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乙酰肉碱 - 版本历史
2026-04-18T07:35:01Z
本wiki的该页面的版本历史
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2026年1月3日 (六) 00:45 77921020
2026-01-03T00:45:56Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">←上一版本</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">2026年1月3日 (六) 00:45的版本</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >第1行：</td>
<td colspan="2" class="diff-lineno">第1行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff; max-width: 1200px; margin: auto;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div><div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff; max-width: 1200px; margin: auto;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin-bottom: <del class="diffchange diffchange-inline">30px; border-bottom: 1.2px solid #e2e8f0; padding-bottom: 25px</del>;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin-bottom: <ins class="diffchange diffchange-inline">20px</ins>;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <h1 style="margin: 0 0 20px 0; color: #0f172a; font-size: 1.8em;">乙酰肉碱</h1></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <h1 style="margin: 0 0 20px 0; color: #0f172a; font-size: 1.8em;">乙酰肉碱</h1></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="font-size: 1.1em; margin: 10px 0; color: #334155; text-align: justify;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="font-size: 1.1em; margin: 10px 0; color: #334155; text-align: justify;"></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l8" >第8行：</td>
<td colspan="2" class="diff-lineno">第8行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <div class="medical-infobox mw-collapsible mw-collapsed" style="width: 320px; margin: 0 auto 35px auto; border: 1.2px solid #bae6fd; border-radius: 12px; background-color: #ffffff; box-shadow: 0 8px 20px rgba(0,0,0,0.05); overflow: hidden;"></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <div <ins class="diffchange diffchange-inline">style="background-color: #f8f9fa; border: 1px solid #a2a9b1; display: inline-block; padding: 12px 30px 12px 15px; margin-bottom: 35px; border-radius: 4px; min-width: 200px;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <div style="font-weight: bold; text-align: center; margin-bottom: 8px; color: #0f172a; border-bottom: 1px solid #e2e8f0; padding-bottom: 5px;">目录</div></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <ul style="list-style: none; padding: 0; margin: 0; font-size: 0.9em; line-height: 1.8; color: #1e40af;"></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <li><a href="#infobox" style="text-decoration: none; color: #1e40af;">1. 基本信息 (Infobox)</a></li></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <li><a href="#mech" style="text-decoration: none; color: #1e40af;">2. 核心机制：能量与信号</a></li></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <li><a href="#clinical" style="text-decoration: none; color: #1e40af;">3. 临床应用与区别</a></li></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <li><a href="#ref" style="text-decoration: none; color: #1e40af;">4. 学术参考文献</a></li></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <li><a href="#kg" style="text-decoration: none; color: #1e40af;">5. 知识图谱</a></li></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </ul></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> </div></ins></div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline"> <div id="infobox" </ins>class="medical-infobox mw-collapsible mw-collapsed" style="width: 320px; margin: 0 auto 35px auto; border: 1.2px solid #bae6fd; border-radius: 12px; background-color: #ffffff; box-shadow: 0 8px 20px rgba(0,0,0,0.05); overflow: hidden;"></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="padding: 15px; color: #1e40af; background: linear-gradient(135deg, #e0f2fe 0%, #bae6fd 100%); text-align: center; cursor: pointer;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="padding: 15px; color: #1e40af; background: linear-gradient(135deg, #e0f2fe 0%, #bae6fd 100%); text-align: center; cursor: pointer;"></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l52" >第52行：</td>
<td colspan="2" class="diff-lineno">第63行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">核心机制：能量与信号</h2></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <h2 <ins class="diffchange diffchange-inline">id="mech" </ins>style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">核心机制：能量与信号</h2></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="margin: 15px 0;">ALCAR 的独特之处在于它既是能量代谢的辅助者，又是神经信号的调节者。</p></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <p style="margin: 15px 0;">ALCAR 的独特之处在于它既是能量代谢的辅助者，又是神经信号的调节者。</p></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l94" >第94行：</td>
<td colspan="2" class="diff-lineno">第105行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'>−</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div> <h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">临床应用与区别</h2></div></td><td class='diff-marker'>+</td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div> <h2 <ins class="diffchange diffchange-inline">id="clinical" </ins>style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">临床应用与区别</h2></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin-bottom: 25px; border: 1px solid #e2e8f0; border-radius: 8px; padding: 20px; background-color: #f8fafc;"></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> <div style="margin-bottom: 25px; border: 1px solid #e2e8f0; border-radius: 8px; padding: 20px; background-color: #f8fafc;"></div></td></tr>
<tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l130" >第130行：</td>
<td colspan="2" class="diff-lineno">第141行：</td></tr>
<tr><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td><td class='diff-marker'> </td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div> </div></div></td></tr>
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77921020
https://www.yiliao.com/index.php?title=%E4%B9%99%E9%85%B0%E8%82%89%E7%A2%B1&diff=312429&oldid=prev
77921020：建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面
2026-01-03T00:43:26Z
<p>建立内容为“<div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff…”的新页面</p>
<p><b>新页面</b></p><div><div style="padding: 0 4%; line-height: 1.8; color: #1e293b; font-family: 'Helvetica Neue', Helvetica, 'PingFang SC', Arial, sans-serif; background-color: #ffffff; max-width: 1200px; margin: auto;"><br />
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<h1 style="margin: 0 0 20px 0; color: #0f172a; font-size: 1.8em;">乙酰肉碱</h1><br />
<p style="font-size: 1.1em; margin: 10px 0; color: #334155; text-align: justify;"><br />
<strong>乙酰肉碱</strong>（Acetyl-L-Carnitine, 简称 <strong>ALCAR</strong>）是 L-肉碱的一种乙酰化酯形式，也是生物体内天然存在的代谢物。与普通的 L-肉碱主要作用于肌肉不同，ALCAR 具有独特的<strong>亲脂性</strong>，能够轻易穿过<strong>[[血脑屏障]]</strong>，直接作用于中枢神经系统。它在体内主要扮演双重角色：一是作为<strong>[[线粒体]]</strong>的“燃料搬运工”，协助脂肪酸代谢产生能量；二是作为<strong>[[乙酰基]]</strong>的供体，参与合成关键的神经递质<strong>[[乙酰胆碱]]</strong>。因此，ALCAR 被广泛用于改善认知功能（如老年痴呆）、缓解<strong>[[神经病理性疼痛]]</strong>以及作为抗衰老的膳食补充剂。<br />
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<div style="font-size: 1.2em; font-weight: bold; letter-spacing: 1.2px;">乙酰肉碱</div><br />
<div style="font-size: 0.7em; opacity: 0.85; margin-top: 4px; white-space: nowrap;">Acetyl-L-Carnitine (点击展开)</div><br />
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<div style="font-size: 0.8em; color: #64748b; margin-top: 12px; font-weight: 600;">能穿透BBB的肉碱形式</div><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; width: 40%; white-space: nowrap;">化学式</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">C<sub>9</sub>H<sub>17</sub>NO<sub>4</sub></td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; white-space: nowrap;">分类</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #1e40af;">[[促智药]], 氨基酸衍生物</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; white-space: nowrap;">主要靶点</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">[[线粒体]], [[胆碱能系统]]</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; white-space: nowrap;">生物利用度</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #15803d;">高 (优于普通肉碱)</td><br />
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<th style="text-align: left; padding: 6px 12px; background-color: #f1f5f9; color: #475569; border-bottom: 1px solid #e2e8f0; white-space: nowrap;">半衰期</th><br />
<td style="padding: 6px 12px; border-bottom: 1px solid #e2e8f0; color: #0f172a;">约 4.2 小时</td><br />
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<td style="padding: 6px 12px; color: #1e40af;">[[糖尿病神经病变]], [[认知障碍]]</td><br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">核心机制：能量与信号</h2><br />
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<p style="margin: 15px 0;">ALCAR 的独特之处在于它既是能量代谢的辅助者，又是神经信号的调节者。</p><br />
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<th style="padding: 12px; border: 1px solid #cbd5e1; width: 20%; color: #0f172a;">功能维度</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; width: 45%; color: #1e40af;">具体生化过程</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; color: #475569;">生理意义</th><br />
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<td style="padding: 12px; border: 1px solid #cbd5e1; font-weight: bold;">1. 线粒体供能</td><br />
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将长链脂肪酸运输入线粒体基质进行 <strong>[[β-氧化]]</strong>。同时，乙酰基部分可直接进入三羧酸循环 (TCA) 生成 ATP。<br />
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<td style="padding: 12px; border: 1px solid #cbd5e1;"><br />
为高能耗的<strong>脑细胞</strong>和心肌细胞提供燃料，对抗疲劳和线粒体衰退。<br />
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<td style="padding: 12px; border: 1px solid #cbd5e1; font-weight: bold;">2. 神经递质合成</td><br />
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通过捐赠乙酰基，与辅酶A结合生成乙酰辅酶A，进而促进 <strong>[[乙酰胆碱]]</strong> (Acetylcholine) 的生物合成。<br />
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<td style="padding: 12px; border: 1px solid #cbd5e1;"><br />
增强突触可塑性，改善<strong>记忆力</strong>、注意力和学习能力（类似痴呆药物机制）。<br />
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<td style="padding: 12px; border: 1px solid #cbd5e1; font-weight: bold;">3. 表观遗传调节</td><br />
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提供乙酰基用于组蛋白乙酰化 (Histone Acetylation)，特别是调节 mGlu2 受体基因的表达 (NF-κB途径)。<br />
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这是其具有<strong>快速抗抑郁</strong>效果的潜在机制，能逆转压力导致的突触缺陷。<br />
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<h2 style="background: #f1f5f9; color: #0f172a; padding: 10px 18px; border-radius: 0 6px 6px 0; font-size: 1.25em; margin-top: 40px; border-left: 6px solid #0f172a; font-weight: bold;">临床应用与区别</h2><br />
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<h3 style="margin-top: 0; color: #b91c1c; font-size: 1.1em; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;">神经病理性疼痛</h3><br />
<p style="text-align: justify; color: #334155; font-size: 0.95em;"><br />
ALCAR 在治疗<strong>[[糖尿病周围神经病变]]</strong> (DPN) 方面有大量临床证据。它不仅能显著减轻疼痛，还能促进神经再生（增加神经生长因子 NGF 的受体表达）。对于化疗药物（如紫杉醇）诱导的神经毒性也有保护作用。<br />
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<p style="margin: 15px 0;"><strong>ALCAR 与 L-肉碱的区别：</strong></p><br />
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<th style="padding: 12px; border: 1px solid #cbd5e1; width: 25%;">特性</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; width: 37%;">L-肉碱 (L-Carnitine)</th><br />
<th style="padding: 12px; border: 1px solid #cbd5e1; width: 37%; color: #b91c1c;">乙酰肉碱 (ALCAR)</th><br />
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<td style="padding: 12px; border: 1px solid #cbd5e1; font-weight: bold;">穿透血脑屏障</td><br />
<td style="padding: 12px; border: 1px solid #cbd5e1;">困难 (主要在周身)</td><br />
<td style="padding: 12px; border: 1px solid #cbd5e1;"><strong>容易</strong> (主要在脑部)</td><br />
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<td style="padding: 12px; border: 1px solid #cbd5e1; font-weight: bold;">主要用途</td><br />
<td style="padding: 12px; border: 1px solid #cbd5e1;">燃烧脂肪、运动表现、心脏健康</td><br />
<td style="padding: 12px; border: 1px solid #cbd5e1;"><strong>脑力提升</strong>、神经保护、抗抑郁</td><br />
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<td style="padding: 12px; border: 1px solid #cbd5e1; font-weight: bold;">生物利用度</td><br />
<td style="padding: 12px; border: 1px solid #cbd5e1;">较低 (约 15-18%)</td><br />
<td style="padding: 12px; border: 1px solid #cbd5e1;">较高 (吸收更好)</td><br />
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<div style="font-size: 0.92em; line-height: 1.6; color: #1e293b; margin-top: 50px; border-top: 2px solid #0f172a; padding: 15px 25px; background-color: #f8fafc; border-radius: 0 0 10px 10px;"><br />
<span style="color: #0f172a; font-weight: bold; font-size: 1.05em; display: inline-block; margin-bottom: 15px;">学术参考文献与权威点评</span><br />
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<p style="margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;"><br />
[1] <strong>Ames BN, Liu J. (2004).</strong> <em>Delaying the mitochondrial decay of aging with acetylcarnitine.</em> <strong>[[Annals of the New York Academy of Sciences]]</strong>. 2004;1033:108-116.<br><br />
<span style="color: #475569;">[学术点评]：抗衰老经典。Bruce Ames 证明 ALCAR 结合硫辛酸能逆转老年大鼠的线粒体功能衰退，改善记忆力。</span><br />
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<p style="margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;"><br />
[2] <strong>Nasca C, et al. (2013).</strong> <em>Acetyl-L-carnitine deficiency in patients with major depressive disorder.</em> <strong>[[PNAS]]</strong>. 2018;115(34):8627-8632.<br><br />
<span style="color: #475569;">[学术点评]：抑郁症突破。发现抑郁症患者体内 ALCAR 水平显著降低，且补充 ALCAR 可通过表观遗传机制发挥快速抗抑郁作用。</span><br />
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<p style="margin: 12px 0; border-bottom: 1px solid #e2e8f0; padding-bottom: 10px;"><br />
[3] <strong>Sima AA, et al. (2005).</strong> <em>Acetyl-L-carnitine improves pain, nerve regeneration, and vibratory perception in patients with chronic diabetic neuropathy.</em> <strong>[[Diabetes Care]]</strong>. 2005;28(1):89-94.<br><br />
<span style="color: #475569;">[学术点评]：临床实证。大规模双盲试验证实了 ALCAR 对糖尿病神经病变的止痛和神经修复效果。</span><br />
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乙酰肉碱 (ALCAR) · 知识图谱<br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">前体/原料</td><br />
<td style="padding: 10px 15px; color: #334155;">[[赖氨酸]] • [[甲硫氨酸]] • [[乙酰辅酶A]]</td><br />
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<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">协同成分</td><br />
<td style="padding: 10px 15px; color: #334155;">[[硫辛酸]] (ALA) • [[辅酶Q10]] • [[肌酸]]</td><br />
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<tr style="border-bottom: 1px solid #f1f5f9;"><br />
<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">代谢产物</td><br />
<td style="padding: 10px 15px; color: #334155;">[[乙酰胆碱]] • [[ATP]] • [[L-肉碱]]</td><br />
</tr><br />
<tr><br />
<td style="width: 85px; background-color: #f8fafc; color: #334155; font-weight: 600; padding: 10px 12px; text-align: right; vertical-align: middle; white-space: nowrap;">相关疾病</td><br />
<td style="padding: 10px 15px; color: #334155;">[[阿尔茨海默病]] • [[糖尿病神经病变]] • [[抑郁症]]</td><br />
</tr><br />
</table><br />
</div><br />
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