https://www.yiliao.com/index.php?action=history&feed=atom&title=%E6%8B%93%E6%89%91%E6%9B%BF%E5%BA%B7 2026-04-18T04:40:57Z 本wiki的该页面的版本历史 MediaWiki 1.35.1 https://www.yiliao.com/index.php?title=%E6%8B%93%E6%89%91%E6%9B%BF%E5%BA%B7&diff=304123&oldid=prev 2021-07-21T16:47:33Z

<p>建立内容为“{{noteTA |T=zh-hant:托普乐肯; zh-hans:拓扑替康; |1=zh-hant:托普乐肯; zh-hans:拓扑替康; }} {{drugbox | IUPAC_name = (&#039;&#039;S&#039;&#039;)-10-[(dimethylamino)me…”的新页面</p> <p><b>新页面</b></p><div>{{noteTA<br /> |T=zh-hant:托普乐肯; zh-hans:拓扑替康;<br /> |1=zh-hant:托普乐肯; zh-hans:拓扑替康;<br /> }}<br /> <br /> {{drugbox <br /> | IUPAC_name = (''S'')-10-[(dimethylamino)methyl]-4-ethyl-4,9-&lt;br&gt;dihydroxy-1''H''-pyrano[3',4':6,7]indolizino[1,2-b]&lt;br&gt;quinoline-3,14(4''H'',12''H'')-dione<br /> | image = Topotecan Structural Formula V.1.svg<br /> | CAS_number = 123948-87-8 <br /> | ATC_prefix = L01 <br /> | ATC_suffix = XX17 <br /> | PubChem = 60700 <br /> | DrugBank = APRD00687 <br /> | C = 23 |H = 23 |N = 3 |O = 5<br /> | molecular_weight = 421.446 [[克|g]]/[[摩尔|mol]] <br /> | bioavailability = NA<br /> | protein_bound = 35% <br /> | metabolism = [[肝脏]]<br /> | elimination_half-life = 2-3小时<br /> | excretion = [[肾脏]]<br /> | pregnancy_AU = D<br /> | pregnancy_US = D<br /> | legal_UK = POM<br /> | legal_US = Rx-only<br /> | routes_of_administration = 静脉注射<br /> }}<br /> '''托普乐肯'''（'''Topotecan'''；商品名：'''Hycamtin'''®，'''癌康定'''）是一种[[化学治疗]]药物，为[[拓朴异构酶]]I抑制物，一般用来治疗[[卵巢癌]]与[[肺癌]]等[[癌症]]。<br /> <br /> ==给药方式==<br /> <br /> 为[[静脉注射]]，不过有口服的研究。<br /> <br /> ==[[副作用]]==<br /> *[[腹泻]]<br /> *低[[全血细胞计数|血细胞计数]]<br /> *骨髓抑制<br /> *容易受到[[感染]]<br /> <br /> ==参见==<br /> *[http://www.cancer.gov/Templates/drugdictionary.aspx?CdrID=41185 NCI Drug Dictionary Definition of Topotecan]<br /> *[http://www.cancer.gov/cancertopics/druginfo/topotecanhydrochloride NCI Drug Information for Patients]<br /> <br /> {{化疗药物}}<br /> <br /> [[Category:拓扑异构酶抑制剂]]<br /> <br /> [[Category:吡喃吲嗪喹啉]] [[Category:内酯]] [[Category:内酰胺]]<br /> ==参考来源==<br /> *[http://zh.wikipedia.org/wiki/%E6%89%98%E6%99%AE%E6%A8%82%E8%82%AF 维基百科-托普樂肯]</div>

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