTPase activity}} {{GNF_GO|id=GO:0032886 |text = regulation of microtubule-based process}} {{GNF_GO|id=GO:0033088 |text = negative regulation of immature T cell proliferation in thymus}} {{GNF_GO|id=GO:0042060 |text = wound healing}} {{GNF_GO|id=GO:0042552 |text = myelination}} {{GNF_GO|id=GO:0043406 |text = positive regulation of MAP kinase activity}} {{GNF_GO|id=GO:0045087 |text = innate immune response}} {{GNF_GO|id=GO:0045727 |text = positive regulation of translation}} {{GNF_GO|id=GO:0045765 |text = regulation of angiogenesis}} {{GNF_GO|id=GO:0045785 |text = positive regulation of cell adhesion}} {{GNF_GO|id=GO:0045943 |text = positive regulation of transcription from RNA polymerase I promoter}} {{GNF_GO|id=GO:0045945 |text = positive regulation of transcription from RNA polymerase III promoter}} {{GNF_GO|id=GO:0046777 |text = protein autophosphorylation}} {{GNF_GO|id=GO:0048011 |text = neurotrophin TRK receptor signaling pathway}} {{GNF_GO|id=GO:0048015 |text = phosphatidylinositol-mediated signaling}} {{GNF_GO|id=GO:0050679 |text = positive regulation of epithelial cell proliferation}} {{GNF_GO|id=GO:0070372 |text = regulation of ERK1 and ERK2 cascade}}
| Hs_EntrezGene = 2064
| Hs_Ensembl = ENSG00000141736
| Hs_RefseqmRNA = NM_001005862
| Hs_RefseqProtein = NP_001005862
| Hs_GenLoc_db = hg19
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 37844167
| Hs_GenLoc_end = 37886679
| Hs_Uniprot = P04626
| Mm_EntrezGene = 13866
| Mm_Ensembl = ENSMUSG00000062312
| Mm_RefseqmRNA = NM_001003817
| Mm_RefseqProtein = NP_001003817
| Mm_GenLoc_db = mm9
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 98412470
| Mm_GenLoc_end = 98437716
| Mm_Uniprot = P70424
| path = PBB/2064
}}

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