123.130.221.191：建立内容为“{{Infobox protein family | Symbol = Gelsolin | Name = Gelsolin | image = PDB 1pd0 EBI.jpg | width = | caption = crystal structure of the copii coat subunit, sec2…”的新页面

2021-07-21T18:47:12Z

建立内容为“{{Infobox protein family | Symbol = Gelsolin | Name = Gelsolin | image = PDB 1pd0 EBI.jpg | width = | caption = crystal structure of the copii coat subunit, sec2…”的新页面

新页面

{{Infobox protein family
| Symbol = Gelsolin
| Name = Gelsolin
| image = PDB 1pd0 EBI.jpg
| width =
| caption = crystal structure of the copii coat subunit, sec24, complexed with a peptide from the snare protein sed5 (yeast syntaxin-5)
| Pfam = PF00626
| Pfam_clan = CL0092
| InterPro = IPR007123
| SMART =
| PROSITE =
| MEROPS =
| SCOP = 1vil
| TCDB =
| OPM family =
| OPM protein =
| CAZy =
| CDD =
}}

{{PBB|geneid=2934}}
'''凝溶胶蛋白'''（{{lang-en|Gelsolin}}）是一种[[肌动蛋白]][[结合蛋白]]，是[[肌动蛋白丝]]装配和解聚调节的关键。凝溶胶蛋白是肌动蛋白结合蛋白中凝溶胶蛋白/{{le|绒毛蛋白|villin}}[[超家族]]的重要成员<ref name="Sun">{{cite journal | author = Sun HQ, Yamamoto M, Mejillano M, Yin HL | title = Gelsolin, a multifunctional actin regulatory protein | journal = J. Biol. Chem. | volume = 274 | issue = 47 | pages = 33179–82 |date=November 1999 | pmid = 10559185 | doi = 10.1074/jbc.274.47.33179 }}</ref>。凝溶胶蛋白表达于[[细胞]]内（在[[细胞质基质]]和[[线粒体]]）以及细胞外（[[血浆]]）<ref name="Koya">{{cite journal | author = Koya RC, Fujita H, Shimizu S, Ohtsu M, Takimoto M, Tsujimoto Y, Kuzumaki N | title = Gelsolin inhibits apoptosis by blocking mitochondrial membrane potential loss and cytochrome c release | journal = J. Biol. Chem. | volume = 275 | issue = 20 | pages = 15343–9 |date=May 2000 | pmid = 10809769 | doi = 10.1074/jbc.275.20.15343 }}</ref>。

== 结构 ==

凝溶胶蛋白是一个82千道尔顿的[[蛋白质]]，具有六个[[同源]]亚[[结构域]]，称为S1-S6。每个亚结构域都包含有五片β折叠，旁边缀有两个α螺旋，一个垂直，另一个平行于β折叠片。其[[N端]]（S1-S3）和[[C端]]（S4-S6）各自组成了一个额外的β折叠<ref name="Kiselar">{{cite journal | author = Kiselar JG, Janmey PA, Almo SC, Chance MR | title = Visualizing the Ca2+-dependent activation of gelsolin by using synchrotron footprinting | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 100 | issue = 7 | pages = 3942–7 |date=April 2003 | pmid = 12655044 | pmc = 153027 | doi = 10.1073/pnas.0736004100 }}</ref>。

==参考文献==

{{reflist|2}}

==外部链接==
* {{MeshName|Gelsolin}}

==参考来源==
*[http://zh.wikipedia.org/wiki/%E5%87%9D%E6%BA%B6%E8%83%B6%E8%9B%8B%E7%99%BD 维基百科-凝溶胶蛋白]

凝溶胶蛋白 - 版本历史

123.130.221.191：建立内容为“{{Infobox protein family | Symbol = Gelsolin | Name = Gelsolin | image = PDB 1pd0 EBI.jpg | width = | caption = crystal structure of the copii coat subunit, sec2…”的新页面